Cursó la licenciatura en Química Farmacéutica Biológica en la Universidad Autónoma Metropolitana, Unidad Xochimilco; obtuvo el grado de Maestría en Biomedicina Molecular en el Instituto Politécnico Nacional y el Doctorado en Ciencias Biomédicas de la Facultad de Medicina en la Universidad Nacional Autónoma de México, así como el posdoctorado en el Departamento de Genética, Microbiología y Estadística de la Facultad de Biología en la Universidad de Barcelona. Actualmente es Investigador en Ciencias Médicas “D”, adscrito al laboratorio de Genómica del Metabolismo Óseo del INMEGEN y miembro del Sistema Nacional de Investigadores (SNI) Nivel II.
En 2005 inició o colabora en las líneas de investigación: Genómica de las enfermedades autoinmunes, Genómica de Enfermedades Hepáticas, Genómica de enfermedades metabólicas, Genómica del metabolismo Óseo, Genómica del Microbioma y Proteómica, englobando proyectos dirigidos a la búsqueda de biomarcadores y marcadores de riesgo genético, entre otros temas. Estas líneas han tenido contribuciones importantes, tales como la identificación de microRNAs como potenciales biomarcadores y como herramienta de apoyo en el diagnóstico del Osteosarcoma y de la Osteoporosis; aunado a que su grupo de investigación es pionero en la identificación de los factores genéticos de la osteoporosis en la población mexicana.
Ha publicado 37 artículos de investigación en revistas internacionales y nacionales y 1 capítulo de libro. Muchos de los resultados de las líneas mencionados se han publicado en revistas del más alto impacto, tales como Journal Bone Mineral Research, Annals of Rheumatic Diseases y PLoS One, y cuenta con cerca de 750 citas. Ha dirigido 12 de tesis, que incluyen 1 de doctorado, 8 de maestría y 3 de licenciatura. Desde 2005 es profesor del Posgrado de Ciencias Biomédicas y del Posgrado en Ciencias Biológicas de la UNAM. Ha recibido 5 premios y distinciones. Destaca su participación como Miembro de la red temática de Envejecimiento, Salud y Desarrollo Social.

Artículos

• Aparicio-Bautista DI, Becerra-Cervera A, Rivera-Paredez B, Aguilar-Ordonez I, Rios-Castro E, Reyes-Grajeda JP, Salmeron J, Hidalgo-Bravo A, Velazquez-Cruz R. Label-free quantitative proteomics in serum reveals candidate biomarkers associated with low bone mineral density in Mexican postmenopausal women. Geroscience. 2024 Apr; 46(2):2177-2195.

• Argoty-Pantoja AD, Velazquez-Cruz R, Salmeron J, Rivera-Paredez B. An approach for searching genes in signaling pathways or gene-gene interaction networks related to Hypertension in the Mexican population. Gene. 2024 Feb 5; 894:147973.

• Argoty-Pantoja AD, Velazquez-Cruz R, Meneses-Leon J, Salmeron J, Rivera-Paredez B. Triglyceride-glucose index is associated with hypertension incidence up to 13 years of follow-up in mexican adults. Lipids Health Dis. 2023 Sep 27; 22(1):162.

• Cabrera-Aldana EE, Balderas-Martinez YI, Velazquez-Cruz R, Tovar-Y-Romo LB, Sevilla-Montoya R, Martinez-Cruz A, Martinez-Cordero C, Valdes-Flores M, Santamaria-Olmedo M, Hidalgo-Bravo A, Guizar-Sahagun G. Administration of Tamoxifen Can Regulate Changes in Gene Expression during the Acute Phase of Traumatic Spinal Cord Injury. Curr Issues Mol Biol. 2023 Sep 13; 45(9):7476-7491.

• Leon-Reyes G, Argoty-Pantoja AD, Becerra-Cervera A, Lopez-Montoya P, Rivera-Paredez B, Velazquez-Cruz R. Oxidative-Stress-Related Genes in Osteoporosis: A Systematic Review. Antioxidants (Basel). 2023 Apr 12; 12(4):None.

• Rosalba Sevilla-Montoya, Addy C. C. Helguera-Reppeto, Irma E. E. Monroy-Munoz, Tania A. A. Vargas-Pavia, Elias I. Valdes-Montoya, Mario Solis-Paredes, Johnatan Torres-Torres, Rafael Velazquez-Cruz, Jose Esteban Munoz-Medina, Claudia Martinez-Cordero, Alberto Hidalgo-Bravo. Blood Type Associated with the Risk of COVID-19 Infection in Pregnant Women. Am J Med Genet. 2023 apr; 13(7):.

• Robles-Rivera K, Rivera-Paredez B, Quezada-Sanchez AD, Velazquez-Cruz R, Salmeron J. Advanced glycation end products are associated with cardiovascular risk in the Mexican population. Nutr Metab Cardiovasc Dis. 2023 Apr; 33(4):826-834.

• Leon-Reyes G, Argoty-Pantoja AD, Rivera-Paredez B, Hidalgo-Bravo A, Flores YN, Salmeron J, Velazquez-Cruz R. Interaction between SIDT2 and ABCA1 Variants with Nutrients on HDL-c Levels in Mexican Adults. Nutrients. 2023 Jan 11; 15(2):None.

• Salazar-Valencia IG, Villamil-Ramirez H, Barajas-Olmos F, Guevara-Cruz M, Macias-Kauffer LR, Garcia-Ortiz H, Hernandez-Vergara O, De Sandy-Galan DAD, Leon-Mimila P, Centeno-Cruz F, Gonzalez-Salazar LE, Guizar-Heredia R, Pichardo-Ontiveros E, Jacobo-Albavera L, Posadas-Sanchez R, Vargas-Alarcon G, Velazquez-Cruz R, Gutierrez-Aguilar R, Zerrweck C, Rocha-Gonzalez HI, Reyes-Garcia JG, Carrasco-Portugal MD, Flores-Murrieta FJ, Tovar AR, Orozco L, Villarreal-Molina T, Canizales-Quinteros S. Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions. Genes (Basel). 2022 DEC; 13(12):None.

• PerezGrovas-Saltijeral A, Ochoa-Morales A, Jara-Prado A, Velazquez-Cruz R, Rivera-Paredez B, Davila-OrtizdeMontellano D, Benitez-Alonso EO, Santamaria-Olmedo M, Sevilla-Montoya R, Marfil-Marin E, Valdes-Flores M, Martinez-Ruano L, Camacho-Molina A, Hidalgo-Bravo A. Unraveling the role of relative telomere length and CAG expansion on initial symptoms of Juvenile Huntington Disease. Eur J Neurol. 2022 Nov 24; :.

• Rivera-Paredez B, Aparicio-Bautista DI, Argoty-Pantoja AD, Patino N, Flores Morales J, Salmeron J, Leon-Reyes G, Velazquez-Cruz R. Association of MARC1, ADCY5, and BCO1 Variants with the Lipid Profile, Suggests an Additive Effect for Hypertriglyceridemia in Mexican Adult Men. Int J Mol Sci. 2022 Oct 5; 23(19):.

• Robles-Rivera K, Argoty-Pantoja AD, Hidalgo-Bravo A, Quezada-Sanchez AD, Leon-Reyes G, Flores YN, Salmeron J, Velazquez-Cruz R, Rivera-Paredez B. Uric Acid Levels Are Associated with Bone Mineral Density in Mexican Populations: A Longitudinal Study. Nutrients. 2022 OCT; 14(20):None.

• Solis-Vivanco A, Santamaria-Olmedo M, Rodriguez-Juarez D, Valdes-Flores M, Gonzalez-Castor C, Velazquez-Cruz R, Ramirez-Salazar E, Garcia-Ulloa AC, Hidalgo-Bravo A. miR-145, miR-92a and miR-375 Show Differential Expression in Serum from Patients with Diabetic Retinopathies. Am J Med Genet. 2022 OCT; 12(10):None.

• Romero Y, Balderas-Martinez YI, Vargas-Morales MA, Castillejos-Lopez M, Vazquez-Perez JA, Calyeca J, Torres-Espindola LM, Patino N, Camarena A, Carlos-Reyes A, Flores-Soto E, Leon-Reyes G, Sierra-Vargas MP, Herrera I, Luis-Garcia ER, Ruiz V, Velazquez-Cruz R, Aquino-Galvez A. Effect of Hypoxia in the Transcriptomic Profile of Lung Fibroblasts from Idiopathic Pulmonary Fibrosis. Cells. 2022 OCT; 11(19):None.

• Torres-Soria AK, Romero Y, Balderas-Martinez YI, Velazquez-Cruz R, Torres-Espindola LM, Camarena A, Flores-Soto E, Solis-Chagoyan H, Ruiz V, Carlos-Reyes A, Salinas-Lara C, Luis-Garcia ER, Chavez J, Castillejos-Lopez M, Aquino-Galvez A. Functional Repercussions of Hypoxia-Inducible Factor-2 alpha in Idiopathic Pulmonary Fibrosis. Cells. 2022 OCT; 11(19):None.

• Hidalgo-Bravo A, Rivera-Paredez B, Leon-Reyes G, Patino N, Castillejos-Lopez M, Salmeron J, Velazquez-Cruz R. Unravelling the Contribution of the rs7041 and rs4588 Polymorphisms of the GC Gene and Serum VDBP Levels for Developing Metabolic Syndrome in the Mexican Population. Int J Mol Sci. 2022 Sep 13; 23(18):.

• Castillejos-Lopez M, Torres-Espindola LM, Huerta-Cruz JC, Flores-Soto E, Romero-Martinez BS, Velazquez-Cruz R, Higuera-Iglesias A, Camarena A, Torres-Soria AK, Salinas-Lara C, Fernandez-Plata R, Alvarado-Vasquez N, Solis-Chagoyan H, Ruiz V, Aquino-Galvez A. Ivermectin: A Controversial Focal Point during the COVID-19 Pandemic. Life (Basel). 2022 Sep 6; 12(9):.

• Palacios-Gonzalez B, Leon-Reyes G, Rivera-Paredez B, Ibarra-Gonzalez I, Vela-Amieva M, Flores YN, Canizales-Quinteros S, Salmeron J, Velazquez-Cruz R. Targeted Metabolomics Revealed a Sex-Dependent Signature for Metabolic Syndrome in the Mexican Population. Nutrients. 2022 Sep 6; 14(18):.

• Lopez-Montoya P, Cerqueda-Garcia D, Rodriguez-Flores M, Lopez-Contreras B, Villamil-Ramirez H, Moran-Ramos S, Molina-Cruz S, Rivera-Paredez B, Antuna-Puente B, Velazquez-Cruz R, Villarreal-Molina T, Canizales-Quinteros S. Association of Gut Microbiota with Atherogenic Dyslipidemia, and Its Impact on Serum Lipid Levels after Bariatric Surgery. Nutrients. 2022 SEP; 14(17):None.

• Fernandez-Plata R, Higuera-Iglesias AL, Torres-Espindola LM, Aquino-Galvez A, Cruz RV, Camarena A, Alderete JC, Garcia JR, Alvarado-Vasquez N, Briseno DM, Castillejos-Lopez M. Risk of Pulmonary Fibrosis and Persistent Symptoms Post-COVID-19 in a Cohort of Outpatient Health Workers. Am J Med Genet. 2022 SEP; 14(9):None.

• Hernandez-Lopez R, Canto-Osorio F, Vidana-Perez D, Torres-Ibarra L, Rivera-Paredez B, Gallegos-Carrillo K, Velazquez R, Ramirez P, Barrientos-Gutierrez T, Salmeron J, Lopez-Olmedo N. Soft drink and non-caloric soft drink intake and their association with blood pressure: the Health Workers Cohort Study. Nutr J. 2022 JUN 7; 21(1):None.

• Rivera-Paredez B, Quezada-Sanchez AD, Robles-Rivera K, Hidalgo-Bravo A, Denova-Gutierrez E, Leon-Reyes G, Flores YN, Salmeron J, Velazquez-Cruz R. Dietary inflammatory index and bone mineral density in Mexican population. Osteoporos Int. 2022 May 28; :.

• Leon-Reyes G, Rivera-Paredez B, Hidalgo-Bravo A, Flores YN, Salmeron J, Velazquez-Cruz R. Common variant rs6564851 near the beta-carotene oxygenase 1 gene is associated with plasma triglycerides levels in middle-aged Mexican men adults. Nutr Res. 2022 Jul; 103:30-39.

• Garcia-Rojas MD, Palma-Cordero G, Martinez-Ramirez CO, Ponce de Leon-Suarez V, Valdes-Flores M, Castro-Hernandez C, Rubio-Lightbourn J, Hernandez-Zamora E, Reyes-Maldonado E, Velazquez-Cruz R, Barredo-Prieto B, Casas-Avila L. Association of Polymorphisms in Estrogen Receptor Genes (ESR1 and ESR2) with Osteoporosis and Fracture-Involvement of Comorbidities and Epistasis. DNA Cell Biol. 2022 Mar 14; :.

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  Ramirez-Salazar EG, Almeraya EV, Lopez-Perez TV, Jimenez-Salas Z, Patino N, Velazquez-Cruz R. MicroRNA-1270 Inhibits Cell Proliferation, Migration, and Invasion via Targeting IRF8 in Osteoblast-like Cell Lines. Curr Issues Mol Biol. 2022 Mar 1; 44(3):1182-1190.

• Garcia-Ortiz H, Barajas-Olmos F, Contreras-Cubas C, Cid-Soto MA, Cordova EJ, Centeno-Cruz F, Mendoza-Caamal E, Ciceron-Arellano I, Flores-Huacuja M, Baca P, Bolnick DA, Snow M, Flores-Martinez SE, Ortiz-Lopez R, Reynolds AW, Blanchet A, Morales-Marin M, Velazquez-Cruz R, Kostic AD, Galaviz-Hernandez C, Garcia-Zapien AG, Jimenez-Lopez JC, Leon-Reyes G, Salas-Bautista EG, Lazalde-Ramos BP, Jimenez-Ruiz JL, Salas-Martinez G, Ramos-Madrigal J, Mirzaeicheshmeh E, Saldana-Alvarez Y, Del Carmen Abrahantes-Perez M, Loeza-Becerra F, Mojica-Espinosa R, Sanchez-Quinto F, Rangel-Villalobos H, Sosa-Macias M, Sanchez-Corona J, Rojas-Martinez A, Martinez-Hernandez A, Orozco L. The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas. Nat Commun. 2021 Oct 12; 12(1):5942.

• Flores YN, Amoon AT, Su B, Velazquez-Cruz R, Ramirez-Palacios P, Salmeron J, Rivera-Paredez B, Sinsheimer JS, Lusis AJ, Huertas-Vazquez A, Saab S, Glenn BA, May FP, Williams KJ, Bastani R, Bensinger SJ. Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico. Lipids Health Dis. 2021 Oct 10; 20(1):136.

• Rivera-Paredez B, Hidalgo-Bravo A, Leon-Reyes G, Leon-Maldonado LS, Aquino-Galvez A, Castillejos-Lopez M, Denova-Gutierrez E, Flores YN, Salmeron J, Velazquez-Cruz R. Total, Bioavailable, and Free 25-Hydroxyvitamin D Equally Associate with Adiposity Markers and Metabolic Traits in Mexican Adults. Nutrients. 2021 Sep 23; 13(10):.

• Guerrero-Contreras I, Hernandez-Tobias EA, Velazquez-Cruz R, Ramirez-Lopez E, Campos-Gongora E, Jimenez-Salas Z. The BDNF rs7934165 polymorphism is a biomarker of central obesity and cardiometabolic risk in Mexican women. Eur Rev Med Pharmacol Sci. 2021 Sep; 25(17):5463-5473.

• Palacios-Gonzalez B, Leon-Reyes G, Rivera-Paredez B, Ibarra-Gonzalez I, Vela-Amieva M, Flores YN, Canizales-Quinteros S, Salmeron J, Velazquez-Cruz R. Serum Metabolite Profile Associated with Sex-Dependent Visceral Adiposity Index and Low Bone Mineral Density in a Mexican Population. Metabolites. 2021 Sep 6; 11(9):.

• Rivera-Paredez B, Hidalgo-Bravo A, Leon-Reyes G, Antuna-Puente B, Flores YN, Salmeron J, Velazquez-Cruz R. Association of GC Variants with Bone Mineral Density and Serum VDBP Concentrations in Mexican Population. Genes (Basel). 2021 Jul 29; 12(8):.

• Hernandez-Lopez R, Hermosillo L, Leon-Maldonado L, Velazquez-Cruz R, Torres-Ibarra L, Lazcano-Ponce E, Lorincz A, Wheeler CM, Bosch FX, Cuzick J, Rivera-Paredez B, Nedjai B, Salmeron J. Performance of an affordable urine self-sampling method for human papillomavirus detection in Mexican women. PLoS One. 2021; 16(7):e0254946.

• Baltazares-Lipp ME, Aguilera-Velasco A, Aquino-Galvez A, Velazquez-Cruz R, Hernandez-Zenteno RJ, Alvarado-Vasquez N, Camarena A, Sierra-Vargas MP, Chavez-Pacheco JL, Ruiz V, Salinas-Lara C, Tena-Suck ML, Romero Y, Torres-Espindola LM, Castillejos-Lopez M. Evaluating of Red Blood Cell Distribution Width, Comorbidities and Electrocardiographic Ratios as Predictors of Prognosis in Patients with Pulmonary Hypertension. Diagnostics (Basel). 2021 Jul 20; 11(7):.

• Rivera-Paredez B, Quezada-Sanchez AD, Denova-Gutierrez E, Torres-Ibarra L, Flores YN, Salmeron J, Velazquez-Cruz R. Diet Modulates the Effects of Genetic Variants on the Vitamin D Metabolic Pathway and Bone Mineral Density in Mexican Postmenopausal Women. J Nutr. 2021 Jul 1; 151(7):1726-1735.

• Denova-Gutierrez E, Rivera-Paredez B, Velazquez-Cruz R, Munoz-Aguirre P, Ramirez-Palacios P, Clark P, Ferretti JL, Salmeron J, Cointry GR. Relationship between physical activity, lean body mass, and bone mass in the Mexican adult population. Arch Osteoporos. 2021 Jun 8; 16(1):94.

• Parra-Torres AY, Enriquez J, Jimenez-Ortega RF, Patino N, Castillejos-Lopez MJ, Torres-Espindola LM, Ramirez-Salazar EG, Velazquez-Cruz R. Expression profiles of the Wnt/beta-catenin signaling-related extracellular antagonists during proliferation and differentiation in human osteoblast-like cells. Exp Ther Med. 2020 Dec; 20(6):254.

• Palacios-Gonzalez B, Ramirez-Salazar EG, Rivera-Paredez B, Quiterio M, Flores YN, Macias-Kauffer L, Moran-Ramos S, Denova-Gutierrez E, Ibarra-Gonzalez I, Vela-Amieva M, Canizales-Quinteros S, Salmeron J, Velazquez-Cruz R. A Multi-Omic Analysis for Low Bone Mineral Density in Postmenopausal Women Suggests a RELATIONSHIP between Diet, Metabolites, and Microbiota. Microorganisms. 2020 Oct 22; 8(11):.

• Leon-Reyes G, Rivera-Paredez B, Lopez JCF, Ramirez-Salazar EG, Aquino-Galvez A, Gallegos-Carrillo K, Denova-Gutierrez E, Salmeron J, Velazquez-Cruz R. The Variant rs1784042 of the SIDT2 Gene is Associated with Metabolic Syndrome through Low HDL-c Levels in a Mexican Population. Genes (Basel). 2020 Oct 14; 11(10):.

• Hidalgo-Bravo A, Hernandez-Medrano C, Sevilla-Montoya R, Rivera-Paredez B, Ramirez-Salazar EG, Flores-Morales J, Patino N, Salmeron J, Valdes-Flores M, Velazquez-Cruz R. Single-nucleotide polymorphism rs10036727 in the SLIT3 gene is associated with osteoporosis at the femoral neck in older Mexican postmenopausal women. Gynecol Endocrinol. 2020 Aug 7; :1-5.

• Meneses-Leon J, Leon-Maldonado L, Macias N, Torres-Ibarra L, Hernandez-Lopez R, Rivera-Paredez B, Flores M, Flores YN, Barrientos-Gutierrez T, Quezada-Sanchez AD, Velazquez-Cruz R, Salmeron J. Sugar-sweetened beverage consumption and risk of hyperuricemia: a longitudinal analysis of the Health Workers Cohort Study participants in Mexico. Am J Clin Nutr. 2020 Jul 9; :.

• Rivera-Paredez B, Torres-Ibarra L, Gonzalez-Morales R, Barrientos-Gutierrez T, Hernandez-Lopez R, Ramirez P, Leon-Maldonado L, Velazquez-Cruz R, Denova-Gutierrez E, Salmeron J. Cumulative soft drink consumption is associated with insulin resistance in Mexican adults. Am J Clin Nutr. 2020 Jun 29; :.

• Monterde-Cruz L, Ramirez-Salazar EG, Rico-Martinez G, Linares-Gonzalez LM, Guzman-Gonzalez R, Delgado-Cedillo E, Estrada-Villasenor E, Valdes-Flores M, Velazquez-Cruz R, Hidalgo-Bravo A. MicroRNA expression in relation with clinical evolution of osteosarcoma. Pathol Res Pract. 2020 Aug; 216(8):153038.

• Ramirez-Salazar EG, Almeraya EV, Lopez-Perez TV, Patino N, Salmeron J, Velazquez-Cruz R. MicroRNA-548-3p overexpression inhibits proliferation, migration, and invasion in osteoblast-like cells by targeting STAT1 and MAFB. J Biochem. 2020 Mar 20; :.

• Moran-Ramos S, Lopez-Contreras BE, Villarruel-Vazquez R, Ocampo-Medina E, Macias-Kauffer L, Martinez-Medina JN, Villamil-Ramirez H, Leon-Mimila P, Del Rio-Navarro BE, Ibarra-Gonzalez I, Vela-Amieva M, Gomez-Perez FJ, Velazquez-Cruz R, Salmeron J, Reyes-Castillo Z, Aguilar-Salinas C, Canizales-Quinteros S. Environmental and intrinsic factors shaping gut microbiota composition and diversity and its relation to metabolic health in children and early adolescents: A population-based study. Gut Microbes. 2020 Jul 3; 11(4):900-917.

• Rivera-Paredez B, Hidalgo-Bravo A, de la Cruz-Montoya A, Martinez-Aguilar MM, Ramirez-Salazar EG, Flores M, Quezada-Sanchez AD, Ramirez-Palacios P, Cid M, Martinez-Hernandez A, Orozco L, Denova-Gutierrez E, Salmeron J, Velazquez-Cruz R. Association between vitamin D deficiency and common variants of Vitamin D binding protein gene among Mexican Mestizo and indigenous postmenopausal women. J Endocrinol Invest. 2020 Jul; 43(7):935-946.

• Romero Y, Castillejos-Lopez M, Romero-Garcia S, Aguayo AS, Herrera I, Garcia-Martin MO, Torres-Espindola LM, Negrete-Garcia MC, Olvera AC, Huerta-Cruz JC, Cruz RV, Cisneros J, Soto EF, Solis-Chagoyan H, Mendoza-Milla C, Cabello-Gutierrez C, Ruiz V, Aquino-Galvez A. Antitumor Therapy under Hypoxic Microenvironment by the Combination of 2-Methoxyestradiol and Sodium Dichloroacetate on Human Non-Small-Cell Lung Cancer. Oxid Med Cell Longev. 2020; 2020:3176375.

• Langley E, Velazquez-Cruz R, Parra-Torres A, Enriquez J. The Non-Aromatic Delta5-Androstenediol Derivative of Dehydroepiandrosterone Acts as an Estrogen Agonist in Neonatal Rat Osteoblasts through an Estrogen Receptor alpha-related Mechanism. Endocr Res. 2019 Dec 24; 1:1-16.

• Denova-Gutierrez E, Clark P, Capozza RF, Nocciolino LM, Ferretti JL, Velazquez-Cruz R, Rivera B, Cointry GR, Salmeron J. Differences in the relation between bone mineral content and lean body mass according to gender and reproductive status by age ranges. J Bone Miner Metab. 2019 Dec 4; 37:.

• Martinez-Aguilar MM, Aparicio-Bautista DI, Ramirez-Salazar EG, Reyes-Grajeda JP, De la Cruz-Montoya AH, Antuna-Puente B, Hidalgo-Bravo A, Rivera-Paredez B, Ramirez-Palacios P, Quiterio M, Valdes-Flores M, Salmeron J, Velazquez-Cruz R. Serum Proteomic Analysis Reveals Vitamin D-Binding Protein (VDBP) as a Potential Biomarker for Low Bone Mineral Density in Mexican Postmenopausal Women. Nutrients. 2019 Nov 21; 11(12):.

• Macias-Kauffer LR, Villamil-Ramirez H, Leon-Mimila P, Jacobo-Albavera L, Posadas-Romero C, Posadas-Sanchez R, Lopez-Contreras BE, Moran-Ramos S, Romero-Hidalgo S, Acuna-Alonzo V, Del-Rio-Navarro BE, Bortolini MC, Gallo C, Bedoya G, Rothhammer F, Gonzalez-Jose R, Ruiz-Linares A, Stephens CR, Velazquez-Cruz R, Fernandez Del Valle-Laisequilla C, Reyes-Garcia JG, Barranco Garduno LM, Carrasco-Portugal MDC, Flores-Murrieta FJ, Vargas-Alarcon G, Aguilar-Salinas CA, Villarreal-Molina T, Canizales-Quinteros S. Genetic contributors to serum uric acid levels in Mexicans and their effect on premature coronary artery disease. Int J Cardiol. 2019 Oct 1; 279:.

• Contreras-Cubas C, Garcia-Ortiz H, Velazquez-Cruz R, Barajas-Olmos F, Baca P, Martinez-Hernandez A, Barbosa-Cobos RE, Ramirez-Bello J, Lopez-Hernandez MA, Svyryd Y, Mutchinick OM, Baca V, Orozco L. Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans. Sci Rep. 2019 Aug 21; 9(1):12165.

• Farias-Cisneros E, Hidalgo-Bravo A, Miranda-Duarte A, Casas-Avila L, Rozental TD, Velazquez-Cruz R, Valdes-Flores M. COL1A1, CCDC170, and ESR1 single nucleotide polymorphisms associated with distal radius fracture in postmenopausal Mexican women. Climacteric. 2020 Feb; 23(1):65-74.

• Aquino-Galvez A, Gonzalez-Avila G, Jimenez-Sanchez LL, Maldonado-Martinez HA, Cisneros J, Toscano-Marquez F, Castillejos-Lopez M, Torres-Espindola LM, Velazquez-Cruz R, Rodriguez VHO, Flores-Soto E, Solis-Chagoyan H, Cabello C, Zuniga J, Romero Y. Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis. Respir Res. 2019 Jun 24; 20(1):130.

• Rivera-Paredez B, Macias-Kauffer L, Fernandez-Lopez JC, Villalobos-Comparan M, Martinez-Aguilar MM, de la Cruz-Montoya A, Ramirez-Salazar EG, Villamil-Ramirez H, Quiterio M, Ramirez-Palacios P, Romero-Hidalgo S, Villarreal-Molina MT, Denova-Gutierrez E, Flores YN, Canizales-Quinteros S, Salmeron J, Velazquez-Cruz R. Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans. Nutrients. 2019 Jun 14; 11(6):.

• Hidalgo-Bravo A, Parra-Torres AY, Casas-Avila L, Jimenez-Ortega RF, Ramirez-Salazar EG, Patino N, Rivera-Paredez B, Salmeron J, Valdes-Flores M, Velazquez-Cruz R. Association of RMND1/CCDC170-ESR1 single nucleotide polymorphisms with hip fracture and osteoporosis in postmenopausal women. Climacteric. 2019 Jan 2; 22:1-8.

• Leon-Mimila P, Villamil-Ramirez H, Lopez-Contreras BE, Moran-Ramos S, Macias-Kauffer LR, Acuna-Alonzo V, Del Rio-Navarro BE, Salmeron J, Velazquez-Cruz R, Villarreal-Molina T, Aguilar-Salinas CA, Canizales-Quinteros S. Low Salivary Amylase Gene (AMY1) Copy Number Is Associated with Obesity and Gut Prevotella Abundance in Mexican Children and Adults. Nutrients. 2018 Nov 1; 10(11):.

• De-La-Cruz-Montoya AH, Ramirez-Salazar EG, Martinez-Aguilar MM, Gonzalez-de-la-Rosa PM, Quiterio M, Abreu-Goodger C, Salmeron J, Velazquez-Cruz R. Identification of miR-708-5p in peripheral blood monocytes: Potential marker for postmenopausal osteoporosis in Mexican-Mestizo population. Exp Biol Med (Maywood). 2018 Oct 15; 243:1535370218806828.

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  Gonzalez-Pena SM, Campos-Gongora E, Avila-Rodriguez HG, Ramirez-Lopez E, Velazquez-Cruz R, Jimenez-Salas Z. JAG1, MEF2C and BDNF polymorphisms associated with bone mineral density in women from Northern Mexico. Biomedica. 2018 Sep 1; 38(3):320-328.

• Ramirez-Salazar EG, Carrillo-Patino S, Hidalgo-Bravo A, Rivera-Paredez B, Quiterio M, Ramirez-Palacios P, Patino N, Valdes-Flores M, Salmeron J, Velazquez-Cruz R. Serum miRNAs miR-140-3p and miR-23b-3p as potential biomarkers for osteoporosis and osteoporotic fracture in postmenopausal Mexican-Mestizo women. Gene. 2018 Dec 30; 679:19-27.

• Rivera-Paredez B, Macias N, Martinez-Aguilar MM, Hidalgo-Bravo A, Flores M, Quezada-Sanchez AD, Denova-Gutierrez E, Cid M, Martinez-Hernandez A, Orozco L, Quiterio M, Flores YN, Salmeron J, Velazquez-Cruz R. Association between Vitamin D Deficiency and Single Nucleotide Polymorphisms in the Vitamin D Receptor and GC Genes and Analysis of Their Distribution in Mexican Postmenopausal Women. Nutrients. 2018 Aug 27; 10(9):.

• Monterde-Cruz L, Ramirez-Salazar EG, Rico-Martinez G, Linares-Gonzalez LM, Guzman-Gonzalez R, Delgado-Cedillo E, Estrada-Villasenor E, Valdes-Flores M, Velazquez-Cruz R, Hidalgo-Bravo A. Circulating miR-215-5p and miR-642a-5p as potential biomarker for diagnosis of osteosarcoma in Mexican population. Hum Cell. 2018 Jun 15; :.

• Larrieta-Carrasco E, Flores YN, Macias-Kauffer LR, Ramirez-Palacios P, Quiterio M, Ramirez-Salazar EG, Leon-Mimila P, Rivera-Paredez B, Cabrera-Alvarez G, Canizales-Quinteros S, Zhang ZF, Lopez-Perez TV, Salmeron J, Velazquez-Cruz R. Genetic variants in COL13A1, ADIPOQ and SAMM50, in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed Mexican population. Exp Mol Pathol. 2018 Feb; 104(1):50-58.

• Grijalva-Pérez A., Esmer C., Romero-Hidalgo S., Rojo-Dominguez A., Rosas-Madrigal S., Velázquez-Cruz R Villarreal-Molina T., Acuña-Alonzo V., Bravo-Oro A., Carnevale A.. Prevalence and ancestral origin of the c.1987delC GAA gene mutation causing Pompe disease in Central Mexico. Am J Med Genet. 2018 2018; 15:None.

• Jimenez-Ortega RF, Ramirez-Salazar EG, Parra-Torres AY, Munoz-Montero SA, Rangel-Escareno C, Salido-Guadarrama I, Rodriguez-Dorantes M, Quiterio M, Salmeron J, Velazquez-Cruz R. Identification of microRNAs in human circulating monocytes of postmenopausal osteoporotic Mexican-Mestizo women: A pilot study. Exp Ther Med. 2017 Dec; 14(6):5464-5472.

• Villalobos-Comparan M, Jimenez-Ortega RF, Estrada K, Parra-Torres AY, Gonzalez-Mercado A, Patino N, Castillejos-Lopez M, Quiterio M, Fernandez-Lopez JC, Ibarra B, Romero-Hidalgo S, Salmeron J, Velazquez-Cruz R. A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1/CCDC170 Locus Is Associated with Bone Mineral Density. Int J Genomics. 2017; 2017:5831020.

• Villalobos-Comparan M, Antuna-Puente B, Villarreal-Molina MT, Canizales-Quinteros S, Velazquez-Cruz R, Leon-Mimila P, Villamil-Ramirez H, Gonzalez-Barrios JA, Merino-Garcia JL, Thompson-Bonilla MR, Jarquin D, Sanchez-Hernandez OE, Rodriguez-Arellano ME, Posadas-Romero C, Vargas-Alarcon G, Campos-Perez F, Quiterio M, Salmeron-Castro J, Carnevale A, Romero-Hidalgo S. Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population. BMC Med Genet. 2017 May 02; 18(1):46.

• Denova-Gutierrez E, Flores YN, Gallegos-Carrillo K, Ramirez-Palacios P, Rivera-Paredez B, Munoz-Aguirre P, Velazquez-Cruz R, Torres-Ibarra L, Meneses-Leon J, Mendez-Hernandez P, Hernandez-Lopez R, Salazar-Martinez E, Talavera JO, Tamayo J, Castanon S, Osuna-Ramirez I, Leon-Maldonado L, Flores M, Macias N, Antunez D, Huitron-Bravo G, Salmeron J. Health workers cohort study: methods and study design. Salud Publica de Mexico. 2016 Nov-Dec; 58(6):708-716.

• Flores YN, Velazquez-Cruz R, Ramirez P, Banuelos M, Zhang ZF, Yee HF Jr, Chang SC, Canizales-Quinteros S, Quiterio M, Cabrera-Alvarez G, Patino N, Salmeron J. Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults. Mol Biol Rep. 2016 Oct 17; :.

• Vargas-Alarcon G, Martinez-Rodriguez N, Velazquez-Cruz R, Perez-Mendez O, Posadas-Sanchez R, Posadas-Romero C, Pena-Duque MA, Martinez-Rios MA, Ramirez-Fuentes S, Fragoso JM. The T>A (rs11646213) gene polymorphism of cadherin-13 (CDH13) gene is associated with decreased risk of developing hypertension in Mexican population. Immunobiology. 2016 Sep 21; :.

• Enriquez J, Velazquez-Cruz R, Parra-Torres A, Gutierrez-Sagal R, Larrea F. The anti-estrogenic activity of indole-3-carbinol in neonatal rat osteoblasts is associated with the estrogen receptor antagonist 2-hydroxyestradiol. J Endocrinol Invest. 2016 Jun 16; :.

• Checa M, Hagood JS, Velazquez-Cruz R, Ruiz V, Garcia-De-Alba C, Rangel-Escareno C, Urrea F, Becerril C, Montano M, Garcia-Trejo S, Cisneros Lira J, Aquino-Galvez A, Pardo A, Selman M. Cigarette Smoke Enhances the Expression of Profibrotic Molecules in Alveolar Epithelial Cells. PLoS One. 2016; 11(3):e0150383.

• Torres LM, Rivera-Espinosa L, Chavez-Pacheco JL, Navas CF, Demetrio JA, Alemon-Medina R, Trujillo F, Perez M, Zapata MM, Cardenas R, Salinas C, Aquino A, Velazquez-Cruz R, Castillejos MD. A New Method to Quantify Ifosfamide Blood Levels Using Dried Blood Spots and UPLC-MS/MS in Paediatric Patients with Embryonic Solid Tumours. PLoS One. 2015; 10(11):e0143421.

• Leon-Mimila P, Vega-Badillo J, Gutierrez-Vidal R, Villamil-Ramirez H, Villareal-Molina T, Larrieta-Carrasco E, Lopez-Contreras BE, Kauffer LR, Maldonado-Pintado DG, Mendez-Sanchez N, Tovar AR, Hernandez-Pando R, Velazquez-Cruz R, Campos-Perez F, Aguilar-Salinas CA, Canizales-Quinteros S. A genetic risk score is associated with hepatic triglyceride content and non-alcoholic steatohepatitis in Mexicans with morbid obesity. Exp Mol Pathol. 2015 Jan 15; 98(2):178-183.

• Velazquez-Cruz R, Jimenez-Ortega RF, Parra-Torres AY, Castillejos-Lopez M, Patino N, Quiterio M, Villarreal-Molina T, Salmeron J. Analysis of association of MEF2C, SOST and JAG1 genes with bone mineral density in Mexican-Mestizo postmenopausal women.. BMC Musculoskelet Disord. 2014 Nov 28; 15:400.

• Larrieta-Carrasco E, Acuna-Alonzo V, Velazquez-Cruz R, Barquera-Lozano R, Leon-Mimila P, Villamil-Ramirez H, Menjivar M, Romero-Hidalgo S, Mendez-Sanchez N, Cardenas V, Banuelos-Moreno M, Flores YN, Quiterio M, Salmeron J, Sanchez-Munoz F, Villarreal-Molina T, Aguilar-Salinas CA, Canizales-Quinteros S. PNPLA3 I148M polymorphism is associated with elevated alanine transaminase levels in Mexican Indigenous and Mestizo populations. Mol Biol Rep. 2014 Apr 2; 41(7):4705-11.

• Velazquez-Cruz R, Garcia-Ortiz H, Castillejos-Lopez M, Quiterio M, Valdes-Flores M, Orozco L, Villarreal-Molina T, Salmeron J. WNT3A gene polymorphisms are associated with bone mineral density variation in postmenopausal mestizo women of an urban Mexican population: findings of a pathway-based high-density single nucleotide screening. Age (Dordr). 2014 Mar 3; 36(3):9635.

• Torres-Espindola LM, Velazquez-Cruz R, Falfan-Valencia R, Chavez-Pacheco JL, Salcedo-Vargas M, Nambo-Lucio MD, Salinas-Lara C, Alemon-Medina R, Granados-Montiel J, Reyes-Servin MA, Granados J, Castillejos-Lopez MD. Genetic polymorphism of the TNF promoter region and the susceptibility to develop Hodgkin's lymphoma in a Mexican population. Leuk Lymphoma. 2013 Sep 16; 55(6):1295-9.

• Torres Espindola LM, Arellano Galindo J, Velazquez Cruz R, Castillejos Lopez Mde J. Factores que participan en la interaccion huesped-agente patogeno en el riesgo de Linfoma de Hodgkin inducido por el virus Epstein Barr.. Invest Clin. 2013 Sep; 54(3):311-24.

• Falcon-Ramirez E, Casas-Avila L, Cerda-Flores RM, Castro-Hernandez C, Rubio-Lightbourn J, Velazquez-Cruz R, Diez-G P, Penaloza-Espinosa R, Valdes-Flores M. Association of LRP5 haplotypes with osteoporosis in Mexican women. Mol Biol Rep. 2012 Dec 16; 40:2705-2710.

• Ramirez-Bello J, Jimenez-Morales S, Espinosa-Rosales F, Gomez-Vera J, Gutierrez A, Velazquez Cruz R, Baca V, Orozco L. Juvenile rheumatoid arthritis and asthma, but not childhood-onset systemic lupus erythematosus are associated with FCRL3 polymorphisms in Mexicans. Mol Immunol. 2013 Apr; 53(4):374-8.

• Jimenez-Morales S, Gamboa-Becerra R, Baca V, Del Rio-Navarro BE, Lopez-Ley DY, Velazquez-Cruz R, Saldana-Alvarez Y, Salas-Martinez G, Orozco L. MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients. Tissue Antigens. 2012 Jul 24; 80(4):317-21.

• Velazquez-Cruz R, Jimenez-Morales S, Ramirez-Bello J, Aguilar-Delfin I, Salas-Martinez G, Baca Ruiz V, Orozco Orozco L. Lupus eritematoso sistemico (LES): genomica de la enfermedad. Gac Med Mex. 2012 Jul-Aug; 148(4):371-80.

• Cordova EJ, Martinez-Hernandez A, Ramirez-Bello J, Velazquez-Cruz R, Centeno F, Baca V, Orozco L. HMOX1 promoter (GT)n polymorphim is associated with childhood-onset systemic lupus erythematosus but not with juvenile rheumatoid arthritis in a Mexican population. Clin Exp Rheumatol. 2012 Mar-Apr; 30(2):297-301.

• Saldana-Alvarez Y, Jimenez-Morales S, Echevarria-Sanchez M, Jimenez-Ruiz JL, Garcia-Cavazos R, Velazquez-Cruz R, Carnevale A, Orozco L. Molecular Screening of the CFTR Gene in Mexican Patients with Congenital Absence of the Vas Deferens. Genet Test Mol Biomarkers. 2012 Apr; 16(4):292-6.

• Agueda L, Velazquez-Cruz R, Urreizti R, Yoskovitz G, Sarrion P, Jurado S, Guerri R, Garcia-Giralt N, Nogues X, Mellibovsky L, Diez-Perez A, Marie PJ, Balcells S, Grinberg D. Functional relevance of the BMD-associated polymorphism rs312009: novel involvement of RUNX2 in LRP5 transcriptional regulation. J Bone Miner Res. 2011 May; 26(5):1133-44.

• Garcia-Ortiz H, Velazquez-Cruz R, Espinosa-Rosales F, Jimenez-Morales S, Baca V, Orozco L. Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population. Ann Rheum Dis. 2010 Oct; 69(10):1861-5.

• Cordova EJ, Velazquez-Cruz R, Centeno F, Baca V, Orozco L. The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus. Lupus. 2010 Sep; 19(10):1237-42.

• Jimenez-Morales S, Velazquez-Cruz R, Ramirez-Bello J, Bonilla-Gonzalez E, Romero-Hidalgo S, Escamilla-Guerrero G, Cuevas F, Espinosa-Rosales F, Martinez-Aguilar NE, Gomez-Vera J, Baca V, Orozco L. Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population. Hum Immunol. 2009 Apr; 70(4):251-6.

• Checa M, Ruiz V, Montano M, Velazquez-Cruz R, Selman M, Pardo A. MMP-1 polymorphisms and the risk of idiopathic pulmonary fibrosis. Hum Genet. 2008 Dec; 124(5):465-72.

• Abelson AK, Delgado-Vega AM, Kozyrev SV, Sanchez E, Velazquez-Cruz R, Eriksson N, Wojcik J, Linga Reddy MV, Lima G, D'Alfonso S, Migliaresi S, Baca V, Orozco L, Witte T, Ortego-Centeno N, Abderrahim H, Pons-Estel BA, Gutierrez C, Suarez A, Gonzalez-Escribano MF, Martin J, Alarcon-Riquelme ME. STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk. Ann Rheum Dis. 2008 Nov; 68(11):1746-53.

• Jimenez-Morales S, Miranda-Peralta E, Saldana-Alvarez Y, Perez-Vera P, Paredes-Aguilera R, Rivera-Luna R, Velazquez-Cruz R, Ramirez-Bello J, Carnevale A, Orozco L. BCR-ABL, ETV6-RUNX1 and E2A-PBX1: prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients. Leuk Res. 2008 Oct; 32(10):1518-22.

• Reddy MV, Velazquez-Cruz R, Baca V, Lima G, Granados J, Orozco L, Alarcon-Riquelme ME. Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans. Hum Genet. 2007 Jul; 121(6):721-7.

• Velazquez-Cruz R, Orozco L, Espinosa-Rosales F, Carreno-Manjarrez R, Solis-Vallejo E, Lopez-Lara ND, Ruiz-Lopez IK, Rodriguez-Lozano AL, Estrada-Gil JK, Jimenez-Sanchez G, Baca V. Association of PDCD1 polymorphisms with childhood-onset systemic lupus erythematosus. Eur J Hum Genet. 2007 Mar; 15(3):336-41.

• Baca V, Velazquez-Cruz R, Salas-Martinez G, Espinosa-Rosales F, Saldana-Alvarez Y, Orozco L. Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population. Genes Immun. 2006 Dec; 7(8):693-5.

Estancia Posdoctoral

• Adriana Becerra Cervera
• Rogelio Frank Jiménez Ortega

Tesista de Doctorado

• Anna Deaicy Argoty Pantoja

Tesista de Licenciatura

• Noemí Yusaleth Martínez Ibarra
• Samantha Carrasco Trejo
• Tomas Yescas Romero

Servicio Social

• José Luis Segura Córdova
• Rubi Daniela Lozano Lino

Estancia Voluntaria

• Claudia Romero Chávez
• Jessica Ariadna Rodríguez Martínez
• Michell Elizabeth García Espinosa
• Sergio Rafael Carrillo Patiño

Práctica Profesional

• Michelle Reyes Reyes

En curso

• BUSQUEDA DE MARCADORES BIOLÓGICOS DEL REMODELADO ÓSEO PARA EL DIAGNÓSTICO DE LA OSTEOPOROSIS
• Caracterización de la composición y diversidad de la microbiota intestinal: impacto en la pérdida de la masa ósea y sus principales complicaciones.
• IDENTIFICACIÓN DE SNPS ASOCIADOS CON LOS NIVELES DE VITAMINA D, EN EL ESTUDIO DE COHORTE DE TRABAJADORES DE LA SALUD Y UN PANORAMA DE SU DISTRIBUCIÓN EN GRUPOS INDÍGENAS DE MÉXICO.

Terminados

• Análisis de expresión de microRNAs en suero de mujeres postmenopáusicas: búsqueda de biomarcadores no invasivos del metabolismo óseo para el diagnóstico de la osteoporosis
• Análisis de Haplotipos y prevalencia de la mutación c.1987delC en el Gen GAA causante de la enfermedad de Pompe en individuos de comunidades en aislamiento genético en la Zona Huasteca de San Luis Potosí
• Análisis de perfiles de expresión de miRNAs en pacientes con osteosarcoma y su potencial aplicación como herramienta de diagnóstico.
• Asociación de Polimorfismos en genes candidato con la susceptibilidad, gravedad y respuesta al tratamiento en población infantil mexicana con Asma
• Densidad mineral ósea y osteoporosis en mujeres mexicanas: estudio de asociación de genoma completo.
• Factores genéticos amerindios y variantes raras que contribuyen al desarrollo de la diabetes mellitus tipo 2 en familias indígenas rurales de la Cd. de México.
• Identificación de biomarcadores asociados a la variación de la Densidad Mineral Ósea mediante análisis de miRNAs en monocitos circulantes de sangre periférica en mujeres postmenopáusicas mexicanas.
• Identificación de microRNAs involucrados en la diferenciación de monocitos a osteoclastos y su papel en la variación de la densidad mineral Ósea.
• Identificación de proteínas del remodelado óseo como nuevos marcadores: análisis integrativo de proteómica y transcriptómica en osteoporosis.
• Impacto de factores genéticos y ambientales en la Susceptibilidad a Enfermedad Hepática en una cohorte de adultos mexicanos
• PARTICIPACIÓN DE LOS GENES DE LA CAPTACIÓN, SÍNTESIS Y BIOTRANSFORMACIÓN DEL COLESTEROL EN LA PROGRESIÓN DE ESTEATOSIS A ESTEATOHEPATITIS EN SUJETOS OBESOS
• Polimorfismos en genes candidatos y su asociación con lupus eritematoso sistémico de inicio en la edad pediátrica.
• Polimorfismos en genes de la ruta de señalización WNT y su asociación en la variación de la densidad mineral ósea (DMO) en pacientes con Osteoporosis