Sitio del Instituto Nacional de Medicina Genómica




Curriculum Vitae

Dr. Francisco Martin Barajas Olmos

Dr. Francisco Martin Barajas Olmos

Investigador en Ciencias Médicas C
None ext.None
fbarajas@inmegen.gob.mx

Obtuvo la Licenciatura como Químico Farmacéutico Biólogo de la Facultad de Química de la Universidad de Guanajuato; obtuvo el Doctorado en Ciencias en Biomédicas de la Facultad de Medicina en la Universidad Nacional Autónoma de México. Actualmente es Investigador en Ciencias Médicas “A”, adscrito al laboratorio Inmunogenómica y de Enfermedades Metabólicas del INMEGEN.

Desde el 2016 colabora en la línea de investigación de la Genómica de Enfermedades Metabólicas englobando proyectos dirigidos a entender la predisposición de la población mexicana al desarrollo de las enfermedades metabólicas. En esta línea ha tenido contribuciones importantes, tales como la publicación en fechas recientes de las marcas epigenéticas afectadas en el tejido adiposo de pacientes diabéticos.

En los últimos 3 (2016-2018) años ha publicado 7 artículos de investigación en revistas internacionales. Muchos de los resultados de los temas mencionados se han publicado en revistas del más alto impacto, tales como Cell y Diabetes, además cuenta con mas de 100 citas en este mismo periodo.

Artículos

  • Mirzaeicheshmeh E, Zerrweck C, Centeno-Cruz F, Baca-Peynado P, Martinez-Hernandez A, Garcia-Ortiz H, Contreras-Cubas C, Salas-Martinez MG, Saldana-Alvarez Y, Mendoza-Caamal EC, Barajas-Olmos F, Orozco L. Alterations of DNA methylation during adipogenesis differentiation of mesenchymal stem cells isolated from adipose tissue of patients with obesity is associated with type 2 diabetes. Adipocyte. 2021 Dec; 10(1):493-504.

  • Morales-Rivera MI, Alemon-Medina R, Martinez-Hernandez A, Gomez-Garduno J, Mirzaeicheshmeh E, Altamirano-Bustamante NF, Ilizaliturri-Flores I, Mendoza-Caamal EC, Perez-Guille MG, Garcia-Alvarez R, Contreras-Cubas C, Centeno-Cruz F, Revilla-Monsalve C, Garcia-Ortiz H, Barajas-Olmos F, Orozco L. The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate. Biomed Pharmacother. 2021 Oct; 142:112009.

  • Mendoza-Caamal EC, Barajas-Olmos F, Mirzaeicheshmeh E, Ilizaliturri-Flores I, Aguilar-Salinas CA, Gomez-Velasco DV, Ciceron-Arellano I, Resendiz-Rodriguez A, Martinez-Hernandez A, Contreras-Cubas C, Islas-Andrade S, Zerrweck C, Garcia-Ortiz H, Orozco L. Two novel variants in DYRK1B causative of AOMS3: expanding the clinical spectrum. Orphanet J Rare Dis. 2021 Jun 30; 16(1):291.

  • Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, Dornbos P, Koesterer R, Zappala Z, Zhang H, Maloney KA, Dahl A, Aguilar-Salinas CA, Atzmon G, Barajas-Olmos F, Barzilai N, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Centeno-Cruz F, Chambers JC, Chami N, Chan E, Chan J, Cheng CY, Cho YS, Contreras-Cubas C, Cordova E, Correa A, DeFronzo RA, Duggirala R, Dupuis J, Garay-Sevilla ME, Garcia-Ortiz H, Gieger C, Glaser B, Gonzalez-Villalpando C, Gonzalez ME, Grarup N, Groop L, Gross M, Haiman C, Han S, Hanis CL, Hansen T, Heard-Costa NL, Henderson BE, Hernandez JMM, Hwang MY, Islas-Andrade S, Jorgensen ME, Kang HM, Kim BJ, Kim YJ, Koistinen HA, Kooner JS, Kuusisto J, Kwak SH, Laakso M, Lange L, Lee JY, Lee J, Lehman DM, Linneberg A, Liu J, Loos RJF, Lyssenko V, Ma RCW, Martinez-Hernandez A, Meigs JB, Meitinger T, Mendoza-Caamal E, Mohlke KL, Morris AD, Morrison AC, Ng MCY, Nilsson PM, O'Donnell CJ, Orozco L, Palmer CNA, Park KS, Post WS, Pedersen O, Preuss M, Psaty BM, Reiner AP, Revilla-Monsalve C, Rich SS, Rotter JI, Saleheen D, Schurmann C, Sim X, Sladek R, Small KS, So WY, Spector TD, Strauch K, Strom TM, Tai ES, Tam CHT, Teo YY, Thameem F, Tomlinson B, Tracy RP, Tuomi T, Tuomilehto J, Tusie-Luna T, van Dam RM, Vasan RS, Wilson JG, Witte DR, Wong TY, Burtt NP, Zaitlen N, McCarthy MI, Boehnke M, Pollin TI, Flannick J, Mercader JM, O'Donnell-Luria A, Baxter S, Florez JC, MacArthur DG, Udler MS. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nat Commun. 2021 Jun 9; 12(1):3505.

  • Wibowo MC, Yang Z, Borry M, Hubner A, Huang KD, Tierney BT, Zimmerman S, Barajas-Olmos F, Contreras-Cubas C, Garcia-Ortiz H, Martinez-Hernandez A, Luber JM, Kirstahler P, Blohm T, Smiley FE, Arnold R, Ballal SA, Pamp SJ, Russ J, Maixner F, Rota-Stabelli O, Segata N, Reinhard K, Orozco L, Warinner C, Snow M, LeBlanc S, Kostic AD. Reconstruction of ancient microbial genomes from the human gut. Nature. 2021 Jun; 594(7862):234-239.

  • Aguilar-Ordonez I, Perez-Villatoro F, Garcia-Ortiz H, Barajas-Olmos F, Ballesteros-Villascan J, Gonzalez-Buenfil R, Fresno C, Garciarrubio A, Fernandez-Lopez JC, Tovar H, Hernandez-Lemus E, Orozco L, Soberon X, Morett E. Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights. PLoS One. 2021; 16(4):e0249773.

  • Rodriguez-Ayala E, Gallegos-Cabrales EC, Gonzalez-Lopez L, Laviada-Molina HA, Salinas-Osornio RA, Nava-Gonzalez EJ, Leal-Berumen I, Escudero-Lourdes C, Escalante-Araiza F, Buenfil-Rello FA, Peschard VG, Laviada-Nagel A, Silva E, Veloz-Garza RA, Martinez-Hernandez A, Barajas-Olmos FM, Molina-Segui F, Gonzalez-Ramirez L, Espadas-Olivera R, Lopez-Munoz R, Arjona-Villicana RD, Hernandez-Escalante VM, Rodriguez-Arellano ME, Gaytan-Saucedo JF, Vaquera Z, Acebo-Martinez M, Cornejo-Barrera J, Huertas-Quintero JA, Castillo-Pineda JC, Murillo-Ramirez A, Diaz-Tena SP, Figueroa-Nunez B, Valencia-Rendon ME, Garzon-Zamora R, Viveros-Paredes JM, Angeles-Chimal J, Santa-Olalla Tapia J, Remes-Troche JM, Valdovinos-Chavez SB, Huerta-Avila EE, Lopez-Alvarenga JC, Comuzzie AG, Haack K, Han X, Orozco L, Weintraub S, Kent JW, Cole SA, Bastarrachea RA. Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study. Adipocyte. 2020 Dec; 9(1):153-169.

  • Mendoza-Caamal EC, Barajas-Olmos F, Garcia-Ortiz H, Ciceron-Arellano I, Martinez-Hernandez A, Cordova EJ, Esparza-Aguilar M, Contreras-Cubas C, Centeno-Cruz F, Cid-Soto M, Morales-Marin ME, Resendiz-Rodriguez A, Jimenez-Ruiz JL, Salas-Martinez MG, Saldana-Alvarez Y, Mirzaeicheshmeh E, Rojas-Martinez MR, Orozco L. Metabolic syndrome in indigenous communities in Mexico: a descriptive and cross-sectional study. BMC Public Health. 2020 Mar 17; 20(1):339.

  • Salas-Martinez MG, Saldana-Alvarez Y, Cordova EJ, Mendiola-Soto DK, Cid-Soto MA, Luckie-Duque A, Vicenteno-Ayala H, Barajas-Olmos F, Contreras-Cubas C, Garcia-Ortiz H, Jimenez-Ruiz JL, Centeno-Cruz F, Martinez-Hernandez A, Mendoza-Caamal EC, Mirzaeicheshmeh E, Orozco L. Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population. PLoS One. 2019; 14(12):e0225030.

  • Gonzalez-Covarrubias V, Morales-Franco M, Cruz-Correa OF, Martinez-Hernandez A, Garcia-Ortiz H, Barajas-Olmos F, Genis-Mendoza AD, Martinez-Magana JJ, Nicolini H, Orozco L, Soberon X. Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico. Front Pharmacol. 2019; 10:1169.

  • Contreras-Cubas C, Garcia-Ortiz H, Velazquez-Cruz R, Barajas-Olmos F, Baca P, Martinez-Hernandez A, Barbosa-Cobos RE, Ramirez-Bello J, Lopez-Hernandez MA, Svyryd Y, Mutchinick OM, Baca V, Orozco L. Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans. Sci Rep. 2019 Aug 21; 9(1):12165.

  • Barajas-Olmos FM, Ortiz-Sanchez E, Imaz-Rosshandler I, Cordova-Alarcon EJ, Martinez-Tovar A, Villanueva-Toledo J, Morales-Marin ME, Cruz-Colin JL, Rangel C, Orozco L, Centeno F. Analysis of the dynamic aberrant landscape of DNA methylation and gene expression during arsenic-induced cell transformation. Gene. 2019 Aug 30; 711:143941.

  • Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, Contreras-Cubas C, Cordova E, Correa A, Cortes M, DeFronzo RA, Dolan L, Drews KL, Elliott A, Floyd JS, Gabriel S, Garay-Sevilla ME, Garcia-Ortiz H, Gross M, Han S, Heard-Costa NL, Jackson AU, Jorgensen ME, Kang HM, Kelsey M, Kim BJ, Koistinen HA, Kuusisto J, Leader JB, Linneberg A, Liu CT, Liu J, Lyssenko V, Manning AK, Marcketta A, Malacara-Hernandez JM, Martinez-Hernandez A, Matsuo K, Mayer-Davis E, Mendoza-Caamal E, Mohlke KL, Morrison AC, Ndungu A, Ng MCY, O'Dushlaine C, Payne AJ, Pihoker C, Post WS, Preuss M, Psaty BM, Vasan RS, Rayner NW, Reiner AP, Revilla-Monsalve C, Robertson NR, Santoro N, Schurmann C, So WY, Soberon X, Stringham HM, Strom TM, Tam CHT, Thameem F, Tomlinson B, Torres JM, Tracy RP, van Dam RM, Vujkovic M, Wang S, Welch RP, Witte DR, Wong TY, Atzmon G, Barzilai N, Blangero J, Bonnycastle LL, Bowden DW, Chambers JC, Chan E, Cheng CY, Cho YS, Collins FS, de Vries PS, Duggirala R, Glaser B, Gonzalez C, Gonzalez ME, Groop L, Kooner JS, Kwak SH, Laakso M, Lehman DM, Nilsson P, Spector TD, Tai ES, Tuomi T, Tuomilehto J, Wilson JG, Aguilar-Salinas CA, Bottinger E, Burke B, Carey DJ, Chan JCN, Dupuis J, Frossard P, Heckbert SR, Hwang MY, Kim YJ, Kirchner HL, Lee JY, Lee J, Loos RJF, Ma RCW, Morris AD, O'Donnell CJ, Palmer CNA, Pankow J, Park KS, Rasheed A, Saleheen D, Sim X, Small KS, Teo YY, Haiman C, Hanis CL, Henderson BE, Orozco L, Tusie-Luna T, Dewey FE, Baras A, Gieger C, Meitinger T, Strauch K, Lange L, Grarup N, Hansen T, Pedersen O, Zeitler P, Dabelea D, Abecasis G, Bell GI, Cox NJ, Seielstad M, Sladek R, Meigs JB, Rich SS, Rotter JI, Altshuler D, Burtt NP, Scott LJ, Morris AP, Florez JC, McCarthy MI, Boehnke M. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019 Jun; 570(7759):71-76.

  • Martinez-Hernandez A, Larrosa J, Barajas-Olmos F, Garcia-Ortiz H, Mendoza-Caamal EC, Contreras-Cubas C, Mirzaeicheshmeh E, Lezana JL, Orozco L. Next-generation sequencing for identifying a novel/de novo pathogenic variant in a Mexican patient with cystic fibrosis: a case report. BMC Med Genomics. 2019 May 22; 12(1):68.

  • Reynolds AW, Mata-Miguez J, Miro-Herrans A, Briggs-Cloud M, Sylestine A, Barajas-Olmos F, Garcia-Ortiz H, Rzhetskaya M, Orozco L, Raff JA, Hayes MG, Bolnick DA. Comparing signals of natural selection between three Indigenous North American populations. Proc Natl Acad Sci USA. 2019 Apr 15; 116:.

  • Bastarrachea RA, Laviada-Molina HA, Nava-Gonzalez EJ, Leal-Berumen I, Escudero-Lourdes C, Escalante-Araiza F, Peschard VG, Veloz-Garza RA, Haack K, Martinez-Hernandez A, Barajas-Olmos FM, Molina-Segui F, Buenfil-Rello FA, Gonzalez-Ramirez L, Janssen-Aguilar R, Lopez-Munoz R, Perez-Cetina F, Gaytan-Saucedo JF, Vaquera Z, Cornejo-Barrera J, Castillo-Pineda JC, Murillo-Ramirez A, Diaz-Tena SP, Figueroa-Nunez B, Gonzalez-Lopez L, Salinas-Osornio RA, Valencia-Rendon ME, Angeles-Chimal J, Santa-Olalla Tapia J, Remes-Troche JM, Valdovinos-Chavez SB, Huerta-Avila EE, Han X, Orozco L, Rodriguez-Ayala E, Weintraub S, Gallegos-Cabrales EC, Cole SA, Kent JW Jr. Deep Multi-OMICs and Multi-Tissue Characterization in a Pre- and Postprandial State in Human Volunteers: The GEMM Family Study Research Design. Genes (Basel). 2018 Nov 2; 9(11):.

  • Cid-Soto MA, Martinez-Hernandez A, Garcia-Ortiz H, Cordova EJ, Barajas-Olmos F, Centeno-Cruz F, Contreras-Cubas C, Mendoza-Caamal EC, Ciceron-Arellano I, Morales-Rivera MI, Jimenez-Ruiz JL, Salas-Martinez G, Saldana-Alvarez Y, Revilla-Monsalve C, Islas-Andrade S, Orozco L. Gene variants in AKT1, GCKR and SOCS3 are differentially associated with metabolic traits in Mexican Amerindians and Mestizos. Gene. 2018 Dec 30; 679:160-171.

  • Mercader JM, Liao RG, Bell AD, Dymek Z, Estrada K, Tukiainen T, Huerta-Chagoya A, Moreno-Macias H, Jablonski KA, Hanson RL, Walford GA, Moran I, Chen L, Agarwala V, Ordonez-Sanchez ML, Rodriguez-Guillen R, Rodriguez-Torres M, Segura-Kato Y, Garcia-Ortiz H, Centeno-Cruz F, Barajas-Olmos F, Caulkins L, Puppala S, Fontanillas P, Williams AL, Bonas-Guarch S, Hartl C, Ripke S, Tooley K, Lane J, Zerrweck C, Martinez-Hernandez A, Cordova EJ, Mendoza-Caamal E, Contreras-Cubas C, Gonzalez-Villalpando ME, Cruz-Bautista I, Munoz-Hernandez L, Gomez-Velasco D, Alvirde U, Henderson BE, Wilkens LR, Le Marchand L, Arellano-Campos O, Riba L, Harden M, Gabriel S, Abboud HE, Cortes ML, Revilla-Monsalve C, Islas-Andrade S, Soberon X, Curran JE, Jenkinson CP, DeFronzo RA, Lehman DM, Hanis CL, Bell GI, Boehnke M, Blangero J, Duggirala R, Saxena R, MacArthur D, Ferrer J, McCarroll SA, Torrents D, Knowler WC, Baier LJ, Burtt N, Gonzalez-Villalpando C, Haiman CA, Aguilar-Salinas CA, Tusie-Luna T, Flannick J, Jacobs SBR, Orozco L, Altshuler D, Florez JC. A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes. Diabetes. 2017 Nov; 66(11):2903-2914.


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