El Dr. Felipe Vadillo Ortega es Médico Cirujano, con Maestría en Biología Molecular y Doctorado en Ciencias Biomédicas, egresado de la Facultad de Medicina, UNAM. Realizó dos posdoctorados en la University of Pennsylvania y en la Oregon Health Sciences University. Se desempeña como Director de Investigación del Instituto Nacional de Medicina Genómica y es Profesor Titular C de Tiempo Completo Definitivo de la Facultad de Medicina de la UNAM. La mayor parte de su carrera laboral la desarrolló en el Instituto Nacional de Perinatología entre 1987 y 2009. Entre 1999 y 2001 se desempeñó como Director del Departamento de Salud de la Universidad Iberoamericana. Tiene un nombramiento como Adjunct Professor en la School of Public Health de la University of Michigan. Su trabajo de investigación se ha centrado en el estudio de la fisiopatología de   diferentes complicaciones del embarazo humano, utilizando una mezcla de metodologías que incluyen técnicas moleculares y ensayos clínicos. Ha publicado 190 artículos en revistas indizadas, dos libros y 15 capítulos de libros. Es SNI nivel III desde 2004.  

Ha graduado a 60 alumnos de licenciatura, 22 de especialidades Médicas,15 de Maestría, 17 de Doctorado y 2 de posdoctorado.  Ha sido profesor visitante en la University of Pennsylvania, University of Michigan, World Health Organization, Universidad Autónoma de Sinaloa, Universidad Miguel Hernández, Wayne State University y National Institute of Child Health and Human Development. Es miembro titular de la Academia Nacional de Medicina, la Academia Mexicana de Ciencias, la Society for Reproductive Investigation, el Preterm Birth International Collaborative del cual es parte del Board of Directors, The Society for the Study of Reproduction y de 5 sociedades nacionales.

Ha recibido los siguientes premios: Menciones Honoríficas en los exámenes de grado de Maestría y Doctorado, Medalla Gabino Barreda de la UNAM, Premio Marcos y Celia Maus, Premio Aída Weiss, Becario Fogarty NIH, Dos veces el Premio de la Coordinación de los INSALUD, Becario John D. and Catherine T MacArthur, Premio Glaxo, Premio Silanes, Dos veces el Premio Gen, Premio Kellogg’s, premio Nacional de Nutrición de FUNSALUD y Premio Gregorio Pérez Palacios.

Contacto: fvadillo@inmegen.gob.mx; fvadillo@comunidad.unam.mx; www.inmegen.gob.mx

Artículos

• Omana-Guzman I, Ortiz-Hernandez L, Ancira-Moreno M, Godines-Enriquez M, O'Neill M, Vadillo-Ortega F. Association between maternal cardiometabolic markers and fetal growth in non-complicated pregnancies: a secondary analysis of the PRINCESA cohort. Sci Rep. 2024 Apr 20; 14(1):9096.

• Meraz-Cruz N, Manzano-Leon N, Sandoval-Colin DE, Garcia de Leon Mendez MDC, Quintana-Belmares R, Tapia LS, Osornio-Vargas AR, Buxton MA, O'Neill MS, Vadillo-Ortega F. Effects of PM(10) Airborne Particles from Different Regions of a Megacity on In Vitro Secretion of Cytokines by a Monocyte Line during Different Seasons. Toxics. 2024 Feb 15; 12(2):None.

• Garibay-Nieto N, Pedraza-Escudero K, Omana-Guzman I, Garces-Hernandez MJ, Villanueva-Ortega E, Flores-Torres M, Perez-Hernandez JL, Leon-Hernandez M, Laresgoiti-Servitje E, Palacios-Gonzalez B, Lopez-Alvarenga JC, Lisker-Melman M, Vadillo-Ortega F. Metabolomic Phenotype of Hepatic Steatosis and Fibrosis in Mexican Children Living with Obesity. Medicina (Kaunas). 2023 Oct 7; 59(10):None.

• Buxton MA, Castillo-Castrejon M, Godines-Enriquez M, Valentin-Cortes M, Morales-Hernandez V, de Arellano LM, Sanchez BN, Osornio-Vargas A, O'Neill MS, Vadillo-Ortega F. The pregnancy research on inflammation, nutrition, & city environment: systematic analyses study (PRINCESA) cohort, 2009-2015. Eur J Epidemiol. 2023 Sep; 38(9):1009-1018.

• Sandoval-Colin DE, Godines-Enriquez MS, Espejel-Nunez A, Beltran-Montoya JJ, Picazo-Mendoza DA, de la Cerda-Angeles JC, Bello-Chavolla OY, Meraz-Cruz N, Chavira-Suarez E, Vadillo-Ortega F. Cervicovaginal Cytokines to Predict the Onset of Normal and Preterm Labor: a Pseudo-longitudinal Study. Reprod Sci. 2023 Jan; 30(1):221-232.

• Razo-Azamar M, Nambo-Venegas R, Meraz-Cruz N, Guevara-Cruz M, Ibarra-Gonzalez I, Vela-Amieva M, Delgadillo-Velazquez J, Santiago XC, Escobar RF, Vadillo-Ortega F, Palacios-Gonzalez B. An early prediction model for gestational diabetes mellitus based on metabolomic biomarkers. Diabetol Metab Syndr. 2023 Jun 1; 15(1):116.

• Buxton MA, Heydarzadeh S, Gronlund CJ, Castillo-Castrejon M, Godines-Enriquez MS, O'Neill MS, Vadillo-Ortega F. Associations between Air Pollution Exposure and Blood Pressure during Pregnancy among PRINCESA Cohort Participants. Toxics. 2023 May 3; 11(5):None.

• Chavira-Suarez E, Hernandez-Olvera AL, Flores-Torres M, Celaya-Cruz KR, Gitler S, De la Cerda-Angeles JC, Espinosa-Maldonado NC, Flores-Jasso CF, Gutierrez H, Vadillo-Ortega F. Longitudinal large-scale changes in maternal circulating microRNAs associated with gestation-related compartments, fetal sex, and growth during and post-pregnancy. Genomics. 2023 May; 115(3):110628.

• Nambo-Venegas R, Palacios-Gonzalez B, Mas-Oliva J, Aurioles-Amozurrutia AK, Cruz-Rangel A, Moreno A, Hidalgo-Miranda A, Rodriguez-Dorantes M, Vadillo-Ortega F, Xicohtencatl-Cortes J, Ruiz-Olmedo MI, Reyes-Grajeda JP. Conversion of M1 Macrophages to Foam Cells: Transcriptome Differences Determined by Sex. Biomedicines. 2023 Feb 8; 11(2):None.

• Oliva-Sanchez PF, Vadillo-Ortega F, Bojalil-Parra R, Martinez-Kobeh JP, Perez-Perez JR, Perez-Avalos JL. Risk factors for COVID-19 severe complications comparing three major epidemiological waves: An approach from primary health care in Mexico. Am J Med Genet. 2022 NOV; 54(11):None.

• Oliva-Sanchez PF, Lopez-Landeros S, Velazquez-Trejo DA, Brenner-Muslera E, Martinez-Kobeh JP, Gonzalez-Reyes D, Guasque-Gil I, Vadillo-Ortega F. Association between atmospheric pollutants exposition and morbidity and mortality epidemiological indicators of Covid-19 in the Valley of Mexico. Salud Publica de Mexico. 2022 SEP-OCT; 64(5):453 - 463.

• Chavira-Suarez E, Reyes-Castro LA, Lopez-Tenorio II, Vargas-Hernandez L, Rodriguez-Gonzalez GL, Chavira R, Zarate-Segura P, Dominguez-Lopez A, Vadillo-Ortega F, Zambrano E. Sex-differential RXR alpha gene methylation effects on mRNA and protein expression in umbilical cord of the offspring rat exposed to maternal obesity. Front Cell Dev Biol. 2022 AUG 16; 10:None.

• Flores-Garcia LC, Ventura-Gallegos JL, Romero-Cordoba SL, Hernandez-Juarez AJ, Naranjo-Meneses MA, Garcia-Garcia E, Mendez JP, Cabrera-Quintero AJ, Ramirez-Ruiz A, Pedraza-Sanchez S, Meraz-Cruz N, Vadillo-Ortega F, Zentella-Dehesa A. Sera from women with different metabolic and menopause states differentially regulate cell viability and Akt activation in a breast cancer in-vitro model. PLoS One. 2022; 17(4):e0266073.

• Cruz-Rangel A, Gomez-Romero L, Cisneros-Villanueva M, de Anda Jauregui G, Luna-Pineda V, Cedro-Tanda A, Campos-Romero A, Mendoza-Vargas A, Reyes-Grajeda JP, Hidalgo-Miranda A, Herrera LA, Vadillo-Ortega F. End-point RT-PCR based on a conservation landscape for SARS-COV-2 detection. Sci Rep. 2022 Mar 19; 12(1):4759.

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  Castro-Leyva V, Arenas-Huertero F, Espejel-Nunez A, Giono Cerezo S, Flores-Pliego A, Espino Y Sosa S, Reyes-Munoz E, Vadillo-Ortega F, Borboa-Olivares H, Camacho-Arroyo I, Estrada-Gutierrez G. miR-21 differentially regulates IL-1beta and IL-10 expression in human decidual cells infected with streptococcus B. Reprod Biol. 2022 Mar; 22(1):100604.

• Omana-Guzman LI, Ortiz-Hernandez L, Ancira-Moreno M, Morales-Hernandez V, O'Neill MS, Vadillo-Ortega F. Association of pre-pregnancy body mass index and rate of weight gain during pregnancy with maternal indicators of cardiometabolic risk. Nutr Diabetes. 2021 Nov 25; 11(1):36.

• Delgadillo-Velazquez JA, Nambo-Venegas R, Patino N, Meraz-Cruz N, Razo-Azamar M, Guevara-Cruz M, Fonseca M, Pale Montero LE, Ibarra-Gonzalez I, Vela-Amieva M, Vadillo-Ortega F, Palacios-Gonzalez B. Metabolic flexibility during normal pregnancy allows appropriate adaptation during gestation independently of BMI. Clin Nutr ESPEN. 2021 Aug; 44:254-262.

• Buxton MA, Meraz-Cruz N, Sanchez BN, Foxman B, Castillo-Castrejon M, O'Neill MS, Vadillo-Ortega F. Timing of Cervico-Vaginal Cytokine Collection during Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort. Int J Environ Res Public Health. 2021 Mar 26; 18(7):.

• Herrera LA, Hidalgo-Miranda A, Reynoso-Noveron N, Meneses-Garcia AA, Mendoza-Vargas A, Reyes-Grajeda JP, Vadillo-Ortega F, Cedro-Tanda A, Penaloza F, Frias-Jimenez E, Arriaga-Canon C, Ruiz R, Angulo O, Lopez-Villasenor I, Amador-Bedolla C, Vilar-Compte D, Cornejo P, Cisneros-Villanueva M, Hurtado-Cordova E, Cendejas-Orozco M, Hernandez-Morales JS, Moreno B, Hernandez-Cruz IA, Herrera CA, Garcia F, Gonzalez-Woge MA, Munguia-Garza P, Luna-Maldonado F, Sanchez-Vizcarra A, Osnaya VG, Medina-Molotla N, Alfaro-Mora Y, Caceres-Gutierrez RE, Tolentino-Garcia L, Rosas-Escobar P, Roman-Gonzalez SA, Escobar-Arrazola MA, Canseco-Mendez JC, Ortiz-Soriano DR, Dominguez-Ortiz J, Gonzalez-Barrera AD, Aparicio-Bautista DI, Cruz-Rangel A, Alarcon-Zendejas AP, Contreras-Espinosa L, Gonzalez R, Guerra-Calderas L, Meraz-Rodriguez MA, Montalvo-Casimiro M, Montiel-Manriquez R, Torres-Arciga K, Venegas D, Juarez-Gonzalez V, Guajardo-Barreto X, Monroy-Martinez V, Guillen D, Fernandez J, Herrera J, Leon-Rodriguez R, Canela-Perez I, Ruiz-Ordaz BH, Valdez-Vazquez R, Bertin-Montoya J, Niembro-Ortega M, Villegas-Acosta L, Lopez-Castillo D, Soriano-Rios A, Gastelum-Ramos M, Zamora-Barandas T, Morales-Baez J, Garcia-Rodriguez M, Garcia-Martinez M, Nieto-Patlan E, Quirasco-Baruch M, Lopez-Martinez I, Ramirez-Gonzalez E, Olivera-Diaz H, Escobar-Escamilla N. Saliva is a reliable and accessible source for the detection of SARS-CoV-2. Int J Infect Dis. 2021 Apr; 105:83-90.

• Estrada-Gutierrez G, Zambrano E, Polo-Oteyza E, Cardona-Perez A, Vadillo-Ortega F. Intervention during the first 1000 days in Mexico. Nutr Rev. 2020 Dec 1; 78(x):80-90.

• Chavira-Suarez E, Rosel-Pech C, Polo-Oteyza E, Ancira-Moreno M, Ibarra-Gonzalez I, Vela-Amieva M, Meraz-Cruz N, Aguilar-Salinas C, Vadillo-Ortega F. Simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index (BMI) and waist-to-height ratio (WHtR). PLoS One. 2020; 15(8):e0237917.

• Meraz-Cruz N, Vadillo-Ortega F, Jimenez-Garduno AM, Ortega A. Thermal stability of human matrix metalloproteinases. Heliyon. 2020 May; 6(5):e03865.

• Alhousseini A, Vadillo-Ortega F, Palacios-Gonzalez B, Theis KR, Winters AD, Hassan SS, Meraz-Cruz N. Differential Secretion of Inflammatory Cytokines by Human Trophoblasts in the Presence of Escherichia coli, Lactobacillus crispatus, and Lactobacillus jensenii. Gynecol Obstet Invest. 2020; 85(3):277-283.

• Buxton MA, Meraz-Cruz N, Sanchez BN, Foxman B, Gronlund CJ, Beltran-Montoya J, Castillo-Castrejon M, O'Neill MS, Vadillo-Ortega F. Repeated Measures of Cervicovaginal Cytokines during Healthy Pregnancy: Understanding "Normal" Inflammation to Inform Future Screening. Am J Perinatol. 2020 Apr 12; 37:.

• Ancira-Moreno M, O'Neill MS, Rivera-Dommarco JA, Batis C, Rodriguez Ramirez S, Sanchez BN, Castillo-Castrejon M, Vadillo-Ortega F. Dietary patterns and diet quality during pregnancy and low birthweight: The PRINCESA cohort. Matern Child Nutr. 2020 Jul; 16(3):e12972.

• Chavira-Suarez E, Ramirez-Mendieta AJ, Martinez-Gutierrez S, Zarate-Segura P, Beltran-Montoya J, Espinosa-Maldonado NC, de la Cerda-Angeles JC, Vadillo-Ortega F. Influence of pre-pregnancy body mass index (p-BMI) and gestational weight gain (GWG) on DNA methylation and protein expression of obesogenic genes in umbilical vein. PLoS One. 2019; 14(12):e0226010.

• Yan Y, Gomez-Lopez N, Basij M, Shahvari AV, Vadillo-Ortega F, Hernandez-Andrade E, Hassan SS, Romero R, MehrMohammadi M. Photoacoustic imaging of the uterine cervix to assess collagen and water content changes in murine pregnancy. Biomed Opt Express. 2019 Sep 1; 10(9):4643-4655.

• Mejia-Terrazas GE, Ruiz-Suarez M, Vadillo-Ortega F, Franco Y Bourland RE, Lopez-Munoz E. Effect of interscalene nerve block on the inflammatory response in shoulder surgery: a randomized trial. J Shoulder Elbow Surg. 2019 Jun 18; 28:.

• Buxton MA, Meraz-Cruz N, Sanchez BN, Gronlund CJ, Foxman B, Vadillo-Ortega F, O'Neill MS. Air pollution and inflammation: Findings from concurrent repeated measures of systemic and reproductive tract cytokines during term pregnancy in Mexico City. Sci Total Environ. 2019 Sep 1; 681:235-241.

• Vallee Marcotte B, Guenard F, Marquis J, Charpagne A, Vadillo-Ortega F, Tejero ME, Binia A, Vohl MC. Genetic Risk Score Predictive of the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation in a Mexican Population. Nutrients. 2019 Mar 29; 11(4):.

• Ancira-Moreno M, Vadillo-Ortega F, Rivera-Dommarco JA, Sanchez BN, Pasteris J, Batis C, Castillo-Castrejon M, O'Neill MS. Gestational weight gain trajectories over pregnancy and their association with maternal diet quality: Results from the PRINCESA cohort. Nutrition. 2019 Sep; 65:158-166.

• Romero-Ibarguengoitia ME, Vadillo-Ortega F, Caballero AE, Ibarra-Gonzalez I, Herrera-Rosas A, Serratos-Canales MF, Leon-Hernandez M, Gonzalez-Chavez A, Mummidi S, Duggirala R, Lopez-Alvarenga JC. Correction: Family history and obesity in youth, their effect on acylcarnitine/aminoacids metabolomics and non-alcoholic fatty liver disease (NAFLD). Structural equation modeling approach. PLoS One. 2018; 13(5):e0198379.

• Romero-Ibarguengoitia ME, Vadillo-Ortega F, Caballero AE, Ibarra-Gonzalez I, Herrera-Rosas A, Serratos-Canales MF, Leon-Hernandez M, Gonzalez-Chavez A, Mummidi S, Duggirala R, Lopez-Alvarenga JC. Family history and obesity in youth, their effect on acylcarnitine/aminoacids metabolomics and non-alcoholic fatty liver disease (NAFLD). Structural equation modeling approach. PLoS One. 2018; 13(2):e0193138.

• Miller D, Romero R, Unkel R, Xu Y, Vadillo-Ortega F, Hassan SS, Gomez-Lopez N. CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses. Journal of Leukocyte Biology. 2018 Apr; 103(4):761-775.

• Chavez-Lizarraga D, Zarate-Segura P, Beltran-Montoya J, Canchola-Sotelo C, Vadillo-Ortega F, Chavira-Suarez E. DNA Methylation Variability in a Single Locus of the RXRalpha Promoter from Umbilical Vein Blood at Term Pregnancy. Biochem Genet. 2018 Jun; 56(3):210-224.

• Avila-Vergara MA, Peraza-Garay FJ, Meraz-Cruz N, Hernandez-Guerrero C, Palacios-Gonzalez B, Vadillo-Ortega F. Association of Intron-2 Variable Numbers of an 86-bp Tandem Repeat-Polymorphisms of Interleukin-1 Receptor Antagonist Gene and Idiopathic Recurrent Spontaneous Abortion. Rev Invest Clin. 2018; 70(2):96-102.

• Escalona-Guzman AR, Hernandez-Garcia R, Vadillo-Ortega F, Lopez-Marure R, Mejia-Rangel J, Mitre-Aguilar IB, Cabrera-Quintero AJ, Zentella-Dehesa A. Effect of soluble factors derived from ZR 75.30 breast cancer cells on endothelial activation. Int J Clin Exp Pathol. 2018; 11(2):685-694.

• Binia A., Gosoniu LM., Martínez-Soria D., Vadillo-Ortega F., Valet P., Kussmann M., Silva Zolezzi I., Tejero ME.. Supplementation with ω3 polyunsaturated fatty acids decreases fasting insulin and hemoglobin A1c levels in healthy Mexican adults: the role of PPARγ2 P12A. FASEB Journal. 2017 OCT; 31(11):None.

• Espino Y Sosa S, Flores-Pliego A, Espejel-Nunez A, Medina-Bastidas D, Vadillo-Ortega F, Zaga-Clavellina V, Estrada-Gutierrez G. New Insights into the Role of Matrix Metalloproteinases in Preeclampsia. Int J Mol Sci. 2017 Jul 20; 18(7):.

• Aragón-Hernández JP., Ávila-Vergara MA., Beltrán-Montoya J., CalderónCisneros E., Caldiño-Soto F., Castilla-Zenteno A., García-Espinosa M., Gil-Márquez J., Gudiño-Ruiz EN., Hernández-Rivera C., Loya-Montiel L., Salvador-Domínguez G., Vadillo-Ortega F.. Protocolo clínico para inducción del trabajo de parto: propuesta de consenso. Ginecología y Obstetricia de México. Ginecol Obstet Mex. 2017 MAY; 85(5):None.

• Binia A, Vargas-Martinez C, Ancira-Moreno M, Gosoniu LM, Montoliu I, Gamez-Valdez E, Soria-Contreras DC, Angeles-Quezada A, Gonzalez-Alberto R, Fernandez S, Martinez-Conde D, Hernandez-Moran B, Ramirez-Solano M, Perez-Ortega C, Rodriguez-Carmona Y, Castan I, Rubio-Aliaga I, Vadillo-Ortega F, Marquez-Velasco R, Bojalil R, Lopez-Alvarenga JC, Valet P, Kussmann M, Silva-Zolezzi I, Tejero ME. Improvement of cardiometabolic markers after fish oil intervention in young Mexican adults and the role of PPARalpha L162V and PPARgamma2 P12A. J Nutr Biochem. 2017 Feb 10; 43:98-106.

• Tejero ME., López-Martínez ME., Cardenas-Ovando RA., Rangel Escareño C., Binia A., Vargas-Martinez C., Ancira M., Gámez-Valdez E., Martinez-Soria D., Sebastian Medina L., Angeles-Quezada A., Gonzalez-Alberto R., Fernández S., Martínez-Conde D., Hernández-Morán B., Ramirez-Solano M., Rubio-Aliaga I., Vadillo-Ortega F., Kussmann M., Silva Zolezzi I.. Differences in the transcriptome of responders and non-responders on glucose metabolism markers after fish oil supplementation. Am J Med Genet. 2017 FEB; 31(11):None.

• Sánchez-Carrillo V., Ávila-Vergara MA., Peraza-Garay F., Vadillo-Ortega F., Palacios-González B., García-Benavente D.. Complicaciones perinatales asociadas con la ganancia excesiva de peso durante el embarazo. Ginecol Obstet Mex. 2017 FEB; 85(2):None.

• Polo-Oteyza E, Ancira-Moreno M, Rosel-Pech C, Sanchez-Mendoza MT, Salinas-Martinez V, Vadillo-Ortega F. An intervention to promote physical activity in Mexican elementary school students: building public policy to prevent noncommunicable diseases. Nutr Rev. 2017 Jan; 75(suppl 1):70-78.

• Flores-Pliego A, Espejel-Nunez A, Castillo-Castrejon M, Meraz-Cruz N, Beltran-Montoya J, Zaga-Clavellina V, Nava-Salazar S, Sanchez-Martinez M, Vadillo-Ortega F, Estrada-Gutierrez G. Matrix Metalloproteinase-3 (MMP-3) Is an Endogenous Activator of the MMP-9 Secreted by Placental Leukocytes: Implication in Human Labor. PLoS One. 2016; 10(12):e0145366.

• Gomez-Lopez N, Romero R, Arenas-Hernandez M, Ahn H, Panaitescu B, Vadillo-Ortega F, Sanchez-Torres C, Salisbury KS, Hassan SS. In vivo T-cell activation by a monoclonal alphaCD3epsilon antibody induces preterm labor and birth. Am J Reprod Immunol. 2016 Nov; 76(5):386-390.

• Manzano-Leon N, Serrano-Lomelin J, Sanchez BN, Quintana-Belmares R, Vega E, Vazquez-Lopez I, Rojas-Bracho L, Lopez-Villegas MT, Vadillo-Ortega F, De Vizcaya-Ruiz A, Rosas Perez I, O'Neill MS, Osornio-Vargas AR. TNFalpha and IL-6 Responses to Particulate Matter : Variation According to PM Size, Season, and Polycyclic Aromatic Hydrocarbon and Soil Content. Environ Health Perspect. 2016 Sep 15; 124(4):406-12.

• Ruiz-Contreras AE, Roman-Lopez TV, Caballero-Sanchez U, Rosas-Escobar CB, Ortega-Mora EI, Barrera-Tlapa MA, Romero-Hidalgo S, Carrillo-Sanchez K, Hernandez-Morales S, Vadillo-Ortega F, Gonzalez-Barrios JA, Mendez-Diaz M, Prospero-Garcia O. Because difficulty is not the same for everyone: the impact of complexity in working memory is associated with cannabinoid 1 receptor genetic variation in young adults. Memory. 2016 Apr 25; 35:1-9.

• Beltrán-Montoya J., Escudero-Gontes S., Martínez-Huerta., Ávila-Vergara MA., Morales-Hernández V., Canchola-Sotelo C., Palacios-González B., Vadillo-Ortega F.. Ensayo piloto del uso de pruebas moleculares para el diagnóstico de infecciones cervicovaginales en pacientes embarazadas. Ginecol Obstet Mex. 2016 FEB; 84(8):None.

• Ortiz-Alegría LB., Cañedo-Solares I., Vadillo-Ortega F., Castillo-Castrejon M., Correa D.. Potential of HMEC-1 line and HUVEC primary culture cells to study the neonatal IgG Fc receptor in vitro. Am J Med Genet. 2016 ENE; 12(1):None.

• Romero-Valdovinos M, Galvan-Montano A, Olivo-Diaz A, Maravilla P, Bobadilla NA, Vadillo-Ortega F, Flisser A. The Amniotic Band Syndrome in the Rat Is Associated with the Activation of Transforming Growth Factor beta. Am J Pathol. 2015 Jun 5; 185(8):2076-82.

• Rivera-Gonzalez LO, Zhang Z, Sanchez BN, Zhang K, Brown DG, Rojas-Bracho L, Osornio-Vargas A, Vadillo-Ortega F, O'Neill MS. An assessment of air pollutant exposure methods in Mexico City, Mexico. J Air Waste Manag Assoc. 2015 May; 65(5):581-91.

• Palacios-Gonzalez B, Vadillo-Ortega F, Polo-Oteyza E, Sanchez T, Ancira-Moreno M, Romero-Hidalgo S, Meraz N, Antuna-Puente B. Irisin levels before and after physical activity among school-age children with different BMI: A direct relation with leptin. Obesity (Silver Spring). 2015 Apr; 23(4):729-32.

• Romero-Valdovinos M, Bobadilla-Sandoval N, Flisser A, Vadillo-Ortega F. The epithelial mesenchymal transition process may contribute to the pathogenesis of amniotic band syndrome. Med Hypotheses. 2014 Jun 11; 83(3):306-11.

• Pruneda Padilla Yunuen, Ceballos Angeles Armida, Ibarra Gonzalez Isabel, Vela Amieva Marcela, Vadillo Ortega Felipe, Palacios Gonzalez Berenice. Longitudinal Amino-Acid Seric Profiles in Obese and Normal Women with Normal Non-Complicated Pregnancies. Reproductive Sciences. 2014 MAR; 21:265A-265A.

• Fleischer NL, Merialdi M, van Donkelaar A, Vadillo-Ortega F, Martin RV, Betran AP, Souza JP, O'Neill MS. Outdoor Air Pollution, Preterm Birth, and Low Birth Weight: Analysis of the World Health Organization Global Survey on Maternal and Perinatal Health. Environ Health Perspect. 2014 Feb 7; 122(4):425-30.

• Zaga-Clavellina V, Parra-Covarrubias A, Ramirez-Peredo J, Vega-Sanchez R, Vadillo-Ortega F. The potential role of prolactin as a modulator of the secretion of pro-inflammatory mediators in chorioamniotic membranes in term human gestation. Am J Obstet Gynecol. 2014 Feb 1; 211(1):48.e1-6.

• Vadillo-Ortega F, Osornio-Vargas A, Buxton MA, Sanchez BN, Rojas-Bracho L, Viveros-Alcaraz M, Castillo-Castrejon M, Beltran-Montoya J, Brown DG, O'Neill MS. Air pollution, inflammation and preterm birth: A potential mechanistic link. Med Hypotheses. 2013 Dec 11; 82(2):219-24.

• Castillo-Castrejon M, Meraz-Cruz N, Gomez-Lopez N, Flores-Pliego A, Beltran-Montoya J, Viveros-Alcaraz M, Vadillo-Ortega F. Choriodecidual Cells From Term Human Pregnancies Show Distinctive Functional Properties Related to the Induction of Labor. Am J Reprod Immunol. 2013 Nov 29; 71(1):86-93.

• Smarr MM, Vadillo-Ortega F, Castillo-Castrejon M, O'Neill MS. The use of ultrasound measurements in environmental epidemiological studies of air pollution and fetal growth. Curr Opin Pediatr. 2013 Apr; 25(2):240-6.

• Balas-Nakash M, Perichart-Perera O, Benitez-Arciniega A, Tolentino-Dolores M, Mier-Cabrera J, Vadillo-Ortega F. Asociacion entre adiposidad, inflamacion y factores de riesgo cardiovascular en un grupo de escolares mexicanos. Gac Med Mex. 2013 Mar-Apr; 149(2):196-203.

• Gomez-Lopez N, Vega-Sanchez R, Castillo-Castrejon M, Romero R, Cubeiro-Arreola K, Vadillo-Ortega F. Evidence for a role for the adaptive immune response in human term parturition. Am J Reprod Immunol. 2013 Mar; 69(3):212-30.

• Pennell CE, Vadillo-Ortega F, Olson DM, Ha EH, Williams S, Frayling TM, Dolan S, Katz M, Merialdi M, Menon R. Preterm Birth Genome Project (PGP) -- validation of resources for preterm birth genome-wide studies. J Perinat Med. 2013 Jan; 41(1):45-9.

• Manzano-Leon N, Quintana R, Sanchez B, Serrano J, Vega E, Vazquez-Lopez I, Rojas-Bracho L, Lopez-Villegas T, O'Neill MS, Vadillo-Ortega F, De Vizcaya-Ruiz A, Rosas I, Osornio-Vargas AR. Variation in the composition and in vitro proinflammatory effect of urban particulate matter from different sites. J Biochem Mol Toxicol. 2013 Jan; 27(1):87-97.

• Perichart-Perera O, Balas-Nakash M, Rodriguez-Cano A, Legorreta-Legorreta J, Parra-Covarrubias A, Vadillo-Ortega F. Low Glycemic Index Carbohydrates versus All Types of Carbohydrates for Treating Diabetes in Pregnancy: A Randomized Clinical Trial to Evaluate the Effect of Glycemic Control. Int J Endocrinol. 2012; 2012:296017.

• O'Neill MS, Osornio-Vargas A, Buxton MA, Sanchez BN, Rojas-Bracho L, Castillo-Castrejon M, Mordhukovich IB, Brown DG, Vadillo-Ortega F. Air pollution, inflammation and preterm birth in Mexico City: study design and methods. Sci Total Environ. 2013 Mar 15; 448:79-83.

• Gomez-Lopez N, Hernandez-Santiago S, Lobb AP, Olson DM, Vadillo-Ortega F. Normal and premature rupture of fetal membranes at term delivery differ in regional chemotactic activity and related chemokine/cytokine production. Reprod Sci. 2013 Mar; 20(3):276-84.

• Beltran-Montoya JJ, Herrerias-Canedo T, Arzola-Paniagua A, Vadillo-Ortega F, Duenas-Garcia OF, Rico-Olvera H. A randomized, clinical trial of ketorolac tromethamine vs ketorolac trometamine plus complex B vitamins for cesarean delivery analgesia. Saudi J Anaesth. 2012 Jul; 6(3):207-12.

• Gomez-Lopez N, Vadillo-Ortega F, Estrada-Gutierrez G. Combined boyden-flow cytometry assay improves quantification and provides phenotypification of leukocyte chemotaxis. PLoS One. 2011; 6(12):e28771.

• Vadillo-Ortega F, Perichart-Perera O, Espino S, Avila-Vergara MA, Ibarra I, Ahued R, Godines M, Parry S, Macones G, Strauss JF. Effect of supplementation during pregnancy with L-arginine and antioxidant vitamins in medical food on pre-eclampsia in high risk population: randomised controlled trial. BMJ. 2011; 342:d2901.

• Gomez-Lopez N, Vadillo-Perez L, Hernandez-Carbajal A, Godines-Enriquez M, Olson DM, Vadillo-Ortega F. Specific inflammatory microenvironments in the zones of the fetal membranes at term delivery. Am J Obstet Gynecol. 2011 Sep; 205(3):235.e15-24.

• Ruiz-Contreras AE, Delgado-Herrera M, Garcia-Vaca PA, Almeida-Rosas GA, Soria-Rodriguez G, Soriano-Bautista A, Cadena-Valencia J, Bazan-Frias JR, Gomez-Lopez N, Espejel-Nunez A, Vadillo-Ortega F, Carrillo-Sanchez K, Verdin-Reyes JC, March-Mifsut S, Mendez-Diaz M, Prospero-Garcia O. Involvement of the AATn polymorphism of the CNR1 gene in the efficiency of procedural learning in humans. Neurosci Lett. 2011 May 2; 494(3):202-6.

• Gomez-Lopez N, Vadillo-Perez L, Nessim S, Olson DM, Vadillo-Ortega F. Choriodecidua and amnion exhibit selective leukocyte chemotaxis during term human labor. Am J Obstet Gynecol. 2011 Apr; 204(4):364.e9-16.

• Zaga-Clavellina V, Garcia-Lopez G, Flores-Pliego A, Merchant-Larios H, Vadillo-Ortega F. In vitro secretion and activity profiles of matrix metalloproteinases, MMP-9 and MMP-2, in human term extra-placental membranes after exposure to Escherichia coli. Reprod Biol Endocrinol. 2011; 9:13.

• Vega-Sanchez R, de Jesus-Torres E, Arenas-Hernandez M, Beltran-Montoya J, Maida-Claros R, Estrada-Gutierrez G, Vadillo-Ortega F. Expresion de moleculas de adhesion celular en la interfase materno fetal al termino de la gestacion humana. Ginecol Obstet Mex. 2010 Dec; 78(12):677-84.

• Garfias Y, Zaga-Clavellina V, Vadillo-Ortega F, Osorio M, Jimenez-Martinez MC. Amniotic membrane is an immunosuppressor of peripheral blood mononuclear cells. Immunol Invest. 2011; 40(2):183-96.

• Balas-Nakash M, Benitez-Arciniega A, Perichart-Perera O, Valdes-Ramos R, Vadillo-Ortega F. The effect of exercise on cardiovascular risk markers in Mexican school-aged children: comparison between two structured group routines. Salud Publica de Mexico. 2010 Sep-Oct; 52(5):398-405.

• Estrada-Gutierrez G, Gomez-Lopez N, Zaga-Clavellina V, Giono-Cerezo S, Espejel-Nunez A, Gonzalez-Jimenez MA, Espino y Sosa S, Olson DM, Vadillo-Ortega F. Interaction between pathogenic bacteria and intrauterine leukocytes triggers alternative molecular signaling cascades leading to labor in women. Infect Immun. 2010 Nov; 78(11):4792-9.

• Vega-Sanchez R, Barajas-Vega HA, Rozada G, Espejel-Nunez A, Beltran-Montoya J, Vadillo-Ortega F. Association between adiposity and inflammatory markers in maternal and fetal blood in a group of Mexican pregnant women. Br J Nutr. 2010 Dec; 104(12):1735-9.

• Perichart-Perera O, Balas-Nakash M, Rodriguez-Cano A, Munoz-Manrique C, Monge-Urrea A, Vadillo-Ortega F. Correlates of dietary energy sources with cardiovascular disease risk markers in Mexican school-age children. J Am Diet Assoc. 2010 Feb; 110(2):253-60.

• Gomez-Lopez N, Laresgoiti-Servitje E, Olson DM, Estrada-Gutierrez G, Vadillo-Ortega F. The role of chemokines in term and premature rupture of the fetal membranes: a review. Biol Reprod. 2010 May; 82(5):809-14.

• Montes-Sanchez D, Ventura JL, Mitre I, Frias S, Michan L, Espejel-Nunez A, Vadillo-Ortega F, Zentella A. Glycosylated VCAM-1 isoforms revealed in 2D western blots of HUVECs treated with tumoral soluble factors of breast cancer cells. BMC Chem Biol. 2009; 9:7.

• Vega-Sanchez R, Gomez-Lopez N, Flores-Pliego A, Clemente-Galvan S, Estrada-Gutierrez G, Zentella-Dehesa A, Maida-Claros R, Beltran-Montoya J, Vadillo-Ortega F. Placental blood leukocytes are functional and phenotypically different than peripheral leukocytes during human labor. J Reprod Immunol. 2010 Jan; 84(1):100-10.

• Perichart-Perera O, Balas-Nakash M, Parra-Covarrubias A, Rodriguez-Cano A, Ramirez-Torres A, Ortega-Gonzalez C, Vadillo-Ortega F. A medical nutrition therapy program improves perinatal outcomes in Mexican pregnant women with gestational diabetes and type 2 diabetes mellitus. Diabetes Educ. 2009 Nov-Dec; 35(6):1004-13.

• Gomez-Lopez N, Estrada-Gutierrez G, Jimenez-Zamudio L, Vega-Sanchez R, Vadillo-Ortega F. Fetal membranes exhibit selective leukocyte chemotaxic activity during human labor. J Reprod Immunol. 2009 Jun; 80(1-2):122-31.

• Balas-Nakash M, Villanueva-Quintana A, Vadillo-Ortega F, Perichart-Perera O. Validacion del uso de formulas para estimar el gasto energetico en reposo en ninos mexicanos de 9 a 12 anos de edad con y sin obesidad. Rev Invest Clin. 2008 Sep-Oct; 60(5):395-402.

• Perichart-Perera O, Balas-Nakash M, Ortiz-Rodriguez V, Moran-Zenteno JA, Guerrero-Ortiz JL, Vadillo-Ortega F. Programa para mejorar marcadores de riesgo cardiovascular en escolares mexicanos. Salud Publica de Mexico. 2008 May-Jun; 50(3):218-26.

• Vega Sanchez R, Castillo Castrejon M, Hornelas Orozco Y, Gomez Lopez N, Beltran Montoya J, Vadillo Ortega F. Analisis tridimensional de la estructura de las membranas corioamnioticas humanas al termino de la gestacion. Ginecol Obstet Mex. 2008 Jan; 76(1):38-44.

• Gomez Lopez N, Estrada Gutierrez G, Beltran Montoya J, Espejel Nunez A, Vadillo Ortega F. Identificacion del perfil de metaloproteasas de matriz extracelular en membranas corioamnioticas de embarazos a termino y pretermino mediante microarreglos solubles. Ginecol Obstet Mex. 2008 Jan; 76(1):32-7.

• Espejel Nunez A, Godines Enriquez M, Buendia Diaz G, Guzman Gonzalez E, Beltran Montoya J, Vadillo Ortega F. Cambios en la concentracion de la interleucina 6 en exudados cervicovaginales en trabajo de parto. Ginecol Obstet Mex. 2008 Jan; 76(1):3-8.

• Flores Pliego A, Beltran Montoya J, Gomez Lopez N, Vadillo Ortega F. Evidencia de que las subpoblaciones de leucocitos periplacentarios al termino de la gestacion poseen propiedades funcionales relacionadas con la induccion del trabajo de parto. Ginecol Obstet Mex. 2008 Jan; 76(1):45-51.

• Zaga-Clavellina V, Garcia-Lopez G, Flores-Herrera H, Espejel-Nunez A, Flores-Pliego A, Soriano-Becerril D, Maida-Claros R, Merchant-Larios H, Vadillo-Ortega F. In vitro secretion profiles of interleukin (IL)-1beta, IL-6, IL-8, IL-10, and TNF alpha after selective infection with Escherichia coli in human fetal membranes. Reprod Biol Endocrinol. 2007; 5:46.

• Mier-Cabrera J, Genera-Garcia M, De la Jara-Diaz J, Perichart-Perera O, Vadillo-Ortega F, Hernandez-Guerrero C. Effect of vitamins C and E supplementation on peripheral oxidative stress markers and pregnancy rate in women with endometriosis. Int J Gynaecol Obstet. 2008 Mar; 100(3):252-6.

• Garcia-Lopez G, Vadillo-Ortega F, Merchant-Larios H, Maida-Claros R, Osorio M, Soriano-Becerril D, Flores-Herrera H, Beltran-Montoya J, Garfias-Becerra Y, Zaga-Clavellina V. Evidence of in vitro differential secretion of 72 and 92 kDa type IV collagenases after selective exposure to lipopolysaccharide in human fetal membranes. Mol Hum Reprod. 2007 Jun; 13(6):409-18.

• Perichart-Perera O, Balas-Nakash M, Schiffman-Selechnik E, Barbato-Dosal A, Vadillo-Ortega F. Obesity increases metabolic syndrome risk factors in school-aged children from an urban school in Mexico city. J Am Diet Assoc. 2007 Jan; 107(1):81-91.

• Gomez Lopez NY, Estrada Gutierrez G, Beltran Montoya J, Vadillo Ortega F. Evaluacion de un microarreglo de anticuerpos en fase solida para el estudio de quimiocinas secretadas por la membrana corioamniotica. Ginecol Obstet Mex. 2006 Dec; 74(12):666-70.

• Meraz Cruz N, Beltran Montoya J, Estrada Gutierrez G, Vadillo Ortega F. Identificacion de la metaloproteasa de matriz extracelular-3 en la membrana fetal de la rata y su posible implicacion en la rotura de las membranas corioamnioticas. Ginecol Obstet Mex. 2006 Dec; 74(12):671-7.

• Martinez Flores A, Beltran Montoya J, Ortega Aguilar A, Vadillo Ortega F. Desarrollo y validacion de un modelo de cultivo in vitro para el estudio de la diferenciacion del trofoblasto humano. Ginecol Obstet Mex. 2006 Dec; 74(12):657-65.

• Meraz-Cruz N, Ortega A, Estrada-Gutierrez G, Flores A, Espejel A, Hernandez-Guerrero C, Vadillo-Ortega F. Identification of a calcium-dependent matrix metalloproteinase complex in rat chorioallantoid membranes during labour. Mol Hum Reprod. 2006 Oct; 12(10):633-41.

• Irineo-Cabrales AB, Zambada-Senties C, Garduno-Espinosa J, Mejia-Arreguin H, Vadillo-Ortega F, Osuna-Ramirez I. Construccion de una escala clinica-ultrasonografica para el diagnostico de coledocolitiasis. Revista de Gastroenterología de México. 2006 Jul-Sep; 71(3):279-87.

• Zaga-Clavellina V, Merchant-Larios H, Garcia-Lopez G, Maida-Claros R, Vadillo-Ortega F. Differential secretion of matrix metalloproteinase-2 and -9 after selective infection with group B streptococci in human fetal membranes. J Soc Gynecol Investig. 2006 May; 13(4):271-9.

• Zaga-Clavellina V, Lopez GG, Estrada-Gutierrez G, Martinez-Flores A, Maida-Claros R, Beltran-Montoya J, Vadillo-Ortega F. Incubation of human chorioamniotic membranes with Candida albicans induces differential synthesis and secretion of interleukin-1beta, interleukin-6, prostaglandin E, and 92 kDa type IV collagenase. Mycoses. 2006 Jan; 49(1):6-13.

• Arriaga-Pizano L, Jimenez-Zamudio L, Vadillo-Ortega F, Martinez-Flores A, Herrerias-Canedo T, Hernandez-Guerrero C. The predominant Th1 cytokine profile in maternal plasma of preeclamptic women is not reflected in the choriodecidual and fetal compartments. J Soc Gynecol Investig. 2005 Jul; 12(5):335-42.

• Casanueva E, Angulo ME, Goidberg S, Pfeffer F, Meza-Camacho C, Vadillo-Ortega F, Rothenberg SJ. Bases para estimar las necesidades de vitamina C en la gestacion. Gac Med Mex. 2005 Jul-Aug; 141(4):273-7.

• Estrada-Gutierrez G, Zaga V, Gonzalez-Jimenez MA, Beltran-Montoya J, Maida-Claros R, Giono-Cerezo S, Vadillo-Ortega F. Initial characterization of the microenvironment that regulates connective tissue degradation in amniochorion during normal human labor. Matrix Biol. 2005 Jun; 24(4):306-12.

• Casanueva E, Ripoll C, Tolentino M, Morales RM, Pfeffer F, Vilchis P, Vadillo-Ortega F. Vitamin C supplementation to prevent premature rupture of the chorioamniotic membranes: a randomized trial. Am J Clin Nutr. 2005 Apr; 81(4):859-63.

• Estrada Gutierrez G, Reyes Trejo R, Maida Claros R, Beltran Montoya J, Vadillo Ortega F. La interaccion de las celulas inmunologicas coriodeciduales con estreptococo del grupo B condiciona la degradacion del tejido conectivo del corioamnios. Ginecol Obstet Mex. 2005 Apr; 73(4):198-204.

• Vadillo-Ortega F, Estrada-Gutierrez G. Role of matrix metalloproteinases in preterm labour. BJOG. 2005 Mar; 112 Suppl :19-22.

• Vega Sanchez R, Estrada Gutierrez G, Cerbulo Vazquez A, Beltran Montoya J, Vadillo Ortega F. Caracterizacion del espacio coriodecidual como un microambiente rico en moleculas efectoras que inducen la rotura de las membranas corioamnioticas durante el trabajo de parto. Ginecol Obstet Mex. 2004 Dec; 72:593-601.

• Estrada Gutierrez G, Reyes Trejo R, Maida Claros R, Beltran Montoya J, Vadillo Ortega F. La interaccion de los linfocitos coriodeciduales con los estreptococos del grupo B degrada el tejido conectivo del corioamnios. Ginecol Obstet Mex. 2004 Dec; 72:611-8.

• Lopez-Bojorquez LN, Arechavaleta-Velasco F, Vadillo-Ortega F, Montes-Sanchez D, Ventura-Gallegos JL, Zentella-Dehesa A. NF-kappaB translocation and endothelial cell activation is potentiated by macrophage-released signals co-secreted with TNF-alpha and IL-1beta. Inflamm Res. 2004 Oct; 53(10):567-75.

• Zaga V, Estrada-Gutierrez G, Beltran-Montoya J, Maida-Claros R, Lopez-Vancell R, Vadillo-Ortega F. Secretions of interleukin-1beta and tumor necrosis factor alpha by whole fetal membranes depend on initial interactions of amnion or choriodecidua with lipopolysaccharides or group B streptococci. Biol Reprod. 2004 Oct; 71(4):1296-302.

• Vadillo Ortega F, Strauss JF, Perichart O, Buendia G, Ibarra I, Serrano M, Furusho R, Ahued R. L-arginine supplementation prevents preeclampsia in a high risk population. J Soc Gynecol Investig. 2004 FEB; 11:125A-125A.

• Vadillo Ortega F, Beltran Montoya J, Zaga Clavellina V. Intrauterine infection and preterm birth. Rev Invest Clin. 2004 JAN-FEB; 56:93-102.

• Vadillo-Ortega F, Beltran-Montoya J, Zaga-Clavellina V. Infeccion intrauterina y nacimiento pretermino. Rev Invest Clin. 2004 Jan-Feb; 56(1):93-102.

• Meraz Cruz MC, Beltran Montoya J, Bustos Lopez H, Flores Pliego A, Espejel A, Buendia Diaz G, Vadillo-Ortega F. Propiedades de la zona del corioamnios que inducen la rotura prematura de membranas. Ginecol Obstet Mex. 2003 Nov; 71:551-8.

• Hernandez-Guerrero C, Monzon-Bordonaba F, Jimenez-Zamudio L, Ahued-Ahued R, Arechavaleta-Velasco F, Strauss JF 3rd, Vadillo-Ortega F. In-vitro secretion of proinflammatory cytokines by human amniochorion carrying hyper-responsive gene polymorphisms of tumour necrosis factor-alpha and interleukin-1beta. Mol Hum Reprod. 2003 Oct; 9(10):625-9.

• Tejero E, Perichart O, Pfeffer F, Casanueva E, Vadillo-Ortega F. Collagen synthesis during pregnancy, vitamin C availability, and risk of premature rupture of fetal membranes. Int J Gynaecol Obstet. 2003 Apr; 81(1):29-34.

• Estrada-Bernal A, Mendoza-Milla C, Ventura-Gallegos JL, Lopez-Bojorquez LN, Miranda-Peralta E, Arechavaleta-Velasco F, Vadillo-Ortega F, Sanchez-Sanchez L, Zentella-Dehesa A. NF-kappaB dependent activation of human endothelial cells treated with soluble products derived from human lymphomas. Cancer Lett. 2003 Mar 10; 191(2):239-48.

• Meraz-Cruz N, Molina Delgado G, Vadillo-Ortega F. Cambios secuenciales de metaloproteinasas de matriz extracelular durante la gestacion y el trabajo de parto en el corioalantoides de la rata. Rev Invest Clin. 2003 Jan-Feb; 55(1):36-42.

• Monzon-Bordonaba F, Vadillo-Ortega F, Feinberg RF. Modulation of trophoblast function by tumor necrosis factor-alpha: a role in pregnancy establishment and maintenance?. Am J Obstet Gynecol. 2002 Dec; 187(6):1574-80.

• Arechavaleta-Velasco F, Ogando D, Parry S, Vadillo-Ortega F. Production of matrix metalloproteinase-9 in lipopolysaccharide-stimulated human amnion occurs through an autocrine and paracrine proinflammatory cytokine-dependent system. Biol Reprod. 2002 Dec; 67(6):1952-8.

• Hernandez Guerrero CA, Vadillo Ortega F, Tlapanco Barba R, Arriaga Pizano L, Cerbulo Vazquez A, Gonzalez Jimenez MA, Beltran Montoya J. Alteracion de la respuesta inmunologica sistemica en asociacion con endometriosis, empleando un modelo de estudio animal. Ginecol Obstet Mex. 2002 Apr; 70:171-81.

• Beltran Montoya J, Avila-Vergara MA, Vadillo-Ortega F, Hernandez-Guerrero C, Peraza-Garay F, Olivares-Morales S. Infeccion cervicovaginal como factor de riesgo para parto pretermino. Ginecol Obstet Mex. 2002 Apr; 70:203-9.

• Estrada Gutierrez Gdel C, Vadillo-Ortega F, Jimenez Gonzalez MA, Beltran Montoya J, Giono Cerezo S. Caracterizacion bioquimica y ultraestructural del efecto de la interleucina 1-beta como mediador de degradacion de tejido conectivo en membranas corioamnioticas humanas en cultivo. Ginecol Obstet Mex. 2002 Apr; 70:190-5.

• Arechavaleta-Velasco F, Mayon-Gonzalez J, Gonzalez-Jimenez M, Hernandez-Guerrero C, Vadillo-Ortega F. Association of type II apoptosis and 92-kDa type IV collagenase expression in human amniochorion in prematurely ruptured membranes with tumor necrosis factor receptor-1 expression. J Soc Gynecol Investig. 2002 Mar-Apr; 9(2):60-7.

• Vadillo-Ortega F, Sadowsky DW, Haluska GJ, Hernandez-Guerrero C, Guevara-Silva R, Gravett MG, Novy MJ. Identification of matrix metalloproteinase-9 in amniotic fluid and amniochorion in spontaneous labor and after experimental intrauterine infection or interleukin-1 beta infusion in pregnant rhesus monkeys. Am J Obstet Gynecol. 2002 Jan; 186(1):128-38.

• Pfeffer F, Tejero E, Perichart O, Casanueva E, Vadillo Ortega F. Collagen synthesis during gestation, ascorbic acid availability and risk of premature rupture of the amniotic membranes (PROM). FASEB Journal. 2001 MAR 8; 15:A965-A965.

• Arechavaleta-Velasco F, Hernandez-Guerrero C, Ahued-Ahued R, Vadillo-Ortega F. Evidence of endothelial cytotoxic compounds in placental extracts from preeclamptic women. J Soc Gynecol Investig. 2000 Mar-Apr; 7(2):114-7.

• Hernandez-Guerrero C, Tenorio-Ramos J, Vadillo-Ortega F, Arechavaleta-Velasco F, Jimenez-Zamudio L, Ahued-Ahued JR, Beltran-Montoya J, Neri-Mendez C. Factor de necrosis tumoral-alpha e interleucina-1 beta en los compartimentos intravascular materno, fetal y retroplacentario en parto a termino y pretermino. Ginecol Obstet Mex. 2000 Mar; 68:105-12.

• Vadillo Ortega F, Avila Vergara MA, Hernandez Guerrero C, Arechavaleta Velasco F, Beltran Montoya J. Apoptosis en trofoblasto de pacientes con aborto espontaneo recurrente de causa no identificada. Ginecol Obstet Mex. 2000 Mar; 68:122-31.

• Pfeffer F, Casanueva E, Kamar J, Guerra A, Perichart O, Vadillo-Ortega F. Modulation of 72-kilodalton type IV collagenase (Matrix metalloproteinase-2) by ascorbic acid in cultured human amnion-derived cells. Biol Reprod. 1998 Aug; 59(2):326-9.

• Mancilla-Ramirez J, Casanueva E, Vadillo-Ortega F, Pfeffer F, Tejero E, Ahued-Ahued JR, Arredondo-Garcia JL, Kunhardt-Rasch J, Rio de la Loza-Cava MF. Ruptura prematura de membranas y parto pretermino. Gac Med Mex. 1998 Jul-Aug; 134(4):423-41.

• Vadillo Ortega F, Arechevaleta F, Beltran Montoya J. Apoptosis y degradacion de matriz extracelular en corioamnios durante el trabajo de parto y en la ruptura prematura de membranas. Ginecol Obstet Mex. 1998 May; 66:202-7.

• Casanueva E, Vadillo Ortega F, Pfeffer F, Tejero E. Vitamin C and premature rupture of chorioamniotic membranes. Nutrition Research. 1998 FEB; 18:241-245.

• Bustos-Lopez HH, Baggish M, Valle RF, Vadillo-Ortega F, Ibarra V, Nava G. Assessment of the safety of intrauterine instillation of heated saline for endometrial ablation. Fertil Steril. 1998 Jan; 69(1):155-60.

• Gonzalez-Avila G, Iturria C, Vadillo-Ortega F, Ovalle C, Montano M. Changes in matrix metalloproteinases during the evolution of interstitial renal fibrosis in a rat experimental model. Pathobiology. 1998; 66(5):196-204.

• Bustos-Lopez HH, Ibarra-Chavarria V, Vadillo-Ortega F, Nava-Loya G, Baggish M, Valle RF. Ablacion endometrial por medio de calor liquido usando el sistema EnAbl, en pacientes sometidas a histerectomia abdominal. Estudio de seguridad. Ginecol Obstet Mex. 1997 May; 65:167-74.

• Beltran Montoya J, Meraz Cruz CN, Vadillo Ortega F. Identificacion de nexos moleculares entre infeccion y ruptura prematura de membranas. Ginecol Obstet Mex. 1997 May; 65:191-3.

• Bustos-Lopez HH, Ibarra-Chavarria V V, Vadillo-Ortega F, Nava-Loya G, Baggish MS, Valle RF. Endometrial Ablation with the EnAbl System. J Am Assoc Gynecol Laparosc. 1996 Aug; 3(4, Supplem):S5.

• Nava-Loya G, Hernandez-Guerrero C, Perez-Ocharan M, Mojarra-Estrada JM, Gonzalez-Morales ME, Bustos-Lopez H, Alvarado-Duran A, Vadillo-Ortega F. Respuesta inmune peritoneal en endometriosis. Ginecol Obstet Mex. 1996 Apr; 64:147-53.

• Vadillo-Ortega F, Hernandez A, Gonzalez-Avila G, Bermejo L, Iwata K, Strauss JF 3rd. Increased matrix metalloproteinase activity and reduced tissue inhibitor of metalloproteinases-1 levels in amniotic fluids from pregnancies complicated by premature rupture of membranes. Am J Obstet Gynecol. 1996 Apr; 174(4):1371-6.

• Villanueva-Diaz C, Arias-Martinez J, Bermejo-Martinez L, Vadillo-Ortega F. Progesterone induces human sperm chemotaxis. Fertil Steril. 1995 Dec; 64(6):1183-8.

• Gonzalez-Avila G, Ginebra M, Hayakawa T, Vadillo-Ortega F, Teran L, Selman M. Collagen metabolism in human aqueous humor from primary open-angle glaucoma. Decreased degradation and increased biosynthesis play a role in its pathogenesis. Arch Ophthalmol. 1995 Oct; 113(10):1319-23.

• Gonzalez-Avila G, Lozano D, Manjarrez ME, Ruiz VM, Teran L, Vadillo-Ortega F, Selman M. Influence on collagen metabolism of vitreous from eyes with proliferative vitreoretinopathy. Ophthalmology. 1995 Sep; 102(9):1400-5.

• Lei H, Vadillo-Ortega F, Paavola LG, Strauss JF 3rd. 92-kDa gelatinase (matrix metalloproteinase-9) is induced in rat amnion immediately prior to parturition. Biol Reprod. 1995 Aug; 53(2):339-44.

• Vadillo Ortega F, Pfeffer Burak F, Bermejo Martinez ML, Hernandez Miranda MA, Beltran Montoya J, Tejero Barrera E, Casanueva y Lopez E. Factores dieteticos y ruptura prematura de membranas. Efecto de la vitamina C en la degradacion de colagena en el corioamnios. Ginecol Obstet Mex. 1995 Apr; 63:158-62.

• Vadillo Ortega F, Hernandez Miranda A, Bermejo Martinez L, Beltran Montoya J, Gonzalez Avila G. Transicion de la forma enzimatica latente a activa como un modelo de regulacion de la degradacion de matriz extracelular en el corioamnios durante el trabajo de parto humano. Ginecol Obstet Mex. 1995 Apr; 63:166-72.

• Vadillo-Ortega F, Gonzalez-Avila G, Montfort I, Bermejo L, Perez-Tamayo R. Extraction and partial characterization of a low molecular weight collagenase from normal rat kidney. Arch Med Res. 1995 Autumn; 26(3):273-8.

• Vadillo-Ortega F, Gonzalez-Avila G, Furth EE, Lei H, Muschel RJ, Stetler-Stevenson WG, Strauss JF 3rd. 92-kd type IV collagenase (matrix metalloproteinase-9) activity in human amniochorion increases with labor. Am J Pathol. 1995 Jan; 146(1):148-56.

• Vadillo Ortega F, Villanueva Diaz C, Arias Martinez QB, Bermejo L, Bustos Lopez H. Factor quimiotactico para espermatozoides: una nueva funcion biologica de la progesterona. Ginecol Obstet Mex. 1994 May; 62:127-30.

• Vadillo Ortega F, Beltran J, Mateo H, Monzon F. Fosfolipasa A2 y ruptura prematura de membranas. Ginecol Obstet Mex. 1994 May; 62:143-5.

• Olivares S, Villanueva-Diaz C, Hernandez C, Arredondo JL, Vadillo-Ortega F. Identification and partial characterization of an immunoglobulin A protease associated with human sperm. Biol Reprod. 1993 Jul; 49(1):162-5.

• Alva Trujillo H, Bustos HH, Alvarado Duran A, Vadillo Ortega F. Cuantificacion de acido desoxirribonucleico y colagena como marcadores bioquimicos de leiomiomatosis uterina. Ginecol Obstet Mex. 1992 Sep; 60:263-6.

• Villanueva-Diaz C, Arias-Martinez J, Bustos-Lopez H, Vadillo-Ortega F. Novel model for study of human sperm chemotaxis. Fertil Steril. 1992 Aug; 58(2):392-5.

• Bustos Lopez HH, Luis Arredondo J, Villanueva Diaz C, Soto Martinez J, Arias Martinez J, Vadillo Ortega F. Determinacion de glucosa como indice pronostico de infeccion intraamniotica. Ginecol Obstet Mex. 1992 Mar; 60:61-6.

• Vadillo Ortega F, Hernandez A, Meraz Cruz N, Monzon Bordonaba FA, Beltran Montoya J, Soto Martinez J, Bustos Lopez H. Participacion de las metaloproteasas de matriz extracelular en la ruptura prematura de membranas fetales: un modelo fisiopatogenico novedoso. Ginecol Obstet Mex. 1992 Mar; 60:79-85.

• Olivares Morales S, Vadillo Ortega F, Villanueva Diaz C, Hernandez Guerrero C, Arredondo Garcia JL. Identificacion y caracterizacion inicial de una proteasa de inmunoglobulina A asociada a espermatozoides humanos. Ginecol Obstet Mex. 1992 Mar; 60:67-74.

• Vadillo-Ortega F, Gonzalez-Avila G, Villanueva-Diaz C, Banales JL, Selman-Lama M, Alvarado Duran A. Human amniotic fluid modulation of collagenase production in cultured fibroblasts. A model of fetal membrane rupture. Am J Obstet Gynecol. 1991 Feb; 164(2):664-8.

• Coutifaris C, Babalola GO, Abisogun AO, Kao LC, Chin U, Vadillo-Ortega F, Osheroff J, Kliman HJ, Strauss JF 3rd. In vitro systems for the study of human trophoblast implantation. Ann N Y Acad Sci. 1991; 622:191-201.

• Bustos-Lopez H, Hong E, Vadillo-Ortega F, Castaneda G, Karchmer S. Potentiation of vascular responses using placental extracts from eclamptic women. Proc West Pharmacol Soc. 1991; 34:189-93.

• Villanueva-Diaz C, Vadillo-Ortega F, Kably-Ambe A, Diaz-Perez MA, Krivitzky SK. Evidence that human follicular fluid contains a chemoattractant for spermatozoa. Fertil Steril. 1990 Dec; 54(6):1180-2.

• Vadillo-Ortega F, Gonzalez-Avila G, Karchmer S, Cruz NM, Ayala-Ruiz A, Lama MS. Collagen metabolism in premature rupture of amniotic membranes. Obstet Gynecol. 1990 Jan; 75(1):84-8.

• Vadillo-Ortega F, Gonzalez-Avila G, Chevez P, Abraham CR, Montano M, Selman-Lama M. A latent collagenase in human aqueous humor. Invest Ophthalmol Vis Sci. 1989 Feb; 30(2):332-5.

• Gonzalez-Avila G, Vadillo-Ortega F, Perez-Tamayo R. Experimental diffuse interstitial renal fibrosis. A biochemical approach. Lab Invest. 1988 Aug; 59(2):245-52.

Tesista de Doctorado

• Daniel Eduardo Sandoval Colín
• Sheyla Karina Hernández Ramírez

Tesista de Licenciatura

• María Aurora Ibarra López

Servicio Social

• Carmina Aurora Calva Esquivel
• Edwin Gerardo Ortíz Virgen
• María Fernanda Iturbe Mendoza
• Nelly Sarai Vizueth Bautista
• Reyna Itzel González Venancio
• Sebastián Malagón Serrano

Estancia Voluntaria

• Alma Lilia Hernández Olvera
• Ana Lorena Álvarez Ballesteros
• Andrea García Sepulveda
• Andrea Velázquez Trejo
• Ashley Gochar Mora
• David Oswaldo Valdez Mena
• Fernanda Giselle Rojas González
• Irving Conde Galicia
• Ishar Arad Retana Arellano
• Jesús Armando De la Rosa Arellano
• Kathya Paola Zarco Morales
• Katya Andrea López Jiménez
• Kimberley Ortega Gómez
• Ljubica Giselle Pérez González
• Nidia Areli Uvilla Amador
• Pamela Sandoval Montaño
• Ramsés Zuñiga Vera
• Ricardo Federico Hernández Franco
• Samantha Rodríguez Espinoza
• Santiago Alonso Escorcia
• Tania Gisselle Rodezno Antunes

En curso

• Análisis del transcriptoma de células mononucleares de individuos con respuestas extremas a la suplementación con aceite de pescado
• Caracterización de marcadores genéticos involucrados en la regulación neuroendócrina del apetito y adiposidad en pacientes con obesidad mórbida extrema
• Comparación del efecto de un extracto de cocoa vs polifenoles biotransformados sobre la expresión génica en células mononucleares y endoteliales.
• Identificación de mutaciones que confieren resistencia a los fármacos antituberculosis en muestra clínica y aislados de pacientes con tuberculosis pulmonar en la República Mexicana.
• Los elementos transponibles y los RNAs no codificantes cortos en la estabilidad genómica de la placenta como un mecanismo programador de la salud y la enfermedad
• Panel microbiológico de riesgo de parto pretérmino guiado por inteligencia computacional
• Perfil de expresión diferencial de microRNAs en plasma de adultos con síndrome metabólico. MODALIDAD: PROYECTO DE GRUPO
• Respuesta a la intervención con PUFAs de acuerdo a los genotipos de PPAR
• Una intervención multietápica dirigida a los primeros 1,000días de vida para contribuir a disminuir la obesidad infantil y sus comorbilidades

Terminados

• Análisis de la contribución de la adiposidad a lo largo del embarazo en la modificación de la flexibilidad metabólica
• Caracterización de cambios en mediadores inflamatorios asociados a modificaciones en la microbiota cervicovaginal a lo largo del embarazo y su relación con el nacimiento pretérmino.
• Caracterización del microbioma intestinal durante la semana 12 a 24 de gestación en mujeres que desarrollan diabetes gestacional.
• Efectos del estado de nutrición y exposición a factores ambientales durante el embarazo en el perfil del metiloma y perfil metabólomico del niño.
• Ensayo clínico de una huella metabolómica como herramientas diagnóstica temprana de diabetes gestacional.
• Estudio de los mecanismos epigenéticos que modulan la función placentaria y sus consecuencias en el crecimiento fetal
• Evaluación del desarrollo y crecimiento de la placenta humana y su correlación con el perfil de microRNAs circulantes
• Genómica del Nacimiento Pretérmino
• Identificación de cambios secuenciales en el transcriptoma del corioamnios durante la evolución del trabajo de parto humano normal y en el trabajo de parto pretérmino.
• Validación de un panel de biomarcadores para el diagnóstico temprano del inicio del trabajo de parto pretérmino o normal.