Sitio del Instituto Nacional de Medicina Genómica

Del Bosque-Plata L, Hernandez-Cortes EP, Gragnoli C. The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes. J Cell Physiol. 2021 Oct 6; :.

Vergara-Geronimo CA, Leon Del Rio A, Rodriguez-Dorantes M, Ostrosky-Wegman P, Salazar AM. Arsenic-protein interactions as a mechanism of arsenic toxicity. Toxicol Appl Pharmacol. 2021 Oct 4; 431:115738.

Moran-Ramos S, Macias-Kauffer L, Lopez-Contreras BE, Villamil-Ramirez H, Ocampo-Medina E, Leon-Mimila P, Del Rio-Navarro BE, Granados-Portillo O, Ibarra-Gonzalez I, Vela-Amieva M, Tovar AR, Torres N, Gomez-Perez FJ, Aguilar-Salinas C, Canizales-Quinteros S. A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents. Mol Med. 2021 Sep 15; 27(1):108.

Gomez-Verjan JC, Esparza-Aguilar M, Martin-Martin V, Salazar-Perez C, Cadena-Trejo C, Gutierrez-Robledo LM, Martinez-Magana JJ, Nicolini H, Arroyo P. Years of Schooling Could Reduce Epigenetic Aging: A Study of a Mexican Cohort. Genes (Basel). 2021 Sep 13; 12(9):.

Ramirez-Salazar EG, Gayosso-Gomez LV, Baez-Saldana R, Falfan-Valencia R, Perez-Padilla R, Higuera-Iglesias AL, Vazquez-Manriquez ME, Ortiz-Quintero B. Cigarette Smoking Alters the Expression of Circulating microRNAs and Its Potential Diagnostic Value in Female Lung Cancer Patients. Biology (Basel). 2021 Aug 18; 10(8):.

Morales-Rivera MI, Alemon-Medina R, Martinez-Hernandez A, Gomez-Garduno J, Mirzaeicheshmeh E, Altamirano-Bustamante NF, Ilizaliturri-Flores I, Mendoza-Caamal EC, Perez-Guille MG, Garcia-Alvarez R, Contreras-Cubas C, Centeno-Cruz F, Revilla-Monsalve C, Garcia-Ortiz H, Barajas-Olmos F, Orozco L. The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate. Biomed Pharmacother. 2021 Oct; 142:112009.

Gonzalez-Salazar LE, Granados-Portillo O, Medina-Vera I, Pichardo-Ontiveros E, Vigil-Martinez A, Guizar-Heredia R, Palacios-Gonzalez B, Arteaga-Sanchez L, Hernandez-Gomez KG, Avila-Nava A, Serralde-Zuniga AE, Flores-Lopez A, Noriega LG, Torres N, Olin-Sandoval V, Vazquez-Manjarrez N, Dominguez-Velazquez ZN, Reyes-Garcia JG, Tovar AR, Guevara-Cruz M. Effect of the BCAT2 polymorphism (rs11548193) on plasma branched-chain amino acid concentrations after dietary intervention in subjects with obesity and insulin resistance. Br J Nutr. 2021 Aug 3; :1-30.

Vargas-Morales JM, Guizar-Heredia R, Mendez-Garcia AL, Palacios-Gonzalez B, Schcolnik-Cabrera A, Granados O, Lopez-Barradas AM, Vazquez-Manjarrez N, Medina-Vera I, Aguilar-Lopez M, Tovar-Palacio C, Ordaz-Nava G, Rocha-Viggiano AK, Medina-Cerda E, Torres N, Ordovas JM, Tovar AR, Guevara-Cruz M, Noriega LG. Association of BCAT2 and BCKDH polymorphisms with clinical, anthropometric and biochemical parameters in young adults. Nutr Metab Cardiovasc Dis. 2021 Oct 28; 31(11):3210-3218.

Bikel S, Lopez-Leal G, Cornejo-Granados F, Gallardo-Becerra L, Garcia-Lopez R, Sanchez F, Equihua-Medina E, Ochoa-Romo JP, Lopez-Contreras BE, Canizales-Quinteros S, Hernandez-Reyna A, Mendoza-Vargas A, Ochoa-Leyva A. Gut dsDNA virome shows diversity and richness alterations associated with childhood obesity and metabolic syndrome. iScience. 2021 Aug 20; 24(8):102900.

Ballinas-Verdugo MA, Jimenez-Ortega RF, Martinez-Martinez E, Rivas N, Contreras-Lopez EA, Carbo R, Sanchez F, Bojalil R, Marquez-Velasco R, Sanchez-Munoz F, Alejandre-Aguilar R. Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease. Biol Res. 2021 Jul 21; 54(1):21.

Hernandez-Lopez R, Hermosillo L, Leon-Maldonado L, Velazquez-Cruz R, Torres-Ibarra L, Lazcano-Ponce E, Lorincz A, Wheeler CM, Bosch FX, Cuzick J, Rivera-Paredez B, Nedjai B, Salmeron J. Performance of an affordable urine self-sampling method for human papillomavirus detection in Mexican women. PLoS One. 2021; 16(7):e0254946.

Rosas-Madrigal S, Villarreal-Molina MT, Flores-Rivera J, Rivas-Alonso V, Macias-Kauffer LR, Ordonez G, Chima-Galan MDC, Acuna-Alonzo V, Macin-Perez G, Barquera R, Granados J, Valle-Rios R, Corona T, Carnevale A, Romero-Hidalgo S. Interaction of HLA Class II rs9272219 and TMPO rs17028450 (Arg690Cys) Variants Affects Neuromyelitis Optica Spectrum Disorder Susceptibility in an Admixed Mexican Population. Front Genet. 2021; 12:647343.

Perez-Amado CJ, Bazan-Cordoba A, Hidalgo-Miranda A, Jimenez-Morales S. Mitochondrial Heteroplasmy Shifting as a Potential Biomarker of Cancer Progression. Int J Mol Sci. 2021 Jul 9; 22(14):.

Leon-Mimila P, Villamil-Ramirez H, Macias-Kauffer LR, Jacobo-Albavera L, Lopez-Contreras BE, Posadas-Sanchez R, Posadas-Romero C, Romero-Hidalgo S, Moran-Ramos S, Dominguez-Perez M, Olivares-Arevalo M, Lopez-Montoya P, Nieto-Guerra R, Acuna-Alonzo V, Macin-Perez G, Barquera-Lozano R, Del-Rio-Navarro BE, Gonzalez-Gonzalez I, Campos-Perez F, Gomez-Perez F, Valdes VJ, Sampieri A, Reyes-Garcia JG, Carrasco-Portugal MDC, Flores-Murrieta FJ, Aguilar-Salinas CA, Vargas-Alarcon G, Shih D, Meikle PJ, Calkin AC, Drew BG, Vaca L, Lusis AJ, Huertas-Vazquez A, Villarreal-Molina T, Canizales-Quinteros S. Genome-Wide Association Study Identifies a Functional SIDT2 Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2021 Jul 8; :ATVBAHA120315391.

Allouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, McConnell AM, Kato S, Fan S, Kawakami A, Suita Y, Wakamatsu K, Igras V, Zhang J, Navarro PP, Lugo CM, Noonan HR, Christie KA, Itin K, Mujahid N, Lo JA, Won CH, Evans CL, Weng QY, Wang H, Osseiran S, Lovas A, Nemeth I, Cozzio A, Navarini AA, Hsiao JJ, Nguyen N, Kemeny LV, Iliopoulos O, Berking C, Ruzicka T, Gonzalez-Jose R, Bortolini MC, Canizales-Quinteros S, Acuna-Alonso V, Gallo C, Poletti G, Bedoya G, Rothhammer F, Ito S, Schiaffino MV, Chao LH, Kleinstiver BP, Tishkoff S, Zon LI, Nijsten T, Ruiz-Linares A, Fisher DE, Roider E. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 Aug 5; 184(16):4268-4283.e20.

Delgadillo-Velazquez JA, Nambo-Venegas R, Patino N, Meraz-Cruz N, Razo-Azamar M, Guevara-Cruz M, Fonseca M, Pale Montero LE, Ibarra-Gonzalez I, Vela-Amieva M, Vadillo-Ortega F, Palacios-Gonzalez B. Metabolic flexibility during normal pregnancy allows appropriate adaptation during gestation independently of BMI. Clin Nutr ESPEN. 2021 Aug; 44:254-262.

Abreu Y Abreu AT, Milke-Garcia MP, Arguello-Arevalo GA, Calderon-de la Barca AM, Carmona-Sanchez RI, Consuelo-Sanchez A, Coss-Adame E, Garcia-Cedillo MF, Hernandez-Rosiles V, Icaza-Chavez ME, Martinez-Medina JN, Moran-Ramos S, Ochoa-Ortiz E, Reyes-Apodaca M, Rivera-Flores RL, Zamarripa-Dorsey F, Zarate-Mondragon F, Vazquez-Frias R. Dietary fiber and the microbiota: A narrative review by a group of experts from the Asociacion Mexicana de Gastroenterologia. Rev Gastroenterol Mex (Engl Ed). 2021 Jul-Sep; 86(3):287-304.

Melendez-Zajgla J, Maldonado V. The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal Adenocarcinoma. Int J Mol Sci. 2021 Jun 15; 22(12):.

de Anda-Jauregui G, Espinal-Enriquez J, Hernandez-Lemus E. Highly connected, non-redundant microRNA functional control in breast cancer molecular subtypes. Interface Focus. 2021 Jun; 11(4):20200073.

Denova-Gutierrez E, Rivera-Paredez B, Velazquez-Cruz R, Munoz-Aguirre P, Ramirez-Palacios P, Clark P, Ferretti JL, Salmeron J, Cointry GR. Relationship between physical activity, lean body mass, and bone mass in the Mexican adult population. Arch Osteoporos. 2021 Jun 8; 16(1):94.

Abreu Y Abreu AT, Milke-Garcia MP, Arguello-Arevalo GA, Calderon-de la Barca AM, Carmona-Sanchez RI, Consuelo-Sanchez A, Coss-Adame E, Garcia-Cedillo MF, Hernandez-Rosiles V, Icaza-Chavez ME, Martinez-Medina JN, Moran-Ramos S, Ochoa-Ortiz E, Reyes-Apodaca M, Rivera-Flores RL, Zamarripa-Dorsey F, Zarate-Mondragon F, Vazquez-Frias R. Dietary fiber and the microbiota: A narrative review by a group of experts from the Asociacion Mexicana de Gastroenterologia. Revista de Gastroenterología de México. 2021 Jul-Sep; 86(3):287-304.

Zampedri C, Martinez-Flores WA, Melendez-Zajgla J. The Use of Zebrafish Xenotransplant Assays to Analyze the Role of lncRNAs in Breast Cancer. Front Oncol. 2021; 11:687594.

Martinez-Damas MG, Genis-Mendoza AD, Perez-de la Cruz V, Canela-Tellez GD, Jimenez-Estrada I, Nicolini-Sanchez JH, Ramos-Chavez LA, Garcia S, Ramirez-Ramirez M, Coral-Vazquez RM. Epicatechin treatment generates resilience to chronic mild stress-induced depression in a murine model. Physiol Behav. 2021 Sep 1; 238:113466.

Mendez-Salazar EO, Vazquez-Mellado J, Casimiro-Soriguer CS, Dopazo J, Cubuk C, Zamudio-Cuevas Y, Francisco-Balderas A, Martinez-Flores K, Fernandez-Torres J, Lozada-Perez C, Pineda C, Sanchez-Gonzalez A, Silveira LH, Burguete-Garcia AI, Orbe-Orihuela C, Lagunas-Martinez A, Vazquez-Gomez A, Lopez-Reyes A, Palacios-Gonzalez B, Martinez-Nava GA. Taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism. Mol Med. 2021 May 24; 27(1):50.

Hernandez-Diazcouder A, Gonzalez-Ramirez J, Giacoman-Martinez A, Cardoso-Saldana G, Martinez-Martinez E, Osorio-Alonso H, Marquez-Velasco R, Sanchez-Gloria JL, Juarez-Vicuna Y, Gonzaga G, Sanchez-Lozada LG, Almanza-Perez JC, Sanchez-Munoz F. High fructose exposure modifies the amount of adipocyte-secreted microRNAs into extracellular vesicles in supernatants and plasma. PeerJ. 2021; 9:e11305.

Gonzalez-Pedroza MG, Argueta-Figueroa L, Garcia-Contreras R, Jimenez-Martinez Y, Martinez-Martinez E, Navarro-Marchal SA, Marchal JA, Morales-Luckie RA, Boulaiz H. Silver Nanoparticles from Annona muricata Peel and Leaf Extracts as a Potential Potent, Biocompatible and Low Cost Antitumor Tool. Nanomaterials (Basel). 2021 May 12; 11(5):.

Barajas-Martinez A, Ibarra-Coronado E, Fossion R, Toledo-Roy JC, Martinez-Garces V, Lopez-Rivera JA, Tello-Santoyo G, Lavin RD, Gomez JL, Stephens CR, Aguilar-Salinas CA, Estanol B, Torres N, Tovar AR, Resendis-Antonio O, Hiriart M, Frank A, Rivera AL. Sex Differences in the Physiological Network of Healthy Young Subjects. Frontiers in Physiology. 2021; 12:678507.

Montufar-Robles I, Soto ME, Jimenez-Morales S, Gamboa R, Huesca-Gomez C, Ramirez-Bello J. Polymorphisms in TNFAIP3, but not in STAT4, BANK1, BLK, and TNFSF4, are associated with susceptibility to Takayasu arteritis. Cell Immunol. 2021 Jul; 365:104375.

Romero-Cordoba SL, Salido-Guadarrama I, Rebollar-Vega R, Bautista-Pina V, Dominguez-Reyes C, Tenorio-Torres A, Villegas-Carlos F, Fernandez-Lopez JC, Uribe-Figueroa L, Alfaro-Ruiz L, Hidalgo-Miranda A. Comprehensive omic characterization of breast cancer in Mexican-Hispanic women. Nat Commun. 2021 Apr 14; 12(1):2245.

Cisneros-Villanueva M, Hidalgo-Perez L, Cedro-Tanda A, Pena-Luna M, Mancera-Rodriguez MA, Hurtado-Cordova E, Rivera-Salgado I, Martinez-Aguirre A, Jimenez-Morales S, Alfaro-Ruiz LA, Arellano-Llamas R, Tenorio-Torres A, Dominguez-Reyes C, Villegas-Carlos F, Rios-Romero M, Hidalgo-Miranda A. LINC00460 Is a Dual Biomarker That Acts as a Predictor for Increased Prognosis in Basal-Like Breast Cancer and Potentially Regulates Immunogenic and Differentiation-Related Genes. Front Oncol. 2021; 11:628027.

Aguilar-Ordonez I, Perez-Villatoro F, Garcia-Ortiz H, Barajas-Olmos F, Ballesteros-Villascan J, Gonzalez-Buenfil R, Fresno C, Garciarrubio A, Fernandez-Lopez JC, Tovar H, Hernandez-Lemus E, Orozco L, Soberon X, Morett E. Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights. PLoS One. 2021; 16(4):e0249773.

Ortega-Mora EI, Caballero-Sanchez U, Roman-Lopez TV, Rosas-Escobar CB, Gonzalez-Barrios JA, Romero-Hidalgo S, Mendez-Diaz M, Prospero-Garcia OE, Ruiz-Contreras AE. Allele-dosage genetic polymorphisms of cannabinoid receptor 1 predict attention, but not working memory performance in humans. Acta Psychol (Amst). 2021 Mar 31; 216:103299.

Perez-Rubio G, Falfan-Valencia R, Fernandez-Lopez JC, Ramirez-Venegas A, Hernandez-Zenteno RJ, Flores-Trujillo F, Silva-Zolezzi I. Genetic Factors Associated with COPD Depend on the Ancestral Caucasian/Amerindian Component in the Mexican Population. Diagnostics (Basel). 2021 Mar 27; 11(4):.

Buxton MA, Meraz-Cruz N, Sanchez BN, Foxman B, Castillo-Castrejon M, O'Neill MS, Vadillo-Ortega F. Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort. Int J Environ Res Public Health. 2021 Mar 26; 18(7):.

Fuentes-Nava G, Tirado-Sanchez A, Fernandez-Figueroa EA, Sanchez-Montes S, Becker I, Bonifaz A. Efficacy of imiquimod 5% cream as first-line management in cutaneous leishmaniasis caused by Leishmania mexicana. Rev Soc Bras Med Trop. 2021; 54:e0305-2020.

Valdez-Palomares F, Nambo-Venegas R, Uribe-Garcia J, Mendoza-Vargas A, Granados-Portillo O, Meraz-Cruz N, Palacios-Gonzalez B. Intestinal microbiota fingerprint in subjects with irritable bowel syndrome responders to a low FODMAP diet. Food Funct. 2021 Apr 7; 12(7):3206-3218.

Cruz-Burgos M, Losada-Garcia A, Cruz-Hernandez CD, Cortes-Ramirez SA, Camacho-Arroyo I, Gonzalez-Covarrubias V, Morales-Pacheco M, Trujillo-Bornios SI, Rodriguez-Dorantes M. New Approaches in Oncology for Repositioning Drugs: The Case of PDE5 Inhibitor Sildenafil. Front Oncol. 2021; 11:627229.

Flores-Ramirez I, Rivas-Torres MA, Rodriguez-Dorantes M, Gutierrez-Sagal R, Baranda-Avila N, Langley E. Oncogenic role of PinX1 in prostate cancer cells through androgen receptor dependent and independent mechanisms. J Steroid Biochem Mol Biol. 2021 Feb 26; 210:105858.

Garcia-Venzor A, Rueda-Zarazua B, Marquez-Garcia E, Maldonado V, Moncada-Morales A, Olivera H, Lopez I, Zuniga J, Melendez-Zajgla J. SARS-CoV-2 Direct Detection Without RNA Isolation With Loop-Mediated Isothermal Amplification (LAMP) and CRISPR-Cas12. Front Med (Lausanne). 2021; 8:627679.

Chavez-Reyes J, Escarcega-Gonzalez CE, Chavira-Suarez E, Leon-Buitimea A, Vazquez-Leon P, Morones-Ramirez JR, Villalon CM, Quintanar-Stephano A, Marichal-Cancino BA. Susceptibility for Some Infectious Diseases in Patients With Diabetes: The Key Role of Glycemia. Front Public Health. 2021; 9:559595.

Bliskunova T, Genis-Mendoza AD, Martinez-Magana JJ, Vega-Sevey JG, Jimenez-Genchi J, Roche A, Guzman R, Zapata L, Castro-Chavira S, Fernandez T, Villatoro-Velazquez JA, Camarena B, Fleiz-Bautista C, Bustos-Gamino M, Medina-Mora ME, Nicolini H. Association of MGAT4C with major neurocognitive disorder in the Mexican population. Gene. 2021 Apr 30; 778:145484.

Garcia-Olivares M, Romero-Cordoba S, Ortiz-Sanchez E, Garcia-Becerra R, Segovia-Mendoza M, Rangel-Escareno C, Halhali A, Larrea F, Barrera D. Regulation of anti-tumorigenic pathways by the combinatory treatment of calcitriol and TGF-beta in PC-3 and DU145 cells. J Steroid Biochem Mol Biol. 2021 May; 209:105831.

Flores-Alanis A, Cruz-Rangel A, Rodriguez-Gomez F, Gonzalez J, Torres-Guerrero CA, Delgado G, Cravioto A, Morales-Espinosa R. Molecular Epidemiology Surveillance of SARS-CoV-2: Mutations and Genetic Diversity One Year after Emerging. Pathogens. 2021 Feb 9; 10(2):.

Jacobo-Albavera L, Dominguez-Perez M, Medina-Leyte DJ, Gonzalez-Garrido A, Villarreal-Molina T. The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease. Int J Mol Sci. 2021 Feb 5; 22(4):.

Mayen-Lobo YG, Martinez-Magana JJ, Perez-Aldana BE, Ortega-Vazquez A, Genis-Mendoza AD, Davila-Ortiz de Montellano DJ, Soto-Reyes E, Nicolini H, Lopez-Lopez M, Monroy-Jaramillo N. Integrative Genomic-Epigenomic Analysis of Clozapine-Treated Patients with Refractory Psychosis. Pharmaceuticals (Basel). 2021 Feb 4; 14(2):.

Rosales-Rodriguez B, Nunez-Enriquez JC, Velazquez-Wong AC, Gonzalez-Torres C, Gaytan-Cervantes J, Jimenez-Hernandez E, Martin-Trejo JA, Campo-Martinez MLAD, Medina-Sanson A, Flores-Lujano J, Flores-Villegas LV, Penaloza-Gonzalez JG, Torres-Nava JR, Espinosa-Elizondo RM, Amador-Sanchez R, Miranda-Madrazo MR, Santillan-Juarez JD, Perez-Saldivar ML, Gurrola-Silva A, Orozco-Ruiz D, Solis-Labastida KA, Velazquez-Avina MM, Duarte-Rodriguez DA, Mata-Rocha M, Sepulveda-Robles OA, Ortiz-Maganda M, Bekker-Mendez VC, Jimenez-Morales S, Mejia-Arangure JM, Rosas-Vargas H. Copy Number Alterations are Associated With Associated With the Risk of Very Early Relapse in Pediatric B-lineage Acute Lymphoblastic Leukemia: A Nested Case-control MIGICCL Study. Arch Med Res. 2021 Feb 1; :.

Romero-Salas D, Solis-Cortes M, Zazueta-Islas HM, Flores-Vasquez F, Cruz-Romero A, Aguilar-Dominguez M, Salguero-Romero JL, de Leon AP, Fernandez-Figueroa EA, Lammoglia-Villagomez MA, Becker I, Sanchez-Montes S. Molecular detection of Theileria equi in horses from Veracruz, Mexico. Ticks Tick Borne Dis. 2021 May; 12(3):101671.

Azotla-Vilchis CN, Sanchez-Celis D, Agonizantes-Juarez LE, Suarez-Sanchez R, Hernandez-Hernandez JM, Pena J, Vazquez-Santillan K, Leyva-Garcia N, Ortega A, Maldonado V, Rangel C, Magana JJ, Cisneros B, Hernandez-Hernandez O. Transcriptome Analysis Reveals Altered Inflammatory Pathway in an Inducible Glial Cell Model of Myotonic Dystrophy Type 1. Biomolecules. 2021 Jan 26; 11(2):.

Espinosa M, Lizarraga F, Vazquez-Santillan K, Hidalgo-Miranda A, Pina-Sanchez P, Torres J, Garcia-Ramirez RA, Maldonado V, Melendez-Zajgla J, Ceballos-Cancino G. Coexpression of Smac/DIABLO and Estrogen Receptor in breast cancer. Cancer Biomark. 2021; 30(4):429-446.

Hernandez-Diaz Y, Gonzalez-Castro TB, Tovilla-Zarate CA, Juarez-Rojop IE, Lopez-Narvaez ML, Perez-Hernandez N, Rodriguez-Perez JM, Genis-Mendoza AD. Association between polymorphisms of FKBP5 gene and suicide attempt in a Mexican population: A case-control study. Brain Res Bull. 2021 Jan; 166:37-43.

Gonzalez-Castro TB, Tovilla-Zarate CA, Juarez-Rojop IE, Lopez-Narvaez ML, Perez-Hernandez N, Rodriguez-Perez JM, Genis-Mendoza AD. The role of gene polymorphisms, and analysis of peripheral and central levels of interleukins in suicidal behavior: A systematic review. J Affect Disord. 2021 Jan 15; 279:398-411.

Lopez-Sanchez GN, Dominguez-Perez M, Uribe M, Chavez-Tapia NC, Nuno-Lambarri N. Non-alcoholic fatty liver disease and microRNAs expression, how it affects the development and progression of the disease. Ann Hepatol. 2021 ; :.