Cursó la licenciatura obteniendo el Título de Médico Cirujano en la Facultad de Medicina en la Universidad La Salle; obtuvo la Especialización en Genética Médica en el Departamento de Genética Humana del Instituto Nacional de Pediatría y el Doctorado en Biología Experimental en la Universidad Autónoma Metropolitana. Actualmente es Subdirectora del Investigación Básica, e Investigadora en Ciencias Médicas “D”, adscrita al laboratorio de Enfermedades Cardiovasculares del INMEGEN y miembro del Sistema Nacional de Investigadores (SNI) Nivel II.

En 2010 inició en las líneas de investigación Genómica de las Enfermedades Cardiovasculares, englobando proyectos dirigidos a la genómica de la enfermedad arterial coronaria, factores de riesgo cardiovascular y arritmias hereditarias entre otros temas.

Ha publicado 60 artículos de investigación en revistas internacionales y 4 capítulos de libro. Muchos de los resultados de las líneas mencionados se han publicado en revistas del más alto impacto, tales como Nature Communications, Human Mutation, Diabetes entre otras y cuenta con más de 850 citas. Ha dirigido 5 tesis, que incluyen 1 de doctorado, 2 de maestría, y 2 de licenciatura. Desde 2014 es profesora del Posgrado de Ciencias Médicas Odontológicas y de la Salud en la UNAM. Ha recibido 19 premios y distinciones.

Artículos

• Romero-Hidalgo S, Sagaceta-Mejia J, Villalobos-Comparan M, Tejero ME, Dominguez-Perez M, Jacobo-Albavera L, Posadas-Sanchez R, Vargas-Alarcon G, Posadas-Romero C, Macias-Kauffer L, Vadillo-Ortega F, Contreras-Sieck MA, Acuna-Alonzo V, Barquera R, Macin G, Binia A, Guevara-Chavez JG, Sebastian-Medina L, Menjivar M, Canizales-Quinteros S, Carnevale A, Villarreal-Molina T. Selection scan in Native Americans of Mexico identifies FADS2 rs174616: Evidence of gene-diet interactions affecting lipid levels and Delta-6-desaturase activity. Heliyon. 2024 Aug 15; 10(15):e35477.

• Gonzalez-Garrido A, Lopez-Ramirez O, Cerda-Mireles A, Navarrete-Miranda T, Flores-Arenas AI, Rojo-Dominguez A, Arregui L, Iturralde P, Antunez-Arguelles E, Dominguez-Perez M, Jacobo-Albavera L, Carnevale A, Villarreal-Molina T. KCNQ1 p.D446E Variant as a Risk Allele for Arrhythmogenic Phenotypes: Electrophysiological Characterization Reveals a Complex Phenotype Affecting the Slow Delayed Rectifier Potassium Current (IKs) Voltage Dependence by Causing a Hyperpolarizing Shift and a Lack of Response to Protein Kinase A Activation. Int J Mol Sci. 2024 Jan 12; 25(2):None.

• Moran-Ramos S, Cerqueda-Garcia D, Lopez-Contreras B, Larrieta-Carrasco E, Villamil-Ramirez H, Molina-Cruz S, Torres N, Sanchez-Tapia M, Hernandez-Pando R, Aguilar-Salinas C, Villarreal-Molina T, Canizales-Quinteros S. A metagenomic study identifies a Prevotella copri enriched microbial profile associated with non-alcoholic steatohepatitis in subjects with obesity. J Gastroenterol Hepatol. 2023 May; 38(5):791-799.

•  

  Villarreal-Molina T, Garcia-Ordonez GP, Reyes-Quintero AE, Dominguez-Perez M, Jacobo-Albavera L, Nava S, Carnevale A, Medeiros-Domingo A, Iturralde P. Clinical Spectrum of SCN5A Channelopathy in Children with Primary Electrical Disease and Structurally Normal Hearts. Genes (Basel). 2021 Dec 22; 13(1):.

• Salazar-Valencia IG, Villamil-Ramirez H, Barajas-Olmos F, Guevara-Cruz M, Macias-Kauffer LR, Garcia-Ortiz H, Hernandez-Vergara O, De Sandy-Galan DAD, Leon-Mimila P, Centeno-Cruz F, Gonzalez-Salazar LE, Guizar-Heredia R, Pichardo-Ontiveros E, Jacobo-Albavera L, Posadas-Sanchez R, Vargas-Alarcon G, Velazquez-Cruz R, Gutierrez-Aguilar R, Zerrweck C, Rocha-Gonzalez HI, Reyes-Garcia JG, Carrasco-Portugal MD, Flores-Murrieta FJ, Tovar AR, Orozco L, Villarreal-Molina T, Canizales-Quinteros S. Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions. Genes (Basel). 2022 DEC; 13(12):None.

• Gonzalez-Garrido A, Rosas-Madrigal S, Rojo-Dominguez A, Arellanes-Robledo J, Lopez-Mora E, Carnevale A, Arregui L, Rosendo-Gutierrez R, Romero-Hidalgo S, Villarreal-Molina MT. Leukocyte Nuclear Morphology Alterations in Dilated Cardiomyopathy Caused by a Lamin AC Truncating Mutation (LMNA/Ser431*) Are Modified by the Presence of a LAP2 Missense Polymorphism (TMPO/Arg690Cys). Int J Mol Sci. 2022 Nov 7; 23(21):.

• Lopez-Montoya P, Cerqueda-Garcia D, Rodriguez-Flores M, Lopez-Contreras B, Villamil-Ramirez H, Moran-Ramos S, Molina-Cruz S, Rivera-Paredez B, Antuna-Puente B, Velazquez-Cruz R, Villarreal-Molina T, Canizales-Quinteros S. Association of Gut Microbiota with Atherogenic Dyslipidemia, and Its Impact on Serum Lipid Levels after Bariatric Surgery. Nutrients. 2022 SEP; 14(17):None.

• Reyes P, Garcia-de Teresa B, Juarez U, Perez-Villatoro F, Fiesco-Roa MO, Rodriguez A, Molina B, Villarreal-Molina MT, Melendez-Zajgla J, Carnevale A, Torres L, Frias S. Fanconi Anemia Patients from an Indigenous Community in Mexico Carry a New Founder Pathogenic Variant in FANCG. Int J Mol Sci. 2022 Feb 20; 23(4):.

• Rosas-Madrigal S, Villarreal-Molina MT, Flores-Rivera J, Rivas-Alonso V, Macias-Kauffer LR, Ordonez G, Chima-Galan MDC, Acuna-Alonzo V, Macin-Perez G, Barquera R, Granados J, Valle-Rios R, Corona T, Carnevale A, Romero-Hidalgo S. Interaction of HLA Class II rs9272219 and TMPO rs17028450 (Arg690Cys) Variants Affects Neuromyelitis Optica Spectrum Disorder Susceptibility in an Admixed Mexican Population. Front Genet. 2021; 12:647343.

• Leon-Mimila P, Villamil-Ramirez H, Macias-Kauffer LR, Jacobo-Albavera L, Lopez-Contreras BE, Posadas-Sanchez R, Posadas-Romero C, Romero-Hidalgo S, Moran-Ramos S, Dominguez-Perez M, Olivares-Arevalo M, Lopez-Montoya P, Nieto-Guerra R, Acuna-Alonzo V, Macin-Perez G, Barquera-Lozano R, Del-Rio-Navarro BE, Gonzalez-Gonzalez I, Campos-Perez F, Gomez-Perez F, Valdes VJ, Sampieri A, Reyes-Garcia JG, Carrasco-Portugal MDC, Flores-Murrieta FJ, Aguilar-Salinas CA, Vargas-Alarcon G, Shih D, Meikle PJ, Calkin AC, Drew BG, Vaca L, Lusis AJ, Huertas-Vazquez A, Villarreal-Molina T, Canizales-Quinteros S. Genome-Wide Association Study Identifies a Functional SIDT2 Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2021 Jul 8; :ATVBAHA120315391.

• Medina-Leyte DJ, Zepeda-Garcia O, Dominguez-Perez M, Gonzalez-Garrido A, Villarreal-Molina T, Jacobo-Albavera L. Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches. Int J Mol Sci. 2021 Apr 8; 22(8):.

• Gonzalez-Garrido A, Dominguez-Perez M, Jacobo-Albavera L, Lopez-Ramirez O, Guevara-Chavez JG, Zepeda-Garcia O, Iturralde P, Carnevale A, Villarreal-Molina T. Compound Heterozygous KCNQ1 Mutations Causing Recessive Romano-Ward Syndrome: Functional Characterization by Mutant Co-expression. Front Cardiovasc Med. 2021; 8:625449.

• Jacobo-Albavera L, Dominguez-Perez M, Medina-Leyte DJ, Gonzalez-Garrido A, Villarreal-Molina T. The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease. Int J Mol Sci. 2021 Feb 5; 22(4):.

• Carnevale A, Rosas-Madrigal S, Rosendo-Gutierrez R, Lopez-Mora E, Romero-Hidalgo S, Avila-Vazzini N, Jacobo-Albavera L, Dominguez-Perez M, Vargas-Alarcon G, Perez-Villatoro F, Navarrete-Martinez JI, Villarreal-Molina MT. Genomic study of dilated cardiomyopathy in a group of Mexican patients using site-directed next generation sequencing. Mol Genet Genomic Med. 2020 Nov; 8(11):e1504.

• Romero-Hidalgo S, Flores-Rivera J, Rivas-Alonso V, Barquera R, Villarreal-Molina MT, Antuna-Puente B, Macias-Kauffer LR, Villalobos-Comparan M, Ortiz-Maldonado J, Yu N, Lebedeva TV, Alosco SM, Garcia-Rodriguez JD, Gonzalez-Torres C, Rosas-Madrigal S, Ordonez G, Guerrero-Camacho JL, Trevino-Frenk I, Escamilla-Tilch M, Garcia-Lechuga M, Tovar-Mendez VH, Pacheco-Ubaldo H, Acuna-Alonzo V, Bortolini MC, Gallo C, Bedoya G, Rothhammer F, Gonzalez-Jose R, Ruiz-Linares A, Canizales-Quinteros S, Yunis E, Granados J, Corona T. Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population. Sci Rep. 2020 Aug 13; 10(1):13706.

• Leon-Mimila P, Villamil-Ramirez H, Li XS, Shih DM, Hui ST, Ocampo-Medina E, Lopez-Contreras B, Moran-Ramos S, Olivares-Arevalo M, Grandini-Rosales P, Macias-Kauffer L, Gonzalez-Gonzalez I, Hernandez-Pando R, Gomez-Perez F, Campos-Perez F, Aguilar-Salinas C, Larrieta-Carrasco E, Villarreal-Molina T, Wang Z, Lusis AJ, Hazen SL, Huertas-Vazquez A, Canizales-Quinteros S. Trimethylamine N-Oxide levels are associated with NASH in obese subjects with type 2 diabetes. Diabetes Metab. 2020 Aug 10; :.

• Villarreal-mMolina MT, Rosas-Madrigal S, Lopez-Mora E, Calderon-Avila AL, Rodriguez-Zanella H, Romero-Hidalgo S, Rosendo-Gutierrez R, Carnevale A. Homozygous Fukutin Missense Mutation in Two Mexican Siblings with Dilated Cardiomyopathy. Rev Invest Clin. 2020 May 7; 73(5):None.

• Medina-Leyted D., Domínguez-Pérez M., Mercado del Río I., Villarreal Molina MT., Jacobo-Albavera L.. Use of Human Umbilical Vein Endothelial Cells (HUVEC) as a Model to Study Cardiovascular Disease: A Review. Am J Med Genet. 2020 MAY; 27(1):None.

• Herrera-Rodriguez DL, Totomoch-Serra A, Rosas-Madrigal S, Luna-Limon C, Marroquin-Ramirez D, Carnevale A, Rosendo-Gutierrez R, Villarreal-Molina MT, Marquez-Murillo MF. Genes frequently associated with sudden death in primary hypertrophic cardiomyopathy. Arch Cardiol Mex. 2020; 90(1):58-68.

• Chittoor G, Haack K, Balakrishnan P, Bizon C, Laston S, Best LG, MacCluer JW, North KE, Umans JG, Franceschini N, Prasad G, Macias-Kauffer L, Villarreal-Molina T, Bharadwaj D, Canizales-Quinteros S, Navas-Acien A, Cole SA, Voruganti VS. Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study. Sci Rep. 2019 Nov 29; 9(1):17899.

• Gallegos-Cortez A, Alonso-Ortiz N, Antunez-Arguellez E, Villarreal-Molina T, Totomoch-Serra A, Iturralde-Torres P, Marquez MF. Catecholaminergic polymorphic ventricular tachycardia due to de novo RyR2 mutation: recreational cycling as a trigger of lethal arrhythmias. Arch Med Sci. 2020; 16(2):466-470.

• Macias-Kauffer LR, Villamil-Ramirez H, Leon-Mimila P, Jacobo-Albavera L, Posadas-Romero C, Posadas-Sanchez R, Lopez-Contreras BE, Moran-Ramos S, Romero-Hidalgo S, Acuna-Alonzo V, Del-Rio-Navarro BE, Bortolini MC, Gallo C, Bedoya G, Rothhammer F, Gonzalez-Jose R, Ruiz-Linares A, Stephens CR, Velazquez-Cruz R, Fernandez Del Valle-Laisequilla C, Reyes-Garcia JG, Barranco Garduno LM, Carrasco-Portugal MDC, Flores-Murrieta FJ, Vargas-Alarcon G, Aguilar-Salinas CA, Villarreal-Molina T, Canizales-Quinteros S. Genetic contributors to serum uric acid levels in Mexicans and their effect on premature coronary artery disease. Int J Cardiol. 2019 Oct 1; 279:.

• Rivera-Paredez B, Macias-Kauffer L, Fernandez-Lopez JC, Villalobos-Comparan M, Martinez-Aguilar MM, de la Cruz-Montoya A, Ramirez-Salazar EG, Villamil-Ramirez H, Quiterio M, Ramirez-Palacios P, Romero-Hidalgo S, Villarreal-Molina MT, Denova-Gutierrez E, Flores YN, Canizales-Quinteros S, Salmeron J, Velazquez-Cruz R. Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans. Nutrients. 2019 Jun 14; 11(6):.

• Moran-Ramos S, Villarreal-Molina MT, Canizales-Quinteros S. Host Genetics, Diet, and Microbiome: The Role of AMY1. Trends Microbiol. 2019 May 2; 27:.

• Garcia-de Teresa B, Frias S, Molina B, Villarreal MT, Rodriguez A, Carnevale A, Lopez-Hernandez G, Vollbrechtshausen L, Olaya-Vargas A, Torres L. FANCC Dutch founder mutation in a Mennonite family from Tamaulipas, Mexico. Mol Genet Genomic Med. 2019 May 1; 7:e710.

• Posadas-Sanchez R, Roque-Ramirez B, Rodriguez-Perez JM, Perez-Hernandez N, Fragoso JM, Villarreal-Molina T, Coral-Vazquez R, Tejero-Barrera ME, Posadas-Romero C, Vargas-Alarcon G. Raet1e Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study. Mediators Inflamm. 2018; 2018:1847696.

• Leon-Mimila P, Villamil-Ramirez H, Lopez-Contreras BE, Moran-Ramos S, Macias-Kauffer LR, Acuna-Alonzo V, Del Rio-Navarro BE, Salmeron J, Velazquez-Cruz R, Villarreal-Molina T, Aguilar-Salinas CA, Canizales-Quinteros S. Low Salivary Amylase Gene (AMY1) Copy Number Is Associated with Obesity and Gut Prevotella Abundance in Mexican Children and Adults. Nutrients. 2018 Nov 1; 10(11):.

• Otero-Díaz B., Rodríguez-Flores M., Sánchez-Muñoz V., Monraz-Preciado F., Ordoñez-Ortega S., Becerril-Elias V., Baay-Guzmán G., Obando-Monge R., García-García E., Palacios-González B., Villarreal-Molina MT., Sierra-Salazar M., Antuna-Puente B.. Exercise Induces White Adipose Tissue Browning Across the Weight Spectrum in Humans. Frontiers in Physiology. 2018; 9(1781):None.

• Lopez-Contreras BE, Moran-Ramos S, Villarruel-Vazquez R, Macias-Kauffer L, Villamil-Ramirez H, Leon-Mimila P, Vega-Badillo J, Sanchez-Munoz F, Llanos-Moreno LE, Canizalez-Roman A, Del Rio-Navarro B, Ibarra-Gonzalez I, Vela-Amieva M, Villarreal-Molina T, Ochoa-Leyva A, Aguilar-Salinas CA, Canizales-Quinteros S. Composition of gut microbiota in obese and normal-weight Mexican school-age children and its association with metabolic traits. Pediatr Obes. 2018 Jun; 13(6):381-388.

• Romero-Hidalgo S, Ochoa-Leyva A, Garciarrubio A, Acuna-Alonzo V, Antunez-Arguelles E, Balcazar-Quintero M, Barquera-Lozano R, Carnevale A, Cornejo-Granados F, Fernandez-Lopez JC, Garcia-Herrera R, Garcia-Ortiz H, Granados-Silvestre A, Granados J, Guerrero-Romero F, Hernandez-Lemus E, Leon-Mimila P, Macin-Perez G, Martinez-Hernandez A, Menjivar M, Morett E, Orozco L, Ortiz-Lopez G, Perez-Villatoro F, Rivera-Morales J, Riveros-McKay F, Villalobos-Comparan M, Villamil-Ramirez H, Villarreal-Molina T, Canizales-Quinteros S, Soberon X. Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing. Nat Commun. 2017 Oct 18; 8(1):1005.

• Monroy-Munoz IE, Angeles-Martinez J, Posadas-Sanchez R, Villarreal-Molina T, Alvarez-Leon E, Flores-Dominguez C, Cardoso-Saldana G, Medina-Urrutia A, Juarez-Rojas JG, Posadas-Romero C, Alarcon GV. PLA2G2A polymorphisms are associated with metabolic syndrome and type 2 diabetes mellitus. Results from the genetics of atherosclerotic disease Mexican study. Immunobiology. 2017 Sep 3; oct:.

• Moran-Ramos S, Ocampo-Medina E, Gutierrez-Aguilar R, Macias-Kauffer L, Villamil-Ramirez H, Lopez-Contreras BE, Leon-Mimila P, Vega-Badillo J, Gutierrez-Vidal R, Villarruel-Vazquez R, Serrano-Carbajal E, Del-Rio-Navarro BE, Huertas-Vazquez A, Villarreal-Molina T, Ibarra-Gonzalez I, Vela-Amieva M, Aguilar-Salinas CA, Canizales-Quinteros S. An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children. Sci Rep. 2017 Jul 17; 7(1):5607.

• Antunez-Arguelles E, Rojo-Dominguez A, Arregui-Mena AL, Jacobo-Albavera L, Marquez MF, Iturralde-Torres P, Villarreal-Molina MT. Compound heterozygous KCNQ1 mutations (A300T/P535T) in a child with sudden unexplained death: Insights into possible molecular mechanisms based on protein modeling. Gene. 2017 Jun 06; :.

• Villalobos-Comparan M, Antuna-Puente B, Villarreal-Molina MT, Canizales-Quinteros S, Velazquez-Cruz R, Leon-Mimila P, Villamil-Ramirez H, Gonzalez-Barrios JA, Merino-Garcia JL, Thompson-Bonilla MR, Jarquin D, Sanchez-Hernandez OE, Rodriguez-Arellano ME, Posadas-Romero C, Vargas-Alarcon G, Campos-Perez F, Quiterio M, Salmeron-Castro J, Carnevale A, Romero-Hidalgo S. Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population. BMC Med Genet. 2017 May 02; 18(1):46.

• Posadas-Sanchez R, Perez-Hernandez N, Rodriguez-Perez JM, Coral-Vazquez RM, Roque-Ramirez B, Llorente L, Lima G, Flores-Dominguez C, Villarreal-Molina T, Posadas-Romero C, Vargas-Alarcon G. Interleukin-27 polymorphisms are associated with premature coronary artery disease and metabolic parameters in the Mexican population: the genetics of atherosclerotic disease (GEA) Mexican study. Oncotarget. 2017 Sep 8; 8(38):64459-64470.

• Posadas-Sanchez R, Perez-Hernandez N, Angeles-Martinez J, Lopez-Bautista F, Villarreal-Molina T, Rodriguez-Perez JM, Fragoso JM, Posadas-Romero C, Vargas-Alarcon G. Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study. Mediators Inflamm. 2017; 2017:6012795.

• Angeles-Martinez J, Posadas-Sanchez R, Llorente L, Alvarez-Leon E, Ramirez-Bello J, Villarreal-Molina T, Lima G, Cardoso-Saldana G, Rodriguez-Perez JM, Perez-Hernandez N, Fragoso JM, Posadas-Romero C, Vargas-Alarcon G. The rs7044343 Polymorphism of the Interleukin 33 Gene Is Associated with Decreased Risk of Developing Premature Coronary Artery Disease and Central Obesity, and Could Be Involved in Regulating the Production of IL-33. PLoS One. 2017; 12(1):e0168828.

• Posadas-Sanchez R, Angeles-Martinez J, Perez-Hernandez N, Rodriguez-Perez JM, Lopez-Bautista F, Villarreal-Molina T, Fragoso JM, Posadas-Romero C, Vargas-Alarcon G. Receptor-interacting protein 2 (RIP2) gene polymorphisms are associated with increased risk of subclinical atherosclerosis and clinical and metabolic parameters. The Genetics of Atherosclerotic Disease (GEA) Mexican study. Exp Mol Pathol. 2016 Dec 07; 102(1):1-6.

• Villamil-Ramirez H, Leon-Mimila P, Macias-Kauffer LR, Canizalez-Roman A, Villalobos-Comparan M, Leon-Sicairos N, Vega-Badillo J, Sanchez-Munoz F, Lopez-Contreras B, Moran-Ramos S, Villarreal-Molina T, Zurita LC, Campos-Perez F, Huertas-Vazquez A, Bojalil R, Romero-Hidalgo S, Aguilar-Salinas CA, Canizales-Quinteros S. A combined linkage and association strategy identifies a variant near the GSTP1 gene associated with BMI in the Mexican population. J Hum Genet. 2016 Nov 24; :.

• Vega-Badillo J, Gutierrez-Vidal R, Hernandez-Perez HA, Villamil-Ramirez H, Leon-Mimila P, Sanchez-Munoz F, Moran-Ramos S, Larrieta-Carrasco E, Fernandez-Silva I, Mendez-Sanchez N, Tovar AR, Campos-Perez F, Villarreal-Molina T, Hernandez-Pando R, Aguilar-Salinas CA, Canizales-Quinteros S. Hepatic miR-33a/miR-144 and their target gene ABCA1 are associated with steatohepatitis in morbidly obese subjects. Liver Int. 2016 Mar 4; :.

• Posadas-Sanchez R, Posadas-Romero C, Cardoso-Saldana G, Vargas-Alarcon G, Villarreal-Molina MT, Perez-Hernandez N, Rodriguez-Perez JM, Medina-Urrutia A, Jorge-Galarza E, Juarez-Rojas JG, Torres-Tamayo M. Serum magnesium is inversely associated with coronary artery calcification in the Genetics of Atherosclerotic Disease (GEA) study. Nutr J. 2016; 15(1):22.

• Jacobo-Albavera L, Posadas-Romero C, Vargas-Alarcon G, Romero-Hidalgo S, Posadas-Sanchez R, Gonzalez-Salazar MD, Carnevale A, Canizales-Quinteros S, Medina-Urrutia A, Antunez-Arguelles E, Villarreal-Molina T. Dietary fat and carbohydrate modulate the effect of the ATP-binding cassette A1 () R230C variant on metabolic risk parameters in premenopausal women from the Genetics of Atherosclerotic Disease (GEA) Study. Nutr Metab (Lond). 2015; 12:45.

• Gutierrez-Vidal R, Vega-Badillo J, Reyes-Fermin LM, Hernandez-Perez HA, Sanchez-Munoz F, Lopez-Alvarez GS, Larrieta-Carrasco E, Fernandez-Silva I, Mendez-Sanchez N, Tovar AR, Villamil-Ramirez H, Mejia-Dominguez AM, Villarreal-Molina T, Hernandez-Pando R, Campos-Perez F, Aguilar-Salinas CA, Canizales-Quinteros S. SFRP5 hepatic expression is associated with non-alcoholic liver disease in morbidly obese women. Ann Hepatol. 2015 Sep-Oct; 14(5):666-74.

• Angeles-Martinez J, Posadas-Sanchez R, Alvarez-Leon E, Villarreal-Molina T, Cardoso-Saldana G, Fragoso JM, Juarez-Rojas JG, Medina-Urrutia A, Posadas-Romero C, Vargas-Alarcon G. Monocyte chemoattractant protein-1 gene (MCP-1) polymorphisms are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study. Immunol Lett. 2015 Aug 12; 167(2):125-130.

• Medina-Urrutia A, Posadas-Romero C, Posadas-Sanchez R, Jorge-Galarza E, Villarreal-Molina T, Gonzalez-Salazar Mdel C, Cardoso-Saldana G, Vargas-Alarcon G, Torres-Tamayo M, Juarez-Rojas JG. Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance. Cardiovasc Diabetol. 2015; 14:20.

• Vargas-Alarcon G, Angeles-Martinez J, Villarreal-Molina T, Alvarez-Leon E, Posadas-Sanchez R, Cardoso-Saldana G, Ramirez-Bello J, Perez-Hernandez N, Juarez-Rojas JG, Rodriguez-Perez JM, Fragoso JM, Posadas-Romero C. Interleukin-17A gene haplotypes are associated with risk of premature coronary artery disease in Mexican patients from the Genetics of Atherosclerotic Disease (GEA) study. PLoS One. 2015; 10(1):e0114943.

• Posadas-Sanchez R, Ocampo-Arcos WA, Lopez-Uribe AR, Posadas-Romero C, Villarreal-Molina T, Leon EA, Perez-Hernandez N, Rodriguez-Perez JM, Cardoso-Saldana G, Medina-Urrutia A, Vargas-Alarcon G. Hepatic lipase (LIPC) C-514T gene polymorphism is associated with cardiometabolic parameters and cardiovascular risk factors but not with fatty liver in Mexican population. Exp Mol Pathol. 2015 Feb; 98(1):93-8.

• Velazquez-Cruz R, Jimenez-Ortega RF, Parra-Torres AY, Castillejos-Lopez M, Patino N, Quiterio M, Villarreal-Molina T, Salmeron J. Analysis of association of MEF2C, SOST and JAG1 genes with bone mineral density in Mexican-Mestizo postmenopausal women.. BMC Musculoskelet Disord. 2014 Nov 28; 15:400.

• Gonzalez-Melchor L, Villarreal-Molina T, Iturralde-Torres P, Medeiros-Domingo A. Muerte subita cardiaca en el corazon estructuralmente normal: una actualizacion. Arch Cardiol Mex. 2014 Aug 12; 84(4):293-304.

• Vargas-Alarcon G, Posadas-Romero C, Villarreal-Molina T, Alvarez-Leon E, Angeles-Martinez J, Soto ME, Monroy-Munoz I, Juarez JG, Sanchez-Ramirez CJ, Ramirez-Bello J, Ramirez-Fuentes S, Fragoso JM, Rodriguez-Perez JM. The (G>A) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population: The Genetics of Atherosclerotic Disease Mexican Study. Biomed Res Int. 2014; 2014:931361.

• Lopez-Reyes A, Rodriguez-Perez JM, Fernandez-Torres J, Martinez-Rodriguez N, Perez-Hernandez N, Fuentes-Gomez AJ, Aguilar-Gonzalez CA, Alvarez-Leon E, Posadas-Romero C, Villarreal-Molina T, Pineda C, Vargas-Alarcon G. The HIF1A rs2057482 polymorphism is associated with risk of developing premature coronary artery disease and with some metabolic and cardiovascular risk factors. The Genetics of Atherosclerotic Disease (GEA) Mexican Study. Exp Mol Pathol. 2014 Apr 24; 96(3):405-410.

• Posadas-Sanchez R, Posadas-Romero C, Ocampo-Arcos WA, Villarreal-Molina MT, Vargas-Alarcon G, Antunez-Arguelles E, Mendoza-Perez E, Cardoso-Saldana G, Martinez-Alvarado R, Medina-Urrutia A, Jorge-Galarza E. Premature and severe cardiovascular disease in a Mexican male with markedly low high-density-lipoprotein-cholesterol levels and a mutation in the lecithin:cholesterol acyltransferase gene: A family study. Int J Mol Med. 2014 Jun; 33(6):1570-6.

• Larrieta-Carrasco E, Acuna-Alonzo V, Velazquez-Cruz R, Barquera-Lozano R, Leon-Mimila P, Villamil-Ramirez H, Menjivar M, Romero-Hidalgo S, Mendez-Sanchez N, Cardenas V, Banuelos-Moreno M, Flores YN, Quiterio M, Salmeron J, Sanchez-Munoz F, Villarreal-Molina T, Aguilar-Salinas CA, Canizales-Quinteros S. PNPLA3 I148M polymorphism is associated with elevated alanine transaminase levels in Mexican Indigenous and Mestizo populations. Mol Biol Rep. 2014 Apr 2; 41(7):4705-11.

• Velazquez-Cruz R, Garcia-Ortiz H, Castillejos-Lopez M, Quiterio M, Valdes-Flores M, Orozco L, Villarreal-Molina T, Salmeron J. WNT3A gene polymorphisms are associated with bone mineral density variation in postmenopausal mestizo women of an urban Mexican population: findings of a pathway-based high-density single nucleotide screening. Age (Dordr). 2014 Mar 3; 36(3):9635.

• Vargas-Alarcon G, Posadas-Romero C, Villarreal-Molina T, Alvarez-Leon E, Angeles-Martinez J, Posadas-Sanchez R, Monroy-Munoz I, Luna-Fuentes S, Gonzalez-Salazar C, Ramirez-Bello J, Cardoso-Saldana G, Medina-Urrutia A, Kimura-Hayama E. IL-24 Gene Polymorphisms Are Associated with Cardiometabolic Parameters and Cardiovascular Risk Factors But Not with Premature Coronary Artery Disease: The Genetics of Atherosclerotic Disease Mexican Study. J Interferon Cytokine Res. 2014 Feb 19; 34(9):659-66.

• Vargas-Alarcon G, Posadas-Romero C, Villarreal-Molina T, Alvarez-Leon E, Angeles J, Vallejo M, Posadas-Sanchez R, Cardoso G, Medina-Urrutia A, Kimura-Hayama E. Correction: Single Nucleotide Polymorphisms within (Lysosomal Acid Lipase A) Gene Are Associated with Susceptibility to Premature Coronary Artery Disease. A Replication in the Genetic of Atherosclerotic Disease (GEA) Mexican Study. PLoS One. 2013; 8(12):.

• Garcia-Velazquez LE, Canizales-Quinteros S, Romero-Hidalgo S, Ochoa-Morales A, Martinez-Ruano L, Marquez-Luna C, Acuna-Alonzo V, Villarreal-Molina MT, Alonso-Vilatela ME, Yescas-Gomez P. Founder effect and ancestral origin of the spinocerebellar ataxia type 7 (SCA7) mutation in Mexican families. Neurogenetics. 2013 Dec 28; 15(1):13-7.

• Vargas-Alarcon G, Posadas-Romero C, Villarreal-Molina T, Alvarez-Leon E, Angeles J, Vallejo M, Posadas-Sanchez R, Cardoso G, Medina-Urrutia A, Kimura-Hayama E. Single Nucleotide Polymorphisms within LIPA (Lysosomal Acid Lipase A) Gene Are Associated with Susceptibility to Premature Coronary Artery Disease. A Replication in the Genetic of Atherosclerotic Disease (GEA) Mexican Study. PLoS One. 2013; 8(9):e74703.

• Leon-Mimila P, Villamil-Ramirez H, Villalobos-Comparan M, Villarreal-Molina T, Romero-Hidalgo S, Lopez-Contreras B, Gutierrez-Vidal R, Vega-Badillo J, Jacobo-Albavera L, Posadas-Romeros C, Canizalez-Roman A, Rio-Navarro BD, Campos-Perez F, Acuna-Alonzo V, Aguilar-Salinas C, Canizales-Quinteros S. Contribution of common genetic variants to obesity and obesity-related traits in mexican children and adults. PLoS One. 2013; 8(8):e70640.

• Martinez-Rodriguez N, Posadas-Romero C, Villarreal-Molina T, Vallejo M, Del-Valle-Mondragon L, Ramirez-Bello J, Valladares A, Cruz-Lopez M, Vargas-Alarcon G. Single Nucleotide Polymorphisms of the Angiotensin-Converting Enzyme (ACE) Gene Are Associated with Essential Hypertension and Increased ACE Enzyme Levels in Mexican Individuals. PLoS One. 2013; 8(5):e65700.

• Larrieta-Carrasco E, Leon-Mimila P, Villarreal-Molina T, Villamil-Ramirez H, Romero-Hidalgo S, Jacobo-Albavera L, Gutierrez-Vidal R, Lopez-Contreras BE, Guillen-Pineda LE, Sanchez-Munoz F, Bojalil R, Mejia-Dominguez AM, Mendez-Sanchez N, Dominguez-Lopez A, Aguilar-Salinas CA, Canizales-Quinteros S. Association of the I148M/PNPLA3 Variant with Elevated Alanine Transaminase Levels in Normal-weight and Overweight/Obese Mexican Children. Gene. 2013 Mar 16; 520(2):185-8.

• Jacobo-Albavera L, Aguayo-de la Rosa PI, Maria Teresa Villareal Molina, Villamil-Ramirez H, Leon-Mimila P, Sandra Romero Hidalgo, Lopez-Contreras BE, Sanchez-Munoz F, Bojalil R, Gonzalez-Barrios JA, Aguilar-Salinas CA, Canizales-Quinteros S. VNN1 gene expression levels and the G-137T polymorphism are associated with HDL-C levels in Mexican prepubertal children.. PLoS One. 2012; 7(11):e49818.

•  

  Maria Teresa Villareal Molina, Posadas-Romero C, Sandra Romero Hidalgo, Antunez-Arguelles E, Bautista-Grande A, Vargas-Alarcon G, Kimura-Hayama E, Canizales-Quinteros S, Juarez-Rojas JG, Posadas-Sanchez R, Cardoso-Saldana G, Medina-Urrutia A, Gonzalez-Salazar Mdel C, Martinez-Alvarado R, Jorge-Galarza E, Alessandra Carnevale. The ABCA1 gene R230C variant is associated with decreased risk of premature coronary artery disease: the genetics of atherosclerotic disease (GEA) study.. PLoS One. 2012; 7(11):e49285.

• Villalobos-Comparan M, Villamil-Ramirez H, Maria Teresa Villareal Molina, Larrieta-Carrasco E, Leon-Mimila P, Sandra Romero Hidalgo, Jacobo-Albavera L, Liceaga-Fuentes AE, Campos-Perez FJ, Lopez-Contreras BE, Tusie-Luna T, Del Rio-Navarro BE, Aguilar-Salinas CA, Canizales-Quinteros S. PCSK1 rs6232 is associated with childhood and adult class III obesity in the Mexican population.. PLoS One. 2012; 7(6):e39037.

• Hunemeier T, Amorim CE, Azevedo S, Contini V, Acuna-Alonzo V, Rothhammer F, Dugoujon JM, Mazieres S, Barrantes R, Maria Teresa Villareal Molina, Paixao-Cortes VR, Salzano FM, Canizales-Quinteros S, Ruiz-Linares A, Bortolini MC. Evolutionary responses to a constructed niche: ancient Mesoamericans as a model of gene-culture coevolution.. PLoS One. 2012; 7(6):e38862.

• Romero-Hidalgo S, Villarreal-Molina T, Gonzalez-Barrios JA, Canizales-Quinteros S, Rodriguez-Arellano ME, Yanez-Velazco LB, Bernal-Alcantara DA, Villa AR, Antuna-Puente B, Acuna-Alonzo V, Merino-Garcia JL, Moreno-Sandoval HN, Carnevale A. Carbohydrate intake modulates the effect of the ABCA1-R230C variant on HDL cholesterol concentrations in premenopausal women. J Nutr. 2012 Feb; 142(2):278-83.

• Flores-Dorantes T, Arellano-Campos O, Posadas-Sanchez R, Villarreal-Molina T, Medina-Urrutia A, Romero-Hidalgo S, Yescas-Gomez P, Perez-Mendez O, Jorge-Galarza E, Tusie-Luna T, Villalobos-Comparan M, Jacobo-Albavera L, Villamil-Ramirez H, Lopez-Contreras BE, Aguilar-Salinas CA, Posadas-Romero C, Canizales-Quinteros S. Association of R230C ABCA1 gene variant with low HDL-C levels and abnormal HDL subclass distribution in Mexican school-aged children. Clin Chim Acta. 2010 Sep 6; 411(17-18):1214-7.

• Acuna-Alonzo V, Flores-Dorantes T, Kruit JK, Villarreal-Molina T, Arellano-Campos O, Hunemeier T, Moreno-Estrada A, Ortiz-Lopez MG, Villamil-Ramirez H, Leon-Mimila P, Villalobos-Comparan M, Jacobo-Albavera L, Ramirez-Jimenez S, Sikora M, Zhang LH, Pape TD, Granados-Silvestre Mde A, Montufar-Robles I, Tito-Alvarez AM, Zurita-Salinas C, Bustos-Arriaga J, Cedillo-Barron L, Gomez-Trejo C, Barquera-Lozano R, Vieira-Filho JP, Granados J, Romero-Hidalgo S, Huertas-Vazquez A, Gonzalez-Martin A, Gorostiza A, Bonatto SL, Rodriguez-Cruz M, Wang L, Tusie-Luna T, Aguilar-Salinas CA, Lisker R, Moises RS, Menjivar M, Salzano FM, Knowler WC, Bortolini MC, Hayden MR, Baier LJ, Canizales-Quinteros S. A functional ABCA1 gene variant is associated with low HDL-cholesterol levels and shows evidence of positive selection in Native Americans. Hum Mol Genet. 2010 Jul 15; 19(14):2877-85.

• Aguilar-Salinas CA, Canizales-Quinteros S, Rojas-Martinez R, Mehta R, Villarreal-Molina MT, Arellano-Campos O, Riba L, Gomez-Perez FJ, Tusie-Luna MT. Hypoalphalipoproteinemia in populations of Native American ancestry: an opportunity to assess the interaction of genes and the environment. Curr Opin Lipidol. 2009 Apr; 20(2):92-7.

• Canto P, Canto-Cetina T, Juarez-Velazquez R, Rosas-Vargas H, Rangel-Villalobos H, Canizales-Quinteros S, Velazquez-Wong AC, Villarreal-Molina MT, Fernandez G, Coral-Vazquez R. Methylenetetrahydrofolate reductase C677T and glutathione S-transferase P1 A313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women. Hypertens Res. 2008 May; 31(5):1015-9.

• Villarreal-Molina MT, Flores-Dorantes MT, Arellano-Campos O, Villalobos-Comparan M, Rodriguez-Cruz M, Miliar-Garcia A, Huertas-Vazquez A, Menjivar M, Romero-Hidalgo S, Wacher NH, Tusie-Luna MT, Cruz M, Aguilar-Salinas CA, Canizales-Quinteros S. Association of the ATP-binding cassette transporter A1 R230C variant with early-onset type 2 diabetes in a Mexican population. Diabetes. 2008 Feb; 57(2):509-13.

• Salinas CA, Cruz-Bautista I, Mehta R, Villarreal-Molina MT, Perez FJ, Tusie-Luna MT, Canizales-Quinteros S. The ATP-binding cassette transporter subfamily A member 1 (ABC-A1) and type 2 diabetes: an association beyond HDL cholesterol. Curr Diabetes Rev. 2007 Nov; 3(4):264-7.

• Villarreal-Molina MT, Aguilar-Salinas CA, Rodriguez-Cruz M, Riano D, Villalobos-Comparan M, Coral-Vazquez R, Menjivar M, Yescas-Gomez P, Konigsoerg-Fainstein M, Romero-Hidalgo S, Tusie-Luna MT, Canizales-Quinteros S. The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities. Diabetes. 2007 Jul; 56(7):1881-7.

• Canizales-Quinteros S, Aguilar-Salinas CA, Ortiz-Lopez MG, Rodriguez-Cruz M, Villarreal-Molina MT, Coral-Vazquez R, Huertas-Vazquez A, Hernandez-Caballero A, Lopez-Alarcon M, Brito-Zurita OR, Dominguez-Banda A, Martinez-Sanchez LR, Canto-de Cetina T, Vilchis-Dorantes G, Rosas-Vargas H, Granados-Silvestre MA, Medeiros-Domingo A, Menjivar M, Tusie-Luna MT. Association of PPARG2 Pro12Ala variant with larger body mass index in Mestizo and Amerindian populations of Mexico. Hum Biol. 2007 Feb; 79(1):111-9.

• Navalon-Garcia K, Mendoza-Alcantar L, Diaz-Vargas ME, Martinez-Godinez MA, Reyna-Garfias H, Aguilar-Salinas CA, Riba L, Canizales-Quinteros S, Villarreal-Molina T, Gonzalez-Chavez A, Argueta-Villamar V, Tusie-Luna MT, Miliar-Garcia A. HNF-1alpha G574S is a functional variant with decreased transactivation activity. Diabet Med. 2006 Dec; 23(12):1295-300.

• Yescas P, Huertas-Vazquez A, Villarreal-Molina MT, Rasmussen A, Tusie-Luna MT, Lopez M, Canizales-Quinteros S, Alonso ME. Founder effect for the Ala431Glu mutation of the presenilin 1 gene causing early-onset Alzheimer's disease in Mexican families. Neurogenetics. 2006 Jul; 7(3):195-200.

Tesista de Doctorado

• Daniela Sánchez Estrada
• Erika Vanessa Molina Murillo

En curso

• Búsqueda de blancos farmacológicos para la prevención de la enfermedad arterial coronaria en mexicanos mediante estudios de aleatorización mendeliana.
• Cambios en la expresión génica relacionados con técnicas que contribuyen a reducir el estrés y mejorar la calidad de vida
• Caracterización molecular de las mutaciones identificadas en genes asociados a cardiomiopatía dilatada e hipertrófica en pacientes mexicanos
• Efecto Funcional del gen ABCA1 sobre la formación de micropartículas endoteliales in vitro en condiciones basales y en respuesta a estímulos involucrados en la fisiopatología de la aterosclerosis.
• Estudio del perfil de expresión de miRNAs de vesículas extracelulares y mecanismos moleculares involucrados en el desarrollo de la aterosclerosis
• ESTUDIO DE MICROPARTÍCULAS ENDOTELIALES COMO POSIBLES BIOMARCADORES DE ENFERMEDAD ARTERIAL CORONARIA Y SU RELACIÓN CON VARIANTES GENÉTICAS DE ABCA1 EN POBLACIÓN MEXICANA
• Mecanismos moleculares de las canalopatías arritmogéncias cardiacas

Terminados

• Caracterización de las mutaciones en los genes FANC, en un grupo de pacientes con Anemia de Fanconi y su correlación con el potencial proliferativo de las células troncales hematopoyéticas
• Comparación de los niveles circulantes de Irisina antes y después del ejercicio en sujetos con diferentes IMC
• Detección de Nuevos Genes Implicados en la Muerte Súbita Inexplicada por Medio de la Secuenciación del Exoma
• Estudio Clínico y Genómico de la Insuficiencia Cardiaca, Arritmias y la Muerte Súbita, Causadas por Cardiomiopatías y Canalopatías Arritmogénicas en Pacientes Mexicanos.
• “Estudio Clínico y Genómico de la Insuficiencia Cardiaca, Arritmias y la Muerte Súbita, Causadas por Cardiomiopatías y Canalopatías Arritmogénicas en Pacientes Mexicanos.” Segunda Etapa.
• Estudio Clínico y Genómico de la Insuficiencia Cardiaca, Arritmias y la Muerte Súbita Causadas por Cardiomiopatías y Canalopatías Arritmogénicas en Pacientes Mexicanos. Tercera Etapa
• EVALUACIÓN DEL EFECTO DEL POLIMORFISMO R230C/ABCA1 EN LA FUNCIÓN ANTI-INFLAMATORIA Y EN LA MIGRACION DE MACROFAGOS
• Identificación de genes diferencialmente metilados en individuos con enferemedad arterial coronaria prematura, aterosclerosis subclínica y controles sanos
• Identificación de Marcadores Genéticos Asociados a Rasgos Metabólicos en Población Indígena Mexicana a través del Escrutinio Completo del Genoma
• Identificación de Variantes Genéticas que Confieren Susceptibilidad a la Enfermedad Arterial Coronaria en Población Mexicana
• Identificación y caracterización clínica y molecular de la Cardiomiopatía Dilatada Familiar en pacientes mexicanos
• Papel de la proteína ABCA1 y su variación genética en la enfermedad por VIH
• TECNOLOGÍA PAR EL SEGUIMIENTO DE PACIENTES CON DIABETES MELLITUS DE ORIGEN MAYA UTILIZANDO MARCADORES GENÉTICOS DEL EXOMA
• Tecnología, Seguimiento y Respuesta a Metformina de Diabéticos con Datos Genómicos y Metagenómicos
• Validación de Teconología para el Seguimiento de Pacientes de Ascendencia Maya con Diabetes Usando Marcadores Genéticos.
• VARIACIÓN GENÉTICA COMÚN ASOCIADA A ENFERMEDAD ARTERIAL CORONARIA PREMATURA EN POBLACIÓN MEXICANA Y ANÁLISIS DE INTERACCIONES GEN AMBIENTE