Dr. Mauricio Rodríguez Dorantes

ÁREAS DE INVESTIGACIÓN: Endocrinología, Biología de la Reproducción, Epigenética y Biología Molecular

LÍNEA DE INVESTIGACIÓN: Mecanismos moleculares y epigenéticos en el desarrollo del Cáncer de Próstata 

Las líneas de investigación en su grupo se centran sobre los mecanismos moleculares y epigenéticos involucrados en el desarrollo del cáncer particularmente el de próstata. El Dr. Rodríguez es autor de más de 39 publicaciones en revistas indizadas y publicado 4 capítulos de libro internacionales y 2 nacionales. El grupo del Dr. Rodríguez ha obtenido diversos reconocimientos, entre los que destacan: El Premio de la Fundación Aida –Weiss UNAM a la mejor tesis doctoral 2016; Premio a la mejor tesis de Disertación Doctoral en Ciencias Biomédicas “Dr. Hugo Aréchiga Urtuzuástegui” 2016 por la academia de Sinaloa, Premio Puiss UNAM- Gea Gonzáles 2012, premio al mejor trabajo de investigación en el encuentro estudiantil del  INMEGEN 2015. Además ha dirigido 17 tesis de licenciatura, 2 de maestría y 4 de doctorado. Ha realizado múltiples actividades de divulgación de la ciencia y ha participado en la revisión de artículos científicos en revistas indizadas. El Dr. Mauricio Rodríguez es Miembro del Sistema Nacional de Investigadores. Ha sido catedrático en  la U.N.A.M y el Tecnológico de Monterrey. Evaluador de los fondos   PEl, FIT del conacyt  y a nivel internacional para el grupo CORFO (Pfizer-chile). Ha obtenido financiamiento de distintas fuentes (CONACYT, INMEGEN ) siendo el último proyecto de ciencia básica distinguido como uno de los proyectos altamente recomendables en la convocatoria 2018 por CONACYT.

Artículos Destacados

• Garcia-Tobilla P, Solorzano SR, Salido-Guadarrama I, Gonzalez-Covarrubias V, Morales-Montor G, Diaz-Otanez CE, Rodriguez-Dorantes M. SFRP1 repression in prostate cancer is triggered by two different epigenetic mechanisms.. Gene. 2016 Aug 26; :.

• Salido-Guadarrama AI, Morales-Montor JG, Rangel-Escareno C, Langley E, Peralta-Zaragoza O, Cruz Colin JL, Rodriguez-Dorantes M. Urinary microRNA-based signature improves accuracy of detection of clinically relevant prostate cancer within the prostate-specific antigen grey zone. Mol Med Rep. 2016 Apr 8; 13(6):4549-60.

Artículos

• de la Fuente-Mendoza JE, Azorin-Vega EP, Mendoza-Nava HJ, Rodriguez-Martinez G, Rodriguez-Dorantes M. Estimation of the relative biological effectiveness (RBE) of the Lu-DOTA-iPSMA177 radiopharmaceutical. Appl Radiat Isot. 2023 Dec; 202:111065.

• Quintero JC, Diaz NF, Rodriguez-Dorantes M, Camacho-Arroyo I. Cancer Stem Cells and Androgen Receptor Signaling: Partners in Disease Progression. Int J Mol Sci. 2023 Oct 11; 24(20):None.

• Cruz-Burgos M, Cortes-Ramirez SA, Losada-Garcia A, Morales-Pacheco M, Martinez-Martinez E, Morales-Montor JG, Servin-Haddad A, Izquierdo-Luna JS, Rodriguez-Martinez G, Ramos-Godinez MDP, Gonzalez-Covarrubias V, Canavera-Constantino A, Gonzalez-Ramirez I, Su B, Leong HS, Rodriguez-Dorantes M. Unraveling the Role of EV-Derived miR-150-5p in Prostate Cancer Metastasis and Its Association with High-Grade Gleason Scores: Implications for Diagnosis. Cancers (Basel). 2023 Aug 17; 15(16):None.

• Vergara-Geronimo CA, Leon-Del-Rio A, Rodriguez-Dorantes M, Camacho-Carranza R, Ostrosky-Wegman P, Salazar AM. Arsenic reduces the GATA3 expression associated with an increase in proliferation and migration of mammary epithelial cell line MCF-10A. Toxicol Appl Pharmacol. 2023 Aug 1; 472:116573.

• Texis T, Rivera-Mancia S, Colin-Ramirez E, Cartas-Rosado R, Koepsell D, Rubio-Carrasco K, Rodriguez-Dorantes M, Gonzalez-Covarrubias V. Genetic Determinants of Atherogenic Indexes. Genes (Basel). 2023 Jun 1; 14(6):None.

• Nambo-Venegas R, Palacios-Gonzalez B, Mas-Oliva J, Aurioles-Amozurrutia AK, Cruz-Rangel A, Moreno A, Hidalgo-Miranda A, Rodriguez-Dorantes M, Vadillo-Ortega F, Xicohtencatl-Cortes J, Ruiz-Olmedo MI, Reyes-Grajeda JP. Conversion of M1 Macrophages to Foam Cells: Transcriptome Differences Determined by Sex. Biomedicines. 2023 Feb 8; 11(2):None.

• Losada-Garcia A, Salido-Guadarrama I, Cortes-Ramirez SA, Cruz-Burgos M, Morales-Pacheco M, Vazquez-Santillan K, Rodriguez-Martinez G, Gonzalez-Ramirez I, Gonzalez-Covarrubias V, Perez-Plascencia C, Rodriguez-Dorantes M. SFRP1 induces a stem cell phenotype in prostate cancer cells. Front Cell Dev Biol. 2023; 11:1096923.

• Cruz-Hernandez CD, Rodriguez-Martinez G, Cortes-Ramirez SA, Morales-Pacheco M, Cruz-Burgos M, Losada-Garcia A, Reyes-Grajeda JP, Gonzalez-Ramirez I, Gonzalez-Covarrubias V, Camacho-Arroyo I, Cerbon M, Rodriguez-Dorantes M. Aptamers as Theragnostic Tools in Prostate Cancer. Biomolecules. 2022 Jul 29; 12(8):.

• Contreras-Lopez EF, Cruz-Hernandez CD, Cortes-Ramirez SA, Ramirez-Higuera A, Pena-Montes C, Rodriguez-Dorantes M, Oliart-Ros RM. Inhibition of Stearoyl-CoA Desaturase by Sterculic Oil Reduces Proliferation and Induces Apoptosis in Prostate Cancer Cell Lines. Nutr Cancer. 2022 Jul 20; 1:1-14.

• Texis T, Guzman-Cruz C, Rodriguez-Dorantes M, Sanchez-Garcia S, Mino-Leon D, Gonzalez-Covarrubias V. Genotyping NUDT15*3 rs1166855232 reveals higher frequency of potential adverse effects of thiopurines in Natives and Mestizos from Mexico. Pharmacol Rep. 2022 Jun 6; 1:.

• Zamora-Sanchez CJ, Bello-Alvarez C, Rodriguez-Dorantes M, Camacho-Arroyo I. Allopregnanolone Promotes Migration and Invasion of Human Glioblastoma Cells through the Protein Tyrosine Kinase c-Src Activation. Int J Mol Sci. 2022 Apr 30; 23(9):None.

• Contreras-Romero C, Perez-Yepez EA, Martinez-Gutierrez AD, Campos-Parra A, Zentella-Dehesa A, Jacobo-Herrera N, Lopez-Camarillo C, Corredor-Alonso G, Martinez-Coronel J, Rodriguez-Dorantes M, de Leon DC, Perez-Plasencia C. Gene Promoter-Methylation Signature as Biomarker to Predict Cisplatin-Radiotherapy Sensitivity in Locally Advanced Cervical Cancer. Front Oncol. 2022; 12:773438.

• Losada-Garcia A, Cortes-Ramirez SA, Cruz-Burgos M, Morales-Pacheco M, Cruz-Hernandez CD, Gonzalez-Covarrubias V, Perez-Plascencia C, Cerbon MA, Rodriguez-Dorantes M. Hormone-Related Cancer and Autoimmune Diseases: A Complex Interplay to be Discovered. Front Genet. 2021; 12:673180.

• Rodriguez-Dorantes M, Cruz-Hernandez CD, Cortes-Ramirez SA, Cruz-Burgos JM, Reyes-Grajeda JP, Peralta-Zaragoza O, Losada-Garcia A. Prostate Cancer Spheroids: A Three-Dimensional Model for Studying Tumor Heterogeneity. Methods Mol Biol. 2022; 2174:13-17.

• Rodriguez-Dorantes M, Cortes-Ramirez SA, Cruz-Burgos JM, Reyes-Grajeda JP, Losada-Garcia A, Gonzalez-Covarrubias V, Cruz-Hernandez CD. Cell-Internalization SELEX of RNA Aptamers as a Starting Point for Prostate Cancer Research. Methods Mol Biol. 2022; 2174:245-254.

• Cuenca-Mico O, Delgado-Gonzalez E, Anguiano B, Vaca-Paniagua F, Medina-Rivera A, Rodriguez-Dorantes M, Aceves C. Effects of Molecular Iodine/Chemotherapy in the Immune Component of Breast Cancer Tumoral Microenvironment. Biomolecules. 2021 Oct 12; 11(10):.

• Vergara-Geronimo CA, Leon Del Rio A, Rodriguez-Dorantes M, Ostrosky-Wegman P, Salazar AM. Arsenic-protein interactions as a mechanism of arsenic toxicity. Toxicol Appl Pharmacol. 2021 Oct 4; 431:115738.

• Gonzalez-Covarrubias V, Sanchez-Ibarra H, Lozano-Gonzalez K, Villicana S, Texis T, Rodriguez-Dorantes M, Cortes-Ramirez S, Lavalle-Gonzalez F, Soberon X, Barrera-Saldana H. Transporters, TBC1D4, and ARID5B Variants to Explain Glycated Hemoglobin Variability in Patients with Type 2 Diabetes. Pharmacology. 2021 Jul 15; :1-9.

• Velazquez-Vazquez DE, Del Moral-Morales A, Cruz-Burgos JM, Martinez-Martinez E, Rodriguez-Dorantes M, Camacho-Alpharroyo I. Expression analysis of progesteroneregulated miRNAs in cells derived from human glioblastoma. Mol Med Rep. 2021 Jun; 23(6):.

• Flores-Ramirez I, Rivas-Torres MA, Rodriguez-Dorantes M, Gutierrez-Sagal R, Baranda-Avila N, Langley E. Oncogenic role of PinX1 in prostate cancer cells through androgen receptor dependent and independent mechanisms. J Steroid Biochem Mol Biol. 2021 Feb 26; 210:105858.

• Cruz-Burgos M, Losada-Garcia A, Cruz-Hernandez CD, Cortes-Ramirez SA, Camacho-Arroyo I, Gonzalez-Covarrubias V, Morales-Pacheco M, Trujillo-Bornios SI, Rodriguez-Dorantes M. New Approaches in Oncology for Repositioning Drugs: The Case of PDE5 Inhibitor Sildenafil. Front Oncol. 2021; 11:627229.

• Martinez-Ibarra A, Martinez-Razo LD, MacDonald-Ramos K, Morales-Pacheco M, Vazquez-Martinez ER, Lopez-Lopez M, Rodriguez Dorantes M, Cerbon M. Multisystemic alterations in humans induced by bisphenol A and phthalates: Experimental, epidemiological and clinical studies reveal the need to change health policies. Environ Pollut. 2021 Feb 15; 271:116380.

• Lozano-Gonzalez K, Padilla-Rodriguez E, Texis T, Gutierrez MN, Rodriguez-Dorantes M, Cuevas-Cordoba B, Ramirez-Garcia E, Mino-Leon D, Sanchez-Garcia S, Gonzalez-Covarrubias V. Allele Frequency of ACE2 Intron Variants and Its Association with Blood Pressure. DNA Cell Biol. 2020 Nov; 39(11):2095-2101.

• Zamora-Sanchez CJ, Hernandez-Vega AM, Gaona-Dominguez S, Rodriguez-Dorantes M, Camacho-Arroyo I. 5alpha-dihydroprogesterone promotes proliferation and migration of human glioblastoma cells. Steroids. 2020 Jul 28; 163:108708.

• Cruz-Hernandez CD, Cruz-Burgos M, Cortes-Ramirez SA, Losada-Garcia A, Camacho-Arroyo I, Garcia-Lopez P, Langley E, Gonzalez-Covarrubias V, Llaguno-Munive M, Albino-Sanchez ME, Cruz-Colin JL, Perez-Plasencia C, Beltran-Anaya FO, Rodriguez-Dorantes M. SFRP1 increases TMPRSS2-ERG expression promoting neoplastic features in prostate cancer in vitro and in vivo. Cancer Cell Int. 2020; 20:312.

• Barroso-Hernandez A, Ramirez-Higuera A, Pena-Montes C, Cortes-Ramirez SA, Rodriguez-Dorantes M, Lopez-Franco O, Oliart-Ros RM. Beneficial effects of an algal oil rich in omega-3 polyunsaturated fatty acids on locomotor function and D2 dopamine receptor in haloperidol-induced parkinsonism. Nutr Neurosci. 2020 May 18; :1-11.

• Gonzalez-Covarrubias V, Lozano K, Texis T, Guzman-Cruz CK, Rodriguez-Dorantes M, Rubio-Carrasco K, Mendez-Lorenzo LH, Soberon X. Pharmacogenomics: Current Actionable Variants. Rev Invest Clin. 2020 May 7; 72(5):.

• Cabrera-Reyes EA, Vanoye-Carlo A, Rodriguez-Dorantes M, Vazquez-Martinez ER, Rivero-Segura NA, Collazo-Navarrete O, Cerbon M. Transcriptomic analysis reveals new hippocampal gene networks induced by prolactin. Sci Rep. 2019 Sep 24; 9(1):13765.

• Millan Catalan O, Campos-Parra AD, Vazquez-Romo R, Cantu de Leon D, Jacobo-Herrera N, Morales-Gonzalez F, Lopez-Camarillo C, Rodriguez-Dorantes M, Lopez-Urrutia E, Perez-Plasencia C. A Multi-Center Study of BRCA1 and BRCA2 Germline Mutations in Mexican-Mestizo Breast Cancer Families Reveals Mutations Unreported in Latin American Population. Cancers (Basel). 2019 Aug 26; 11(9):.

• Herrera-Sotero MY, Cruz-Hernandez CD, Oliart-Ros RM, Chavez-Servia JL, Guzman-Geronimo RI, Gonzalez-Covarrubias V, Cruz-Burgos M, Rodriguez-Dorantes M. Anthocyanins of Blue Corn and Tortilla Arrest Cell Cycle and Induce Apoptosis on Breast and Prostate Cancer Cells. Nutr Cancer. 2020; 72(5):768-777.

• Del Mar Diaz-Gonzalez S, Rodriguez-Aguilar ED, Meneses-Acosta A, Valadez-Graham V, Deas J, Gomez-Ceron C, Tavira-Montalvan CA, Arizmendi-Heras A, Ramirez-Bello J, Zurita-Ortega ME, Illades-Aguiar B, Leyva-Vazquez MA, Fernandez-Tilapa G, Bermudez-Morales VH, Madrid-Marina V, Rodriguez-Dorantes M, Perez-Plasencia C, Peralta-Zaragoza O. Transregulation of microRNA miR-21 promoter by AP-1 transcription factor in cervical cancer cells. Cancer Cell Int. 2019; 19:214.

• Llaguno-Munive M, Romero-Pina M, Serrano-Bello J, Medina LA, Uribe-Uribe N, Salazar AM, Rodriguez-Dorantes M, Garcia-Lopez P. Mifepristone Overcomes Tumor Resistance to Temozolomide Associated with DNA Damage Repair and Apoptosis in an Orthotopic Model of Glioblastoma. Cancers (Basel). 2018 Dec 22; 11(1):.

• Solorzano SR, Imaz-Rosshandler I, Camacho-Arroyo I, Garcia-Tobilla P, Morales-Montor G, Salazar P, Arena-Ortiz ML, Rodriguez-Dorantes M. GABA promotes gastrin-releasing peptide secretion in NE/NE-like cells: Contribution to prostate cancer progression. Sci Rep. 2018 Jul 6; 8(1):10272.

• Zamora-Sanchez CJ, Del Moral-Morales A, Hernandez-Vega AM, Hansberg-Pastor V, Salido-Guadarrama I, Rodriguez-Dorantes M, Camacho-Arroyo I. Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells. Int J Mol Sci. 2018 Mar 15; 19(3):.

• Valle-Gough R.E., Apodaca-Hernández JE., Rodriguez-Dorantes M., Arena-Ortiz ML.. Metatrancriptomic analysis from the Hepatopancreas of adult white leg shrimp (Litopenaeus vannamei). Am J Med Genet. 2018; 1:.

• Herrera-Sotero MY, Cruz-Hernandez CD, Trujillo-Carretero C, Rodriguez-Dorantes M, Garcia-Galindo HS, Chavez-Servia JL, Oliart-Ros RM, Guzman-Geronimo RI. Antioxidant and antiproliferative activity of blue corn and tortilla from native maize. Chem Cent J. 2017 Oct 30; 11(1):110.

• Jimenez-Ortega RF, Ramirez-Salazar EG, Parra-Torres AY, Munoz-Montero SA, Rangel-Escareno C, Salido-Guadarrama I, Rodriguez-Dorantes M, Quiterio M, Salmeron J, Velazquez-Cruz R. Identification of microRNAs in human circulating monocytes of postmenopausal osteoporotic Mexican-Mestizo women: A pilot study. Exp Ther Med. 2017 Dec; 14(6):5464-5472.

• Zamora-Sanchez CJ, Hansberg-Pastor V, Salido-Guadarrama I, Rodriguez-Dorantes M, Camacho-Arroyo I. Allopregnanolone promotes proliferation and differential gene expression in human glioblastoma cells. Steroids. 2017 Jan 22; 119:36-42.

• Rivera-Toledo E, Salido-Guadarrama I, Rodriguez-Dorantes M, Torres-Gonzalez L, Santiago-Olivares C, Gomez B. Conditioned medium from persistently RSV-infected macrophages alters transcriptional profile and inflammatory response of non-infected macrophages. Virus Res. 2017 Jan 06; :.

• Srivastava AK, Wang Y, Huang R, Skinner C, Thompson T, Pollard L, Wood T, Luo F, Stevenson R, Polimanti R, Gelernter J, Lin X, Lim IY, Wu Y, Teh AL, Chen L, Aris IM, Soh SE, Tint MT, MacIsaac JL, Yap F, Kwek K, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Holbrook JD, Lee YS, Gluckman PD, Karnani N; GUSTO study group, Kapoor A, Lee D, Chakravarti A, Maercker C, Graf F, Boutros M, Stamoulis G, Santoni F, Makrythanasis P, Letourneau A, Guipponi M, Panousis N, Garieri M, Ribaux P, Falconnet E, Borel C, Antonarakis SE, Kumar S, Curran J, Blangero J, Chatterjee S, Akiyama J, Auer D, Berrios C, Pennacchio L, Donti TR, Cappuccio G, Miller M, Atwal P, Kennedy A, Cardon A, Bacino C, Emrick L, Hertecant J, Baumer F, Porter B, Bainbridge M, Bonnen P, Graham B, Sutton R, Sun Q, Elsea S, Hu Z, Wang P, Zhu Y, Zhao J, Xiong M, Bennett DA, Hidalgo-Miranda A, Romero-Cordoba S, Rodriguez-Cuevas S, Rebollar- Vega R, Tagliabue E, Iorio M, D’Ippolito E, Baroni S, Kaczkowski B, Tanaka Y, Kawaji H, Sandelin A, Andersson R, Itoh M, Lassmann T; The FANTOM5 Consortium, Hayashizaki Y, Carninci P, Forrest ARR, Semple CA, Rosenthal EA, Shirts B, Amendola L, Gallego C, Horike-Pyne M, Burt A, Robertson P, Beyers P, Nefcy C, Veenstra D, Hisama F, Bennett R, Dorschner M, Nickerson D, Smith J, Patterson K, Crosslin D, Nassir R, Zubair N, Harrison T, Peters U, Jarvik G; NHLBI GO Exome Sequencing Project, Menghi F, Inaki K, Woo X, Kumar P, Grzeda K, Malhotra A, Kim H, Ucar D, Shreckengast P, Karuturi K, Keck J, Chuang J, Liu ET, Ji B, Tyler A, Ananda G, Carter G, Nikbakht H, Montagne M, Zeinieh M, Harutyunyan A, Mcconechy M, Jabado N, Lavigne P, Majewski J, Goldstein JB, Overman M, Varadhachary G, Shroff R, Wolff R, Javle M, Futreal A, Fogelman D, Bravo L, Fajardo W, Gomez H, Castaneda C, Rolfo C, Pinto JA, Akdemir KC, Chin L, Futreal A; ICGC PCAWG Structural Alterations Group, Patterson S, Statz C, Mockus S, Nikolaev SN, Bonilla XI, Parmentier L, King B, Bezrukov F, Kaya G, Zoete V, Seplyarskiy V, Sharpe H, McKee T, Popadin K, Basset-Seguin N, Chaabene RB, Andrianova M, Verdan C, Grosdemange K, Sumara O, Eilers M, Aifantis I, Michielin O, de Sauvage F, Antonarakis S, Likhitrattanapisal S, Lincoln S, Kurian A, Desmond A, Yang S, Kobayashi Y, Ford J, Ellisen L, Peters TL, Alvarez KR, Hollingsworth EF, Lopez-Terrada DH, Hastie A, Dzakula Z, Pang AW, Lam ET, Anantharaman T, Saghbini M, Cao H; BioNano Genomics, Gonzaga-Jauregui C, Ma L, King A, Rosenzweig EB, Krishnan U, Reid JG, Overton JD, Dewey F, Chung WK, Small K, DeLuca A, Cremers F, Lewis RA, Puech V, Bakall B, Silva-Garcia R, Rohrschneider K, Leys M, Shaya FS, Stone E, Sobreira NL, Schiettecatte F, Ling H, Pugh E, Witmer D, Hetrick K, Zhang P, Doheny K, Valle D, Hamosh A, Jhangiani SN, Akdemir ZC, Bainbridge MN, Charng W, Wiszniewski W, Gambin T, Karaca E, Bayram Y, Eldomery MK, Posey J, Doddapaneni H, Hu J, Sutton VR, Muzny DM, Boerwinkle EA, Lupski JR, Gibbs RA, Shekar S, Salerno W, English A, Mangubat A, Bruestle J, Thorogood A, Knoppers BM; Global Alliance for Genomics and Health - Regulatory and Ethics Working Group, Takahashi H, Nitta KR, Kozhuharova A, Suzuki AM, Sharma H, Cotella D, Santoro C, Zucchelli S, Gustincich S, Mulvihill JJ, Baynam G, Gahl W, Groft SC, Kosaki K, Lasko P, Melegh B, Taruscio D, Ghosh R, Plon S, Scherer S, Qin X, Sanghvi R, Walker K, Chiang T, Muzny D, Wang L, Black J, Boerwinkle E, Weinshilboum R, Gibbs R, Karpinets T, Calderone T, Wani K, Yu X, Creasy C, Haymaker C, Forget M, Nanda V, Roszik J, Wargo J, Haydu L, Song X, Lazar A, Gershenwald J, Davies M, Bernatchez C, Zhang J, Woodman S, Chesler EJ, Reynolds T, Bubier JA, Phillips C, Langston MA, Baker EJ, Lin N, Amos C, Calhoun V, Dobretsberger O, Egger M, Leimgruber F, Sadedin S, Oshlack A; Melbourne Genomics Health Alliance, Antonio VAA, Ono N; Clark Kendrick C. Go, Ahmed Z, Bolisetty M, Zeeshan S, Anguiano E, Sarkar A, Nandineni MR, Zeng C, Shao J, Cao H, Liang T, Pham K, Chee-Wei Y, Dongsheng L, Lai-Ping W, Lian D, Hee ROT, Yunus Y, Aghakhanian F, Mokhtar SS, Lok-Yung CV, Bhak J, Phipps M, Shuhua X, Yik-Ying T, Kumar V, Boon-Peng H, Campbell I, Young MA, James P; Lifepool, Rain M, Mohammad G, Kukreti R, Pasha Q, Akilzhanova AR, Guelly C, Abilova Z, Rakhimova S, Akhmetova A, Kairov U, Trajanoski S, Zhumadilov Z, Bekbossynova M, Schumacher C, Sandhu S, Harkins T, Makarov V, Glenn R, Momin Z, Dilrukshi B, Chao H, Meng Q, Gudenkauf B, Kshitij R, Jayaseelan J, Nessner C, Lee S, Blankenberg K, Lewis L, Han Y, Dinh H, Jireh S, Buhay C, Liu X, Wang Q, Ding Y, Veeraraghavan N, Yang Y, Beaudet AL, Eng CM, Worley KCC, Liu Y, Hughes DST, Murali SC, Harris RA, English AC, Hampton OA, Larsen P, Beck C, Wang M, Kovar CL, Salerno WJ, Yoder A, Richards S, Rogers J, Raveenedran M, Xue C, Dahdouli M, Cox L, Fan G, Ferguson B, Hovarth J, Johnson Z, Kanthaswamy S, Kubisch M, Platt M, Smith D, Vallender E, Wiseman R, Below J, Yu F, Lin J, Zhang Y, Ouyang Z, Moore A, Wang Z, Hofmann J, Purdue M, Stolzenberg-Solomon R, Weinstein S, Albanes D, Liu CS, Cheng WL, Lin TT, Lan Q, Rothman N, Berndt S, Chen ES, Bahrami H, Khoshzaban A, Keshal SH, Alharbi KKR, Zhalbinova M, Akilzhanova A, Bekbosynova M, Myrzakhmetova S, Matar M, Mili N, Molinari R, Ma Y, Guerrier S, Elhawary N, Tayeb M, Bogari N, Qotb N, McClymont SA, Hook PW, Goff LA, McCallion A, Kong Y, Charette JR, Hicks WL, Naggert JK, Zhao L, Nishina PM, Edrees BM, Athar M, Al- Allaf FA, Taher MM, Khan W, Bouazzaoui A, Harbi NA, Safar R, Al-Edressi H, Anazi A, Altayeb N, Ahmed MA, Alansary K, Abduljaleel Z, Kratz A, Beguin P, Poulain S, Kaneko M, Takahiko C, Matsunaga A, Kato S, Bertin N, Lassmann T, Vigot R, Plessy C, Launey T, Graur D, Friis-Nielsen J, Izarzugaza JM, Brunak S, Chakraborty A, Basak J, Mukhopadhyay A, Soibam BS, Das D, Biswas N, Das S, Sarkar S, Maitra A, Panda C, Majumder P, Morsy H, Gaballah A, Samir M, Shamseya M, Mahrous H, Ghazal A, Arafat W, Hashish M, Gruber JJ, Jaeger N, Snyder M, Patel K, Bowman S, Davis T, Kraushaar D, Emerman A, Russello S, Henig N, Hendrickson C, Zhang K, Rodriguez-Dorantes M, Cruz-Hernandez CD, Garcia-Tobilla CDP, Solorzano-Rosales S, Jäger N, Chen J, Haile R, Hitchins M, Brooks JD, Jiménez-Morales S, Ramírez M, Nuñez J, Bekker V, Leal Y, Jiménez E, Medina A, Hidalgo A, Mejía J, Halytskiy V, Naggert J, Collin GB, DeMauro K, Hanusek R, Belhassa K, Belhassan K, Bouguenouch L, Samri I, Sayel H, moufid FZ, El Bouchikhi I, Trhanint S, Hamdaoui H, Elotmani I, Khtiri I, Kettani O, Quibibo L, Ahagoud M, Abbassi M, Ouldim K, Marusin AV, Kornetov AN, Swarovskaya M, Vagaiceva K, Stepanov V, De La Paz EMC, Sy R, Nevado J, Reganit P, Santos L, Magno JD, Punzalan FE, Ona D, Llanes E, Santos-Cortes RL, Tiongco R, Aherrera J, Abrahan L, Pagauitan-Alan P; The Philippine Cardiogenomics Study Group, Morelli KH, Domire JS, Pyne N, Harper S, Burgess R, Gari MA, Dallol A, Alsehli H, Gari A, Gari M, Abuzenadah A, Thomas M, Sukhai M, Garg S, Misyura M, Zhang T, Schuh A, Stockley T, Kamel-Reid S, Sherry S, Xiao C, Slotta D, Rodarmer K, Feolo M, Kimelman M, Godynskiy G, O’Sullivan C, Yaschenko E, Rangel-Escareño C, Rueda-Zarate H, Tayubi IA, Mohammed R; on behalf of 1, Ahmed I, Ahmed T, Seth S, Amin S, Mao X, Sun H, Verhaak RG, Whiite SJ, Farek J, Kahn Z, Kasukawa T, Lizio M, Harshbarger J, Hisashi S, Severin J, Imad A, Sahin S, Freeman TC, Baillie K, Kawaji H; The FANTOM Consortium, Shekar SN, Salem AH, Ali M, Ibrahim A, Ibrahim M, Barrera HA, Garza L, Torres JA, Barajas V, Ulloa-Aguirre A, Kershenobich D, Mortaji S, Guizar P, Loera E, Moreno K, De León A, Monsiváis D, Gómez J, Cardiel R, Fernandez-Lopez JC, Bonifaz-Peña V, Contreras AV, Polfus L; CHARGE and NHLBI Exome Sequence Project Working Groups, Wang X, Philip V, Abuzenadah AA, Turki R, Uyar A, Kaygun A, Zaman S, Marquez E, George J, Hendrickson CL, Starr DB, Baird M, Kirkpatrick B, Sheets K, Nitsche R, Prieto-Lafuente L, Landrum M, Lee J, Rubinstein W, Maglott D, Thavanati PKR, de Dios AE, Hernandez REN, Aldrate MEA, Mejia MRR, Kanala KRR, Al-Allaf FA, Shahzad N, Huber E, Dan A, Herr W, Sprotte G, Köstler J, Hiergeist A, Gessner A, Andreesen R, Holler E, Al-Allaf F, Alashwal A, Taher M, Abalkhail H, Al-Allaf A, Bamardadh R, Filiptsova O, Kobets M, Kobets Y, Burlaka I, Timoshyna I, Kobets MN, Mohiuddin MT, Zainularifeen A, Mohammed A, Owaidah T. Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016. Hum Genomics. 2016 May 26; 10 Suppl 1(Suppl 1):12.

• Peralta-Zaragoza O, Deas J, Meneses-Acosta A, De la O-Gomez F, Fernandez-Tilapa G, Gomez-Ceron C, Benitez-Boijseauneau O, Burguete-Garcia A, Torres-Poveda K, Bermudez-Morales VH, Madrid-Marina V, Rodriguez-Dorantes M, Hidalgo-Miranda A, Perez-Plasencia C. Relevance of miR-21 in regulation of tumor suppressor gene PTEN in human cervical cancer cells. BMC Cancer. 2016; 16(1):215.

• Diaz-Gonzalez SD, Deas J, Benitez-Boijseauneau O, Gomez-Ceron C, Bermudez-Morales VH, Rodriguez-Dorantes M, Perez-Plasencia C, Peralta-Zaragoza O. Utility of MicroRNAs and siRNAs in Cervical Carcinogenesis. Biomed Res Int. 2015; 2015:374924.

• Peralta-Zaragoza O, De-la-O-Gomez F, Deas J, Fernandez-Tilapa G, Fierros-Zarate Gdel S, Gomez-Ceron C, Burguete-Garcia A, Torres-Poveda K, Bermudez-Morales VH, Rodriguez-Dorantes M, Perez-Plasencia C, Madrid-Marina V. Selective Silencing of Gene Target Expression By siRNA Expression Plasmids in Human Cervical Cancer Cells.. Methods Mol Biol. 2015; 1249:153-71.

• Romero-Cordoba SL, Salido-Guadarrama I, Rodriguez-Dorantes M, Hidalgo-Miranda A. miRNA biogenesis: biological impact in the development of cancer.. Cancer Biol Ther. 2014 Aug 21; 15(11):1444-55.

• Salido-Guadarrama I, Romero-Cordoba S, Peralta-Zaragoza O, Hidalgo-Miranda A, Rodriguez-Dorantes M. MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer. Onco Targets Ther. 2014; 7:1327-38.

• Camacho-Arroyo I, Hansberg-Pastor V, Rodriguez-Dorantes M. DNA methylation analysis of steroid hormone receptor genes.. Methods Mol Biol. 2014; 1165:89-98.

• Rodriguez-Dorantes M, Salido-Guadarrama AI, Garcia-Tobilla P. Prostate cancer detection using a noninvasive method for quantifying miRNAs.. Methods Mol Biol. 2014; 1165:81-7.

• Mendoza-Garces L, Rodriguez-Dorantes M, Alvarez-Delgado C, Vazquez-Martinez ER, Garcia-Tobilla P, Cerbon MA. Differential DNA methylation pattern in the A and B promoters of the progesterone receptor is associated with differential mRNA expression in the female rat hypothalamus during proestrus. Brain Res. 2013 Aug 27; 1535:71-7.

• Hansberg-Pastor V, Gonzalez-Arenas A, Pena-Ortiz MA, Garcia-Gomez E, Rodriguez-Dorantes M, Camacho-Arroyo I. The role of DNA methylation and histone acetylation in the regulation of progesterone receptor isoforms expression in human astrocytoma cell lines. Steroids. 2013 Mar 5; 78(5):500-507.

• Saavedra-Briones Dorian V, Rodríguez-Dorantes Mauricio, 2 Morales-Montor Jorge G, Miranda-Ortiz Haydee, Salido-Guadarrama Ivan, 2 Merayo-Chalico Claudio E, 1 Hernández-Castellanos Víctor A, 1 Sánchez-Turati Gustavo J, 1 Ahumada-Tamayo Samuel, 1 Fernández-Noyola Gerardo, 1 Martínez José A, 1 García-Edgar Víctor N, 3 Cantellano-Orozco Mauricio, 1 Pacheco-Gahbler Carlos, 1 Calderón-Ferro Francisco1. Initial experience in prostate cancer detection in mexican patients at the hospital manuel gea gonzáles usin a low- cost pca3 test. Rev Mex Urol. 2010; 70:328-335.

• Balam-Ortiz E, Esquivel-Villarreal A, Huerta-Hernandez D, Fernandez-Lopez JC, Alfaro-Ruiz L, Munoz-Monroy O, Gutierrez R, Figueroa-Genis E, Carrillo K, Elizalde A, Hidalgo A, Rodriguez M, Urushihara M, Kobori H, Jimenez-Sanchez G. Hypercontrols in genotype-phenotype analysis reveal ancestral haplotypes associated with essential hypertension. Hypertension. 2012 Apr; 59(4):847-53.

• Baca-Lopez K, Correa-Rodriguez Md, Flores-Espinosa R, Garcia-Herrera R, Hernandez-Armenta Ci, Hidalgo-Miranda A, Huerta-Verde Aj, Imaz-Rosshandler I, Martinez-Rubio Av, Medina-Escareno A, Mendoza-Smith R, Rodriguez-Dorantes M, Salido-Guadarrama I, Hernandez-Lemus E, Rangel-Escareno C. A Three-State Model For Multidimensional Genomic Data Integration. CAMDA. 2011; :0-0.

• Rodriguez-Dorantes M, Lopez-Griego L, Zarazua-Cruz CM, Morales-Montor J. Altered expression of cytokines and sex steroid receptors in the reproductive tract of cysticercotic male mice. Parasite Immunology. 2010 Feb; 32(2):91-100.

• Hernandez-Hernandez OT, Rodriguez-Dorantes M, Gonzalez-Arenas A, Camacho-Arroyo I. Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human astrocytoma cell lines. Endocrine. 2010 Feb; 37(1):194-200.

• Arteaga-Silva M, Vargas-Villavicencio JA, Vigueras-Villasenor RM, Rodriguez-Dorantes M, Morales-Montor J. Taenia crassiceps infection disrupts estrous cycle and reproductive behavior in BALB/c female mice. Acta Trop. 2009 Feb; 109(2):141-5.

• Estrada-Villasenor E, Morales-Montor J, Rodriguez-Dorantes M, Ramos-Martinez E, Nequiz-Avendano M, Ostoa-Saloma P. IL-6 KO mice develop experimental amoebic liver infection with eosinophilia. J Parasitol. 2007 Dec; 93(6):1424-8.

• Rodriguez-Dorantes M, Cerbon MA, Larralde C, Morales-Montor J. Modified progesterone receptor expression in the hypothalamus of cysticercotic male mice. Acta Trop. 2007 Aug; 103(2):123-32.

• Arteaga-Silva M, Rodriguez-Dorantes M, Baig S, Morales-Montor J. Effects of castration and hormone replacement on male sexual behavior and pattern of expression in the brain of sex-steroid receptors in BALB/c AnN mice. Comp Biochem Physiol A Mol Integr Physiol. 2007 Jul; 147(3):607-15.

• Aguilar-Diaz H, Bobes RJ, Carrero JC, Camacho-Carranza R, Cervantes C, Cevallos MA, Davila G, Rodriguez-Dorantes M, Escobedo G, Fernandez JL, Fragoso G, Gaytan P, Garciarubio A, Gonzalez VM, Gonzalez L, Jose MV, Jimenez L, Laclette JP, Landa A, Larralde C, Morales-Montor J, Morett E, Ostoa-Saloma P, Sciutto E, Santamaria RI, Soberon X, de la Torre P, Valdes V, Yanez J. The genome project of Taenia solium. Parasitol Int. 2006; 55 Suppl:S127-30.

• Romo-Gonzalez T, Morales-Montor J, Rodriguez-Dorantes M, Vargas-Madrazo E. Novel substitution polymorphisms of human immunoglobulin VH genes in Mexicans. Hum Immunol. 2005 Jun; 66(6):732-40.

• Morales-Montor J, Escobedo G, Rodriguez-Dorantes M, Tellez-Ascencio N, Cerbon MA, Larralde C. Differential expression of AP-1 transcription factor genes c-fos and c-jun in the helminth parasites Taenia crassiceps and Taenia solium. Parasitology. 2004 Aug; 129(Pt 2):233-43.

• Morales-Montor J, Arrieta I, Del Castillo LI, Rodriguez-Dorantes M, Cerbon MA, Larralde C. Remote sensing of intraperitoneal parasitism by the host's brain: regional changes of c-fos gene expression in the brain of feminized cysticercotic male mice. Parasitology. 2004 Mar; 128(Pt 3):343-51.

• Garcia-Lopez P, Rodriguez-Dorantes M, Perez-Cardenas E, Cerbon M, Mohar-Betancourt A. Synergistic effects of ICI 182,780 on the cytotoxicity of cisplatin in cervical carcinoma cell lines. Cancer Chemother Pharmacol. 2004 Jun; 53(6):533-40.

• Rodriguez-Dorantes M, Tellez-Ascencio N, Cerbon MA, Lopez M, Cervantes A. Metilacion del ADN: un fenomeno epigenetico de importancia medic. Rev Invest Clin. 2004 Jan-Feb; 56(1):56-71.

• Rodriguez-Dorantes M, Lizano-Soberon M, Camacho-Arroyo I, Calzada-Leon R, Morimoto S, Tellez-Ascencio N, Cerbon MA. Evidence that steroid 5alpha-reductase isozyme genes are differentially methylated in human lymphocytes. J Steroid Biochem Mol Biol. 2002 Mar; 80(3):323-30.

• Fernandez-Mejia C, Vega-Allende J, Rojas-Ochoa A, Rodriguez-Dorantes M, Romero-Navarro G, Matschinsky FM, Wang J, German MS. Cyclic adenosine 3',5'-monophosphate increases pancreatic glucokinase activity and gene expression. Endocrinology. 2001 Apr; 142(4):1448-52.

• Morales-Montor J, Gamboa-Dominguez A, Rodriguez-Dorantes M, Cerbon MA. Tissue damage in the male murine reproductive system during experimental Taenia crassiceps cysticercosis. J Parasitol. 1999 Oct; 85(5):887-90.

• Morales-Montor J, Rodriguez-Dorantes M, Cerbon MA. Modified expression of steroid 5 alpha-reductase as well as aromatase, but not cholesterol side-chain cleavage enzyme, in the reproductive system of male mice during (Taenia crassiceps) cysticercosis. Parasitol Res. 1999 May; 85(5):393-8.

• Morales-Montor J, Rodriguez-Dorantes M, Mendoza-Rodriguez CA, Camacho-Arroyo I, Cerbon MA. Differential expression of the estrogen-regulated proto-oncogenes c-fos, c-jun, and bcl-2 and of the tumor-suppressor p53 gene in the male mouse chronically infected with Taenia crassiceps cysticerci. Parasitol Res. 1998 Aug; 84(8):616-22.

• Mauricio Rodríguez-Dorantes, Juan Pablo Reyes-Grajeda Alfredo Hidalgo-Miranda and Gerardo Jiménez-Sánchez. THE ROLE OF ANDROGENS IN PROSTATE CANCER. IGNACIO CAMACHO-ARROYO. Advances in Selected Topics in Endocrinology, 2009. RESEARCH SIGNPOST; 2009. 18
• Camacho Arroyo I and Rodriguez-Dorantes M. TRANSCRIPTIONAL ACTIVITY REGULATED BY PROGESTERONE RECEPTOR ISOFORMS. JOSEPH BRAVO PATRICIA. MOLECULAR ENDOCRINOLOGY. RESEARCH SIGN POST; 2006. 13
• A.MENDOZA RODRIGUEZ CA., ARRIETA CRUZ I., RODRIGUEZ DORANTES M. CAMACHO ARROYO I, CERBON MA.. REGULACION DE LA TRANSCRIPCION POR HORMONAS ESTEROIDES SEXUALES. MENSAJE BIOQUIMICO 2001 VOL XXV DEPARTAMENTO DE BIOQUIMICA,FACULTAD DE MEDICINA. MEXICO.. MA JUAREZ OROPEZA JP PARDO VAZQUEZ, IP DEL ARENAL MENA. MENSAJE BIOQUIMICO 2001 VOL XXV DEPARTAMENTO DE BIOQUIMICA,FACULTAD DE MEDICINA. MEXICO.. DEPARTAMENTO DE BIOQUIMICA; 2001. 18

Doctorado

• INTRODUCCION A LA MEDICINA GENOMICA, UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO / COORDINACION DE INVESTIGACION CIENTIFICA / FACULTAD DE MEDICINA / DIVISION DE ESTUDIOS DE POSTGRADO

Especialidad

• IDENTIFICACION DE MICRORGANISMOS POR METODOS DE BIOLOGIA MOLECULAR, UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO / COORDINACION DE INVESTIGACION CIENTIFICA / FACULTAD DE QUÍMICA / DEPTO. DE BIOLOGIA

Licenciatura

• BIOLOGIA CELULAR, UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO / COORDINACION DE INVESTIGACION CIENTIFICA / FACULTAD DE QUÍMICA / DEPTO. DE BIOLOGIA
• INGENIERIA GENETICA, INSTITUTO TECNOLÓGICO Y DE ESTUDIOS SUPERIORES DE MONTERREY / CAMPUS CIUDAD DE MÉXICO / DIVISION DE CIENCIAS DE LA SALUD / Ingeniero en Biotecnología
• BIOLOGIA CELULAR, UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO / COORDINACION DE INVESTIGACION CIENTIFICA / FACULTAD DE QUÍMICA / DEPTO. DE BIOLOGIA

Maestria

• APLICACIONES GENOMICAS EN MEDICINA INTERNA, UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO / COORDINACION DE INVESTIGACION CIENTIFICA / FACULTAD DE MEDICINA / DIVISION DE ESTUDIOS DE POSTGRADO

Tesista de Doctorado

• Jenie Marian Cruz Burgos
• Miguel Morales Pacheco

Tesista de Maestría

• Miguel Valenzuela Mayén

Tesista de Licenciatura

• Manuel Ehecatl Bahena Salgado

Servicio Social

• Ángel Mauricio González Alatriste
• Juan Manuel Martínez Magallán
• Stephanie Carolina Perales Angeles

Estancia Voluntaria

• Alberto Losada García
• Alicia Cañas Linares
• Carlos Ponce Vivas
• Daniela López Méndez
• Imelda del Carmen González Ramírez
• Luz Andrea López Barraza

Práctica Profesional

• José Manuel Zavala Arteaga

• Posdoctorado, Universidad Nacional Autonoma De Mexico / Coordinacion De Investigacion Cientifica / Instituto De Investigaciones Biomédicas / Inmunologia (2007-12-01)
• Doctorado en ciencias biomedicas, UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (2005-01-01)

• Español

En curso

• Diseño de una Quimera Aptámero-siRNA como modelo para el silenciamiento del gen TMPSS2-ERG en cáncer de próstata
• Identificación de MiRNA’S Exosomales como posibles herramientas de diagnóstico y pronóstico de metástasis en cáncer de Próstata.
• Papel de los microARNs en hiperplasia prostática benigna: firma molecular en glándulas prostáticas de diferente volúmen.

Terminados

• Análisis funcional de la vía de activación Androgénica como un factor de agresividad en tumores de mama triples negativos.
• EFECTO DE OMEGA 3 SOBRE LOS PATRONES DE METILACIÓN DEL DNA DE GENES EN UN MODELO CON SÍNDROME METABÓLICO INDUCIDO POR LA DIETA
• El papel de la Progesterona en el crecimiento de tumores cerebrales
• Especificidad de la Determinación de PCA3 en Orina para la detección de cáncer de próstata en pacientes mexicanos en el Hospital General "Dr Manuel Gea González".
• Modelo basado en redes Bayesianas dinámicas para inferir la regulación de microRNAs y mensajero en respuesta a andrógenos en cáncer
• Participación de los miRNAs como posibles marcadores moleculares de diagnóstico temprano en cáncer de Próstata
• Participación de SFRP1 en estroma y su efecto parácrino en células epiteliales de cáncer de próstata
• Perfil de expresión diferencial de genes durante la transdiferenciación al fenotipo NE a partir de células de Cáncer de Próstata

Doctorado

• Consuelo Del Pilar Garcia Tobi. Cambios en los patrones de metilación de los genes de la familia SFRP y su posible implicación en el desarrollo del cáncer de próstata. UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO.
• Susana Del Rocio Solorzano Ros. Participación del sistema GABAergico en la diferenciación neuroendocrina del cáncer de próstata.. UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO.
• Iván Sálido Guadarrama. Caracterización de MicroRnas diferencialmente expresados en la enfermedad prostatica benigna y el cáncer de próstata como un nuevo mecanismo hacia la independencia de andrógenos. UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO.

• INVESTIGADOR POSDOCTORAL, Universidad Nacional Autonoma De Mexico / Coordinacion De Investigacion Cientifica / Instituto De Investigaciones Biomédicas / Inmunologia (2007-02-28)
• ESTUDIANTE DE DOCTORADO, UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (2002-08-01)