Seminar “Structural and Sequence Factors, determinants of amyloid aggregation of light chains


Mexico City / Friday, May 21, 2011

On Friday, May 21, was held in the Aula Magna of the National Institute of Genomic Medicine (INMEGEN), the Seminar: “Structural and Sequence Factors, determinants of amyloid aggregation of light chains”,  by Dr. Luis del Pozo Yauner, Researcher of INMEGEN.

Dr. Jorge Melendez Zajgla, Chief of the Laboratory of Functional Genomics Cancer at INMEGEN, welcomed attendees and noted that laboratory objectives are to generate appropriate treatments based on knowledge acquired and derived data for optimal use in clinical practice.

Subsequently, Dr. Luis del Pozo, an expert in the study of amyloid aggregation,started defining the amyloid, which are a group of chemical entities that share specific structural features. He explained that the abnormal accumulation of amyloid in organs can lead to amyloidosis, which is a protein metabolism disorder characterized by the extracellular deposition of fibrillar protein material with a tertiary molecular structure of β-folded arrangement. This molecular structure is responsible for the insolubility of the amyloid deposits and its resistance to proteolytic digestion.

He also presented several experiments, where found common fragments within the peptide sequences, which help the reaggregation of amyloid that is a basic principle for storage diseases such as amyloidosis.

Finally, Dr. Jorge Melendez thanked the assistance of the Institute’s scientific community and the institutions connected through the Internet, especially to a group of executives from the Human Genome Organisation (HUGO), linked from Montpellier, France.

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