Curriculum Vitae

Dr. Humberto García Ortiz

Dr. Humberto García Ortiz

Investigador en Ciencias Médicas D
5350-1962 ext.1962
hgarcia@inmegen.gob.mx

Cursó la licenciatura en Química Farmacéutica Biológica en la Universidad Autónoma Metropolitana unidad Xochimilco; obtuvo el grado de Doctor en Ciencias Biomédicas con mención honorifica en la Facultad de Ciencias Biomédicas de la Universidad Nacional Autónoma de México, ha realizado diversas estancias de investigación, resaltando las hechas en el instituto BROAD de Harvard y el MIT. Actualmente es Investigador en Ciencias Médicas “C”, adscrito al Laboratorio de Inmunogenómica y Enfermedades Metabólicas del INMEGEN y es miembro del Sistema Nacional de Investigadores (SNI) Nivel I.

Desde 2012 colabora en las líneas de investigación Genómica de enfermedades metabólicas, Genómica de enfermedades autoinmunes, Genómica de poblaciones y Genómica del Microbioma, englobando proyectos dirigidos a entender las bases genéticas que contribuyen a la diversificación poblacional y que predisponen al desarrollo de las enfermedades más comunes en nuestro país, entre otros temas.

Estas líneas han tenido contribuciones importantes, tales como la identificación de un incremento en el número de copias del gen TLR7 que un confiere OR elevado (3.07) para el desarrollo de Lupus Eritematoso Sistémico (LES). También derivado de las investigaciones en diabetes y como parte de los consorcios SIGMA T2D, ha contribuido a la identificación genes que confieren riesgo para DT2 en la población mexicana, estos estudios sugieren que los genes SLC16A11 y HNF1A son factores de riesgo exclusivos de las poblaciones con ancestría nativa americana.
Ha publicado 17 artículos de investigación en revistas internacionales. Muchos de los resultados de las líneas mencionados se han publicado en revistas del más alto impacto, tales como Nature, Jama, Diabetes, Annals of the Rheumatic Diseases entre otras y cuenta con cerca de 1150 citas. Ha dirigido 5 tesis, que incluyen 3 de especialidad y 2 de licenciatura. Ha recibido 2 premios y distinciones como becario del CONACyT y de la fundación Carlos Slim para la Salud. Destaca el Premio Nacional de Investigación “Fundación GSK-FUNSALUD 2014” al mejor trabajo de investigación en el área clínica.

Artículos

  • Martinez-Hernandez A, Mendoza-Caamal EC, Mendiola-Vidal NG, Barajas-Olmos F, Villafan-Bernal JR, Jimenez-Ruiz JL, Monge-Cazares T, Garcia-Ortiz H, Cubas CC, Centeno-Cruz F, Alaez-Verson C, Ortega-Torres S, Luna-Castaneda ADC, Baca V, Lezana JL, Orozco L. CFTR pathogenic variants spectrum in a cohort of Mexican patients with cystic fibrosis. Heliyon. 2024 Apr 15; 10(7):e28984.

  • Berumen J, Orozco L, Gallardo-Rincon H, Juarez-Torres E, Barrera E, Cruz-Lopez M, Benuto RE, Ramos-Martinez E, Marin-Madina M, Alvarado-Silva A, Valladares-Salgado A, Peralta-Romero JJ, Garcia-Ortiz H, Martinez-Juarez LA, Montoya A, Alvarez-Hernandez DA, Alegre-Diaz J, Kuri-Morales P, Tapia-Conyer R. Association of tyrosine hydroxylase 01 (TH01) microsatellite and insulin gene (INS) variable number of tandem repeat (VNTR) with type 2 diabetes and fasting insulin secretion in Mexican population. J Endocrinol Invest. 2024 Mar; 47(3):571-583.

  • Ziyatdinov A, Torres J, Alegre-Diaz J, Backman J, Mbatchou J, Turner M, Gaynor SM, Joseph T, Zou Y, Liu D, Wade R, Staples J, Panea R, Popov A, Bai X, Balasubramanian S, Habegger L, Lanche R, Lopez A, Maxwell E, Jones M, Garcia-Ortiz H, Ramirez-Reyes R, Santacruz-Benitez R, Nag A, Smith KR, Damask A, Lin N, Paulding C, Reppell M, Zollner S, Jorgenson E, Salerno W, Petrovski S, Overton J, Reid J, Thornton TA, Abecasis G, Berumen J, Orozco-Orozco L, Collins R, Baras A, Hill MR, Emberson JR, Marchini J, Kuri-Morales P, Tapia-Conyer R. Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City. Nature. 2024 Feb; 626(8001):E18.

  • Anaya-Morua W, Villafan-Bernal JR, Ramirez-Moreno E, Garcia-Ortiz H, Martinez-Portilla RJ, Contreras-Cubas C, Martinez-Hernandez A, Centeno-Cruz F, Pedroza-Montoya FE, Orozco L, Barajas-Olmos F. Total Antioxidant Capacity in Obese and Non-Obese Subjects and Its Association with Anthropo-Metabolic Markers: Systematic Review and Meta-Analysis. Antioxidants (Basel). 2023 Jul 28; 12(8):None.

  • Reyes-Gonzalez J, Barajas-Olmos F, Garcia-Ortiz H, Magraner-Pardo L, Pons T, Moreno S, Aguirre-Cruz L, Reyes-Abrahantes A, Martinez-Hernandez A, Contreras-Cubas C, Barrios-Payan J, Ruiz-Garcia HJ, Hernandez-Pando R, Quinones-Hinojosa A, Orozco L, Abrahantes-Perez MDC. Brain Radiotoxicity-Related 15CAcBRT Gene Expression Signature Predicts Survival Prognosis of Glioblastoma Patients. Neuro Oncol. 2023 Jul 8; 1:.

  • Berumen J, Orozco L, Gallardo-Rincon H, Rivas F, Barrera E, Benuto RE, Garcia-Ortiz H, Marin-Medina M, Juarez-Torres E, Alvarado-Silva A, Ramos-Martinez E, MartInez-Juarez LA, Lomelin-Gascon J, Montoya A, Ortega-Montiel J, Alvarez-Hernandez DA, Larriva-Shad J, Tapia-Conyer R. Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case-control study. Biol Sex Differ. 2023 Jun 8; 14(1):39.

  • Chavira-Suarez E, Hernandez-Olvera AL, Flores-Torres M, Celaya-Cruz KR, Gitler S, De la Cerda-Angeles JC, Espinosa-Maldonado NC, Flores-Jasso CF, Gutierrez H, Vadillo-Ortega F. Longitudinal large-scale changes in maternal circulating microRNAs associated with gestation-related compartments, fetal sex, and growth during and post-pregnancy. Genomics. 2023 May; 115(3):110628.

  • Baca P, Barajas-Olmos F, Mirzaeicheshmeh E, Zerrweck C, Guilbert L, Sanchez EC, Flores-Huacuja M, Villafan R, Martinez-Hernandez A, Garcia-Ortiz H, Contreras-Cubas C, Centeno-Cruz F, Orozco L. DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity. Nutr Diabetes. 2022 Dec 19; 12(1):50.

  • Salazar-Valencia IG, Villamil-Ramirez H, Barajas-Olmos F, Guevara-Cruz M, Macias-Kauffer LR, Garcia-Ortiz H, Hernandez-Vergara O, De Sandy-Galan DAD, Leon-Mimila P, Centeno-Cruz F, Gonzalez-Salazar LE, Guizar-Heredia R, Pichardo-Ontiveros E, Jacobo-Albavera L, Posadas-Sanchez R, Vargas-Alarcon G, Velazquez-Cruz R, Gutierrez-Aguilar R, Zerrweck C, Rocha-Gonzalez HI, Reyes-Garcia JG, Carrasco-Portugal MD, Flores-Murrieta FJ, Tovar AR, Orozco L, Villarreal-Molina T, Canizales-Quinteros S. Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions. Genes (Basel). 2022 DEC; 13(12):None.

  • Garcia-Ortiz H, Barajas-Olmos F, Contreras-Cubas C, Reynolds AW, Flores-Huacuja M, Snow M, Ramos-Madrigal J, Baca P, Lopez-Escobar TA, Bolnick DA, Flores-Martinez SE, Ortiz-Lopez R, Kostic AD, Villafan-Bernal JR, Galaviz-Hernandez C, Centeno-Cruz F, Garcia-Zapien AG, Monge-Cazares T, Lazalde-Ramos BP, Loeza-Becerra F, Abrahantes-Perez MD, Rangel-Villalobos H, Sosa-Macias M, Rojas-Martinez A, Martinez-Hernandez A, Orozco L. Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico. Genes (Basel). 2022 DEC; 13(12):None.

  • Askapuli A, Vilar M, Garcia-Ortiz H, Zhabagin M, Sabitov Z, Akilzhanova A, Ramanculov E, Schamiloglu U, Martinez-Hernandez A, Contreras-Cubas C, Barajas-Olmos F, Schurr TG, Zhumadilov Z, Flores-Huacuja M, Orozco L, Hawks J, Saitou N. Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia. PLoS One. 2022; 17(11):e0277771.

  • Jimenez-Morales JM, Hernandez-Cuenca YE, Reyes-Abrahantes A, Ruiz-Garcia H, Barajas-Olmos F, Garcia-Ortiz H, Orozco L, Quinones-Hinojosa A, Reyes-Gonzalez J, Del Carmen Abrahantes-Perez M. MicroRNA delivery systems in glioma therapy and perspectives: A systematic review. J Control Release. 2022 Jul 26; :.

  • Contreras-Cubas C, Barajas-Olmos F, Frayre-Martinez MI, Siordia-Reyes G, Guizar-Sanchez CC, Garcia-Ortiz H, Orozco L, Baca V. Dysferlinopathy misdiagnosed with juvenile polymyositis in the pre-symptomatic stage of hyperCKemia: a case report and literature review. BMC Med Genomics. 2022 Jun 20; 15(1):139.

  • Jurado-Camacho PA, Cid-Soto MA, Barajas-Olmos F, Garcia-Ortiz H, Baca-Peynado P, Martinez-Hernandez A, Centeno-Cruz F, Contreras-Cubas C, Gonzalez-Villalpando ME, Saldana-Alvarez Y, Salas-Martinez G, Mendoza-Caamal EC, Gonzalez-Villalpando C, Cordova EJ, Orozco L. Exome Sequencing Data Analysis and a Case-Control Study in Mexican Population Reveals Lipid Trait Associations of New and Known Genetic Variants in Dyslipidemia-Associated Loci. Front Genet. 2022; 13:807381.

  • Fernandez-Rhodes L, Graff M, Buchanan VL, Justice AE, Highland HM, Guo X, Zhu W, Chen HH, Young KL, Adhikari K, Palmer ND, Below JE, Bradfield J, Pereira AC, Glover L, Kim D, Lilly AG, Shrestha P, Thomas AG, Zhang X, Chen M, Chiang CWK, Pulit S, Horimoto A, Krieger JE, Guindo-Martinez M, Preuss M, Schumann C, Smit RAJ, Torres-Mejia G, Acuna-Alonzo V, Bedoya G, Bortolini MC, Canizales-Quinteros S, Gallo C, Gonzalez-Jose R, Poletti G, Rothhammer F, Hakonarson H, Igo R, Adler SG, Iyengar SK, Nicholas SB, Gogarten SM, Isasi CR, Papnicolaou G, Stilp AM, Qi Q, Kho M, Smith JA, Langefeld CD, Wagenknecht L, Mckean-Cowdin R, Gao XR, Nousome D, Conti DV, Feng Y, Allison MA, Arzumanyan Z, Buchanan TA, Ida Chen YD, Genter PM, Goodarzi MO, Hai Y, Hsueh W, Ipp E, Kandeel FR, Lam K, Li X, Nadler JL, Raffel LJ, Roll K, Sandow K, Tan J, Taylor KD, Xiang AH, Yao J, Audirac-Chalifour A, de Jesus Peralta Romero J, Hartwig F, Horta B, Blangero J, Curran JE, Duggirala R, Lehman DE, Puppala S, Fejerman L, John EM, Aguilar-Salinas C, Burtt NP, Florez JC, Garcia-Ortiz H, Gonzalez-Villalpando C, Mercader J, Orozco L, Tusie-Luna T, Blanco E, Gahagan S, Cox NJ, Hanis C, Butte NF, Cole SA, Comuzzie AG, Voruganti VS, Rohde R, Wang Y, Sofer T, Ziv E, Grant SFA, Ruiz-Linares A, Rotter JI, Haiman CA, Parra EJ, Cruz M, Loos RJF, North KE. Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium. HGG Adv. 2022 Apr 14; 3(2):100099.

  • Aguilar-Ordonez I, Perez-Villatoro F, Garcia-Ortiz H, Barajas-Olmos F, Ballesteros-Villascan J, Ram Gonzalez-Buenfil, Fresno C, Garciarrubio A, Fernandez-Lopez JC, Tovar H, Hernandez-Lemus E, Orozco L, Soberon X, Morett E. Correction: Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights. PLoS One. 2022; 17(5):e0269217.

  • Hindy G, Dornbos P, Chaffin MD, Liu DJ, Wang M, Selvaraj MS, Zhang D, Park J, Aguilar-Salinas CA, Antonacci-Fulton L, Ardissino D, Arnett DK, Aslibekyan S, Atzmon G, Ballantyne CM, Barajas-Olmos F, Barzilai N, Becker LC, Bielak LF, Bis JC, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Bown MJ, Brody JA, Broome JG, Burtt NP, Cade BE, Centeno-Cruz F, Chan E, Chang YC, Chen YI, Cheng CY, Choi WJ, Chowdhury R, Contreras-Cubas C, Cordova EJ, Correa A, Cupples LA, Curran JE, Danesh J, de Vries PS, DeFronzo RA, Doddapaneni H, Duggirala R, Dutcher SK, Ellinor PT, Emery LS, Florez JC, Fornage M, Freedman BI, Fuster V, Garay-Sevilla ME, Garcia-Ortiz H, Germer S, Gibbs RA, Gieger C, Glaser B, Gonzalez C, Gonzalez-Villalpando ME, Graff M, Graham SE, Grarup N, Groop LC, Guo X, Gupta N, Han S, Hanis CL, Hansen T, He J, Heard-Costa NL, Hung YJ, Hwang MY, Irvin MR, Islas-Andrade S, Jarvik GP, Kang HM, Kardia SLR, Kelly T, Kenny EE, Khan AT, Kim BJ, Kim RW, Kim YJ, Koistinen HA, Kooperberg C, Kuusisto J, Kwak SH, Laakso M, Lange LA, Lee J, Lee S, Lehman DM, Lemaitre RN, Linneberg A, Liu J, Loos RJF, Lubitz SA, Lyssenko V, Ma RCW, Martin LW, Martinez-Hernandez A, Mathias RA, McGarvey ST, McPherson R, Meigs JB, Meitinger T, Melander O, Metcalf GA, Mi X, Mohlke KL, Montasser ME, Moon JY, Moreno-Macias H, Morrison AC, Muzny DM, Nelson SC, Nilsson PM, O'Connell JR, Orho-Melander M, Orozco L, Palmer CNA, Palmer ND, Park CJ, Park KS, Pedersen O, Peralta JM, Peyser PA, Post WS, Preuss M, Psaty BM, Qi Q, Rao DC, Redline S, Reiner AP, Revilla-Monsalve C, Rich SS, Samani N, Schunkert H, Schurmann C, Seo D, Seo JS, Sim X, Sladek R, Small KS, So WY, Stilp AM, Tai ES, Tam CHT, Taylor KD, Teo YY, Thameem F, Tomlinson B, Tsai MY, Tuomi T, Tuomilehto J, Tusie-Luna T, Udler MS, van Dam RM, Vasan RS, Viaud Martinez KA, Wang FF, Wang X, Watkins H, Weeks DE, Wilson JG, Witte DR, Wong TY, Yanek LR, Kathiresan S, Rader DJ, Rotter JI, Boehnke M, McCarthy MI, Willer CJ, Natarajan P, Flannick JA, Khera AV, Peloso GM. Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes. Am J Hum Genet. 2022 Jan 6; 109(1):81-96.

  • Mirzaeicheshmeh E, Zerrweck C, Centeno-Cruz F, Baca-Peynado P, Martinez-Hernandez A, Garcia-Ortiz H, Contreras-Cubas C, Salas-Martinez MG, Saldana-Alvarez Y, Mendoza-Caamal EC, Barajas-Olmos F, Orozco L. Alterations of DNA methylation during adipogenesis differentiation of mesenchymal stem cells isolated from adipose tissue of patients with obesity is associated with type 2 diabetes. Adipocyte. 2021 Dec; 10(1):493-504.

  • Garcia-Ortiz H, Barajas-Olmos F, Contreras-Cubas C, Cid-Soto MA, Cordova EJ, Centeno-Cruz F, Mendoza-Caamal E, Ciceron-Arellano I, Flores-Huacuja M, Baca P, Bolnick DA, Snow M, Flores-Martinez SE, Ortiz-Lopez R, Reynolds AW, Blanchet A, Morales-Marin M, Velazquez-Cruz R, Kostic AD, Galaviz-Hernandez C, Garcia-Zapien AG, Jimenez-Lopez JC, Leon-Reyes G, Salas-Bautista EG, Lazalde-Ramos BP, Jimenez-Ruiz JL, Salas-Martinez G, Ramos-Madrigal J, Mirzaeicheshmeh E, Saldana-Alvarez Y, Del Carmen Abrahantes-Perez M, Loeza-Becerra F, Mojica-Espinosa R, Sanchez-Quinto F, Rangel-Villalobos H, Sosa-Macias M, Sanchez-Corona J, Rojas-Martinez A, Martinez-Hernandez A, Orozco L. The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas. Nat Commun. 2021 Oct 12; 12(1):5942.

  • Morales-Rivera MI, Alemon-Medina R, Martinez-Hernandez A, Gomez-Garduno J, Mirzaeicheshmeh E, Altamirano-Bustamante NF, Ilizaliturri-Flores I, Mendoza-Caamal EC, Perez-Guille MG, Garcia-Alvarez R, Contreras-Cubas C, Centeno-Cruz F, Revilla-Monsalve C, Garcia-Ortiz H, Barajas-Olmos F, Orozco L. The L125F MATE1 variant enriched in populations of Amerindian origin is associated with increased plasma levels of metformin and lactate. Biomed Pharmacother. 2021 Oct; 142:112009.

  • Mendoza-Caamal EC, Barajas-Olmos F, Mirzaeicheshmeh E, Ilizaliturri-Flores I, Aguilar-Salinas CA, Gomez-Velasco DV, Ciceron-Arellano I, Resendiz-Rodriguez A, Martinez-Hernandez A, Contreras-Cubas C, Islas-Andrade S, Zerrweck C, Garcia-Ortiz H, Orozco L. Two novel variants in DYRK1B causative of AOMS3: expanding the clinical spectrum. Orphanet J Rare Dis. 2021 Jun 30; 16(1):291.

  • Goodrich JK, Singer-Berk M, Son R, Sveden A, Wood J, England E, Cole JB, Weisburd B, Watts N, Caulkins L, Dornbos P, Koesterer R, Zappala Z, Zhang H, Maloney KA, Dahl A, Aguilar-Salinas CA, Atzmon G, Barajas-Olmos F, Barzilai N, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Centeno-Cruz F, Chambers JC, Chami N, Chan E, Chan J, Cheng CY, Cho YS, Contreras-Cubas C, Cordova E, Correa A, DeFronzo RA, Duggirala R, Dupuis J, Garay-Sevilla ME, Garcia-Ortiz H, Gieger C, Glaser B, Gonzalez-Villalpando C, Gonzalez ME, Grarup N, Groop L, Gross M, Haiman C, Han S, Hanis CL, Hansen T, Heard-Costa NL, Henderson BE, Hernandez JMM, Hwang MY, Islas-Andrade S, Jorgensen ME, Kang HM, Kim BJ, Kim YJ, Koistinen HA, Kooner JS, Kuusisto J, Kwak SH, Laakso M, Lange L, Lee JY, Lee J, Lehman DM, Linneberg A, Liu J, Loos RJF, Lyssenko V, Ma RCW, Martinez-Hernandez A, Meigs JB, Meitinger T, Mohlke KL, Morris AD, Morrison AC, Ng MCY, Nilsson PM, O'Donnell CJ, Orozco L, Palmer CNA, Park KS, Post WS, Pedersen O, Preuss M, Psaty BM, Reiner AP, Revilla-Monsalve C, Rich SS, Rotter JI, Saleheen D, Schurmann C, Sim X, Sladek R, Small KS, So WY, Spector TD, Strauch K, Strom TM, Tai ES, Tam CHT, Teo YY, Thameem F, Tomlinson B, Tracy RP, Tuomi T, Tuomilehto J, Tusie-Luna T, van Dam RM, Vasan RS, Wilson JG, Witte DR, Wong TY, Burtt NP, Zaitlen N, McCarthy MI, Boehnke M, Pollin TI, Flannick J, Mercader JM, O'Donnell-Luria A, Baxter S, Florez JC, MacArthur DG, Udler MS. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nat Commun. 2021 Jun 9; 12(1):3505.

  • Wibowo MC, Yang Z, Borry M, Hubner A, Huang KD, Tierney BT, Zimmerman S, Barajas-Olmos F, Contreras-Cubas C, Garcia-Ortiz H, Martinez-Hernandez A, Luber JM, Kirstahler P, Blohm T, Smiley FE, Arnold R, Ballal SA, Pamp SJ, Russ J, Maixner F, Rota-Stabelli O, Segata N, Reinhard K, Orozco L, Warinner C, Snow M, LeBlanc S, Kostic AD. Reconstruction of ancient microbial genomes from the human gut. Nature. 2021 Jun; 594(7862):234-239.

  • Aguilar-Ordonez I, Perez-Villatoro F, Garcia-Ortiz H, Barajas-Olmos F, Ballesteros-Villascan J, Gonzalez-Buenfil R, Fresno C, Garciarrubio A, Fernandez-Lopez JC, Tovar H, Hernandez-Lemus E, Orozco L, Soberon X, Morett E. Whole genome variation in 27 Mexican indigenous populations, demographic and biomedical insights. PLoS One. 2021; 16(4):e0249773.

  • Mendoza-Caamal EC, Barajas-Olmos F, Garcia-Ortiz H, Ciceron-Arellano I, Martinez-Hernandez A, Cordova EJ, Esparza-Aguilar M, Contreras-Cubas C, Centeno-Cruz F, Cid-Soto M, Morales-Marin ME, Resendiz-Rodriguez A, Jimenez-Ruiz JL, Salas-Martinez MG, Saldana-Alvarez Y, Mirzaeicheshmeh E, Rojas-Martinez MR, Orozco L. Metabolic syndrome in indigenous communities in Mexico: a descriptive and cross-sectional study. BMC Public Health. 2020 Mar 17; 20(1):339.

  • Yin W, Cerda-Hernandez N, Castillo-Morales A, Ruiz-Tejada-Segura ML, Monzon-Sandoval J, Moreno-Castilla P, Perez-Ortega R, Bermudez-Rattoni F, Urrutia AO, Gutierrez H. Transcriptional, Behavioral and Biochemical Profiling in the 3xTg-AD Mouse Model Reveals a Specific Signature of Amyloid Deposition and Functional Decline in Alzheimer's Disease. Front Neurosci. 2020; 14:602642.

  • Salas-Martinez MG, Saldana-Alvarez Y, Cordova EJ, Mendiola-Soto DK, Cid-Soto MA, Luckie-Duque A, Vicenteno-Ayala H, Barajas-Olmos F, Contreras-Cubas C, Garcia-Ortiz H, Jimenez-Ruiz JL, Centeno-Cruz F, Martinez-Hernandez A, Mendoza-Caamal EC, Mirzaeicheshmeh E, Orozco L. Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population. PLoS One. 2019; 14(12):e0225030.

  • Gonzalez-Covarrubias V, Morales-Franco M, Cruz-Correa OF, Martinez-Hernandez A, Garcia-Ortiz H, Barajas-Olmos F, Genis-Mendoza AD, Martinez-Magana JJ, Nicolini H, Orozco L, Soberon X. Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico. Front Pharmacol. 2019; 10:1169.

  • Martinez-Magana JJ, Genis-Mendoza AD, Tovilla-Zarate CA, Gonzalez-Castro TB, Juarez-Rojop IE, Hernandez-Diaz Y, Martinez-Hernandez AG, Garcia-Ortiz H, Orozco L, Lopez-Narvaez ML, Nicolini H. Association between APOE polymorphisms and lipid profile in Mexican Amerindian population. Mol Genet Genomic Med. 2019 Nov; 7(11):e958.

  • Contreras-Cubas C, Garcia-Ortiz H, Velazquez-Cruz R, Barajas-Olmos F, Baca P, Martinez-Hernandez A, Barbosa-Cobos RE, Ramirez-Bello J, Lopez-Hernandez MA, Svyryd Y, Mutchinick OM, Baca V, Orozco L. Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans. Sci Rep. 2019 Aug 21; 9(1):12165.

  • Martinez-Hernandez A, Larrosa J, Barajas-Olmos F, Garcia-Ortiz H, Mendoza-Caamal EC, Contreras-Cubas C, Mirzaeicheshmeh E, Lezana JL, Orozco L. Next-generation sequencing for identifying a novel/de novo pathogenic variant in a Mexican patient with cystic fibrosis: a case report. BMC Med Genomics. 2019 May 22; 12(1):68.

  • Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, Contreras-Cubas C, Cordova E, Correa A, Cortes M, DeFronzo RA, Dolan L, Drews KL, Elliott A, Floyd JS, Gabriel S, Garay-Sevilla ME, Garcia-Ortiz H, Gross M, Han S, Heard-Costa NL, Jackson AU, Jorgensen ME, Kang HM, Kelsey M, Kim BJ, Koistinen HA, Kuusisto J, Leader JB, Linneberg A, Liu CT, Liu J, Lyssenko V, Manning AK, Marcketta A, Malacara-Hernandez JM, Martinez-Hernandez A, Matsuo K, Mayer-Davis E, Mohlke KL, Morrison AC, Ndungu A, Ng MCY, O'Dushlaine C, Payne AJ, Pihoker C, Post WS, Preuss M, Psaty BM, Vasan RS, Rayner NW, Reiner AP, Revilla-Monsalve C, Robertson NR, Santoro N, Schurmann C, So WY, Soberon X, Stringham HM, Strom TM, Tam CHT, Thameem F, Tomlinson B, Torres JM, Tracy RP, van Dam RM, Vujkovic M, Wang S, Welch RP, Witte DR, Wong TY, Atzmon G, Barzilai N, Blangero J, Bonnycastle LL, Bowden DW, Chambers JC, Chan E, Cheng CY, Cho YS, Collins FS, de Vries PS, Duggirala R, Glaser B, Gonzalez C, Gonzalez ME, Groop L, Kooner JS, Kwak SH, Laakso M, Lehman DM, Nilsson P, Spector TD, Tai ES, Tuomi T, Tuomilehto J, Wilson JG, Aguilar-Salinas CA, Bottinger E, Burke B, Carey DJ, Chan JCN, Dupuis J, Frossard P, Heckbert SR, Hwang MY, Kim YJ, Kirchner HL, Lee JY, Lee J, Loos RJF, Ma RCW, Morris AD, O'Donnell CJ, Palmer CNA, Pankow J, Park KS, Rasheed A, Saleheen D, Sim X, Small KS, Teo YY, Haiman C, Hanis CL, Henderson BE, Orozco L, Tusie-Luna T, Dewey FE, Baras A, Gieger C, Meitinger T, Strauch K, Lange L, Grarup N, Hansen T, Pedersen O, Zeitler P, Dabelea D, Abecasis G, Bell GI, Cox NJ, Seielstad M, Sladek R, Meigs JB, Rich SS, Rotter JI, Altshuler D, Burtt NP, Scott LJ, Morris AP, Florez JC, McCarthy MI, Boehnke M. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. 2019 Jun; 570(7759):71-76.

  • Reynolds AW, Mata-Miguez J, Miro-Herrans A, Briggs-Cloud M, Sylestine A, Barajas-Olmos F, Garcia-Ortiz H, Rzhetskaya M, Orozco L, Raff JA, Hayes MG, Bolnick DA. Comparing signals of natural selection between three Indigenous North American populations. Proc Natl Acad Sci USA. 2019 Apr 15; 116:.

  • Berumen J, Orozco L, Betancourt-Cravioto M, Gallardo H, Zulueta M, Mendizabal L, Simon L, Benuto RE, Ramirez-Campos E, Marin M, Juarez E, Garcia-Ortiz H, Martinez-Hernandez A, Venegas-Vega C, Peralta-Romero J, Cruz M, Tapia-Conyer R. Influence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study. Sci Rep. 2019 Feb 26; 9(1):2748.

  • Boisson-Dupuis S, Ramirez-Alejo N, Li Z, Patin E, Rao G, Kerner G, Lim CK, Krementsov DN, Hernandez N, Ma CS, Zhang Q, Markle J, Martinez-Barricarte R, Payne K, Fisch R, Deswarte C, Halpern J, Bouaziz M, Mulwa J, Sivanesan D, Lazarov T, Naves R, Garcia P, Itan Y, Boisson B, Checchi A, Jabot-Hanin F, Cobat A, Guennoun A, Jackson CC, Pekcan S, Caliskaner Z, Inostroza J, Costa-Carvalho BT, de Albuquerque JAT, Garcia-Ortiz H, Orozco L, Ozcelik T, Abid A, Rhorfi IA, Souhi H, Amrani HN, Zegmout A, Geissmann F, Michnick SW, Muller-Fleckenstein I, Fleckenstein B, Puel A, Ciancanelli MJ, Marr N, Abolhassani H, Balcells ME, Condino-Neto A, Strickler A, Abarca K, Teuscher C, Ochs HD, Reisli I, Sayar EH, El-Baghdadi J, Bustamante J, Hammarstrom L, Tangye SG, Pellegrini S, Quintana-Murci L, Abel L, Casanova JL. Tuberculosis and impaired IL-23-dependent IFN-gamma immunity in humans homozygous for a common TYK2 missense variant. Sci Immunol. 2018 Dec 21; 3(30):.

  • Cid-Soto MA, Martinez-Hernandez A, Garcia-Ortiz H, Cordova EJ, Barajas-Olmos F, Centeno-Cruz F, Contreras-Cubas C, Mendoza-Caamal EC, Ciceron-Arellano I, Morales-Rivera MI, Jimenez-Ruiz JL, Salas-Martinez G, Saldana-Alvarez Y, Revilla-Monsalve C, Islas-Andrade S, Orozco L. Gene variants in AKT1, GCKR and SOCS3 are differentially associated with metabolic traits in Mexican Amerindians and Mestizos. Gene. 2018 Dec 30; 679:160-171.

  • Martagón AJ., Bello-Chavolla OY., Arellano-Campos O., Almeda-Valdés P., Walford GA., Cruz-Bautista I., Gómez-Velasco DV., Mehta R., Muñoz-Hernández L., Sevilla-González M., Viveros-Ruiz TL., Ordoñez-Sánchez ML., Rodríguez-Guillen R., Florez JC., Tusié-Luna MT., Aguilar-Salinas CA, Mercader JM., Huerta-Chagoya A., Moreno-Macías H., García-Ortiz H., Manning A., Caulkins L., Flannick J., Patterson N., Martínez-Hernández A., Centeno-Cruz F., Barajas-Olmos FM., Zerrweck C., Contreras-Cubas C., Mendoza-Caamal E., Revilla-Monsalve C., Islas Andrade S., Córdova E, . Soberón X., González-Villalpando ME., Wilkens L., Le Marchand L., Monroe K., Kolonel L., Rodríguez-Torres M., Segura-Kato Y., Muñoz-Hernández LL, Martagón AJ, Sevilla Gonzalez MDR, Gómez D, Almeda-Valdés P, Garay ME, Malacara Hernandez JM, Burtt NP, Cortes ML, Altshuler DM, Haiman CA, González-Villalpando C, Orozco L., Tusié-Luna T. Mexican Carriers of the HNF1A p.E508K Variant Do Not Experience an Enhanced Response to Sulfonylureas. Am J Med Genet. 2018; 41(8):.

  • Romero-Hidalgo S, Ochoa-Leyva A, Garciarrubio A, Acuna-Alonzo V, Antunez-Arguelles E, Balcazar-Quintero M, Barquera-Lozano R, Carnevale A, Cornejo-Granados F, Fernandez-Lopez JC, Garcia-Herrera R, Garcia-Ortiz H, Granados-Silvestre A, Granados J, Guerrero-Romero F, Hernandez-Lemus E, Leon-Mimila P, Macin-Perez G, Martinez-Hernandez A, Menjivar M, Morett E, Orozco L, Ortiz-Lopez G, Perez-Villatoro F, Rivera-Morales J, Riveros-McKay F, Villalobos-Comparan M, Villamil-Ramirez H, Villarreal-Molina T, Canizales-Quinteros S, Soberon X. Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing. Nat Commun. 2017 Oct 18; 8(1):1005.

  • Mercader JM, Liao RG, Bell AD, Dymek Z, Estrada K, Tukiainen T, Huerta-Chagoya A, Moreno-Macias H, Jablonski KA, Hanson RL, Walford GA, Moran I, Chen L, Agarwala V, Ordonez-Sanchez ML, Rodriguez-Guillen R, Rodriguez-Torres M, Segura-Kato Y, Garcia-Ortiz H, Centeno-Cruz F, Barajas-Olmos F, Caulkins L, Puppala S, Fontanillas P, Williams AL, Bonas-Guarch S, Hartl C, Ripke S, Tooley K, Lane J, Zerrweck C, Martinez-Hernandez A, Cordova EJ, Contreras-Cubas C, Gonzalez-Villalpando ME, Cruz-Bautista I, Munoz-Hernandez L, Gomez-Velasco D, Alvirde U, Henderson BE, Wilkens LR, Le Marchand L, Arellano-Campos O, Riba L, Harden M, Gabriel S, Abboud HE, Cortes ML, Revilla-Monsalve C, Islas-Andrade S, Soberon X, Curran JE, Jenkinson CP, DeFronzo RA, Lehman DM, Hanis CL, Bell GI, Boehnke M, Blangero J, Duggirala R, Saxena R, MacArthur D, Ferrer J, McCarroll SA, Torrents D, Knowler WC, Baier LJ, Burtt N, Gonzalez-Villalpando C, Haiman CA, Aguilar-Salinas CA, Tusie-Luna T, Flannick J, Jacobs SBR, Orozco L, Altshuler D, Florez JC. A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes. Diabetes. 2017 Nov; 66(11):2903-2914.

En curso

Terminados

  • Caracterización de variabilidad genética en población indígena mexicana (100G-MX)
  • Identificación de variantes funcionales en genes candidato asociados con el riesgo al desarrollo de síndrome metabólico en grupos indígenas y población mestiza mexicana
  • Perfil inmunogenético en pacientes diagnosticados con espectro autista de origen mexicano
  • PROYECTO DE CONTINUIDAD: ANÁLISIS DE VARIANTES GÉNICAS ASOCIADAS A DIABETES EN LA POBLACIÓN INDÍGENA MEXICANA.
  • Tamizaje inmunogenético en pacientes con Trastorno Bipolar

Ha colaborado en proyectos y/o publicaciones con:

Dra. Cecilia Contreras Cubas
Número de colaboraciones: 4
Dr. Emilio Joaquín Cordova Alarcón
Número de colaboraciones: 2
Dra. Alma Delia Genis Mendoza
Número de colaboraciones: 2
Q.F.B Maria Guadalupe Salas Martinez
Número de colaboraciones: 2

La legalidad, veracidad y la calidad de la información es estricta responsabilidad de la dependencia, entidad o empresa productiva del Estado que la proporcionó en virtud de sus atribuciones y/o facultades normativas.