Artículos

• Martinez-Hernandez A, Mendoza-Caamal EC, Mendiola-Vidal NG, Barajas-Olmos F, Villafan-Bernal JR, Jimenez-Ruiz JL, Monge-Cazares T, Garcia-Ortiz H, Cubas CC, Centeno-Cruz F, Alaez-Verson C, Ortega-Torres S, Luna-Castaneda ADC, Baca V, Lezana JL, Orozco L. CFTR pathogenic variants spectrum in a cohort of Mexican patients with cystic fibrosis. Heliyon. 2024 Apr 15; 10(7):e28984.

• Garcia-Solorio J, Martinez-Villegas O, Rodriguez-Corona U, Molina-Garay C, Jimenez-Olivares M, Carrillo-Sanchez K, Mendoza-Caamal EC, Munoz-Rivas A, Villegas-Torres BE, Cervera A, Flores-Lagunes LL, Alaez-Verson C. Case report: A familial B-acute lymphoblastic leukemia associated with a new germline pathogenic variant in PAX5. The first report in Mexico. Front Oncol. 2024; 14:1355335.

• Alonso-Luna O, Mercado-Celis GE, Melendez-Zajgla J, Barquera R, Zapata-Tarres M, Juarez-Villegas LE, Mendoza-Caamal EC, Rey-Helo E, Borges-Yanez SA. Germline mutations in pediatric cancer cohort with mixed-ancestry Mexicans. Mol Genet Genomic Med. 2024 Jan; 12(1):e2332.

• Jurado-Camacho PA, Cid-Soto MA, Barajas-Olmos F, Garcia-Ortiz H, Baca-Peynado P, Martinez-Hernandez A, Centeno-Cruz F, Contreras-Cubas C, Gonzalez-Villalpando ME, Saldana-Alvarez Y, Salas-Martinez G, Mendoza-Caamal EC, Gonzalez-Villalpando C, Cordova EJ, Orozco L. Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated Loci. Front Genet. 2022; 13:807381.

• Mirzaeicheshmeh E, Zerrweck C, Centeno-Cruz F, Baca-Peynado P, Martinez-Hernandez A, Garcia-Ortiz H, Contreras-Cubas C, Salas-Martinez MG, Saldana-Alvarez Y, Mendoza-Caamal EC, Barajas-Olmos F, Orozco L. Alterations of DNA methylation during adipogenesis differentiation of mesenchymal stem cells isolated from adipose tissue of patients with obesity is associated with type 2 diabetes. Adipocyte. 2021 Dec; 10(1):493-504.

• Garcia-Ortiz H, Barajas-Olmos F, Contreras-Cubas C, Cid-Soto MA, Cordova EJ, Centeno-Cruz F, Mendoza-Caamal E, Ciceron-Arellano I, Flores-Huacuja M, Baca P, Bolnick DA, Snow M, Flores-Martinez SE, Ortiz-Lopez R, Reynolds AW, Blanchet A, Morales-Marin M, Velazquez-Cruz R, Kostic AD, Galaviz-Hernandez C, Garcia-Zapien AG, Jimenez-Lopez JC, Leon-Reyes G, Salas-Bautista EG, Lazalde-Ramos BP, Jimenez-Ruiz JL, Salas-Martinez G, Ramos-Madrigal J, Mirzaeicheshmeh E, Saldana-Alvarez Y, Del Carmen Abrahantes-Perez M, Loeza-Becerra F, Mojica-Espinosa R, Sanchez-Quinto F, Rangel-Villalobos H, Sosa-Macias M, Sanchez-Corona J, Rojas-Martinez A, Martinez-Hernandez A, Orozco L. The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas. Nat Commun. 2021 Oct 12; 12(1):5942.

• Morales-Rivera MI, Alemon-Medina R, Martinez-Hernandez A, Gomez-Garduno J, Mirzaeicheshmeh E, Altamirano-Bustamante NF, Ilizaliturri-Flores I, Mendoza-Caamal EC, Perez-Guille MG, Garcia-Alvarez R, Contreras-Cubas C, Centeno-Cruz F, Revilla-Monsalve C, Garcia-Ortiz H, Barajas-Olmos F, Orozco L. The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate. Biomed Pharmacother. 2021 Oct; 142:112009.

• Mendoza-Caamal EC, Barajas-Olmos F, Mirzaeicheshmeh E, Ilizaliturri-Flores I, Aguilar-Salinas CA, Gomez-Velasco DV, Ciceron-Arellano I, Resendiz-Rodriguez A, Martinez-Hernandez A, Contreras-Cubas C, Islas-Andrade S, Zerrweck C, Garcia-Ortiz H, Orozco L. Two novel variants in DYRK1B causative of AOMS3: expanding the clinical spectrum. Orphanet J Rare Dis. 2021 Jun 30; 16(1):291.

• Mendoza-Caamal EC, Barajas-Olmos F, Garcia-Ortiz H, Ciceron-Arellano I, Martinez-Hernandez A, Cordova EJ, Esparza-Aguilar M, Contreras-Cubas C, Centeno-Cruz F, Cid-Soto M, Morales-Marin ME, Resendiz-Rodriguez A, Jimenez-Ruiz JL, Salas-Martinez MG, Saldana-Alvarez Y, Mirzaeicheshmeh E, Rojas-Martinez MR, Orozco L. Metabolic syndrome in indigenous communities in Mexico: a descriptive and cross-sectional study. BMC Public Health. 2020 Mar 17; 20(1):339.

• Salas-Martinez MG, Saldana-Alvarez Y, Cordova EJ, Mendiola-Soto DK, Cid-Soto MA, Luckie-Duque A, Vicenteno-Ayala H, Barajas-Olmos F, Contreras-Cubas C, Garcia-Ortiz H, Jimenez-Ruiz JL, Centeno-Cruz F, Martinez-Hernandez A, Mendoza-Caamal EC, Mirzaeicheshmeh E, Orozco L. Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population. PLoS One. 2019; 14(12):e0225030.

• Martinez-Hernandez A, Larrosa J, Barajas-Olmos F, Garcia-Ortiz H, Mendoza-Caamal EC, Contreras-Cubas C, Mirzaeicheshmeh E, Lezana JL, Orozco L. Next-generation sequencing for identifying a novel/de novo pathogenic variant in a Mexican patient with cystic fibrosis: a case report. BMC Med Genomics. 2019 May 22; 12(1):68.

• Cid-Soto MA, Martinez-Hernandez A, Garcia-Ortiz H, Cordova EJ, Barajas-Olmos F, Centeno-Cruz F, Contreras-Cubas C, Mendoza-Caamal EC, Ciceron-Arellano I, Morales-Rivera MI, Jimenez-Ruiz JL, Salas-Martinez G, Saldana-Alvarez Y, Revilla-Monsalve C, Islas-Andrade S, Orozco L. Gene variants in AKT1, GCKR and SOCS3 are differentially associated with metabolic traits in Mexican Amerindians and Mestizos. Gene. 2018 Dec 30; 679:160-171.

• Martagón AJ., Bello-Chavolla OY., Arellano-Campos O., Almeda-Valdés P., Walford GA., Cruz-Bautista I., Gómez-Velasco DV., Mehta R., Muñoz-Hernández L., Sevilla-González M., Viveros-Ruiz TL., Ordoñez-Sánchez ML., Rodríguez-Guillen R., Florez JC., Tusié-Luna MT., Aguilar-Salinas CA, Mercader JM., Huerta-Chagoya A., Moreno-Macías H., García-Ortiz H., Manning A., Caulkins L., Flannick J., Patterson N., Martínez-Hernández A., Centeno-Cruz F., Barajas-Olmos FM., Zerrweck C., Contreras-Cubas C., Mendoza-Caamal E., Revilla-Monsalve C., Islas Andrade S., Córdova E, . Soberón X., González-Villalpando ME., Wilkens L., Le Marchand L., Monroe K., Kolonel L., Rodríguez-Torres M., Segura-Kato Y., Muñoz-Hernández LL, Martagón AJ, Sevilla Gonzalez MDR, Gómez D, Almeda-Valdés P, Garay ME, Malacara Hernandez JM, Burtt NP, Cortes ML, Altshuler DM, Haiman CA, González-Villalpando C, Orozco L., Tusié-Luna T. Mexican Carriers of the HNF1A p.E508K Variant Do Not Experience an Enhanced Response to Sulfonylureas. Am J Med Genet. 2018; 41(8):.

Servicio Social

• Andrea Citlali Lagos Ortíz

Estancia Voluntaria

• Hakim García Chávez

En curso

• DIVERSIDAD GENÓMICA Y VARIANTES RARAS QUE CONTRIBUYEN AL DESARROLLO DE LAS ENFERMEDADES CRÓNICO-DEGENERATIVAS EN LOS GRUPOS INDÍGENAS DEL TERRITORIO MEXICANO
• IDENTIFICACIÓN DE BIOMARCADORES DE SUSCEPTIBILIDAD PARA DIABETES MELLITUS TIPO 2 Y OBESIDAD, MEDIANTE LA CARACTERIZACIÓN DE PERFILES DE EXPRESIÓN, EPIGENÓMICOS Y METABOLÓMICOS.
• Identificación del espectro total de mutaciones del gen CFTR y asociación de genes modificadores con la gravedad de fibrosis quística en pacientes mexicanos
• Identificación de Variantes Patogénicas Responsables de Errores Innatos del Metabolismo en Población Mexicana: Frecuencia de Portadores y Estimación de Prevalencia

Terminados

• DIABETES MÉXICO Iniciativa del Instituto Carlos Slim para la Salud